KEGG   Homo sapiens (human): 5831
Entry
5831              CDS       T01001                                 
Symbol
PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR
Name
(RefSeq) pyrroline-5-carboxylate reductase 1
  KO
K00286  pyrroline-5-carboxylate reductase [EC:1.5.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
Module
hsa_M00015  Proline biosynthesis, glutamate => proline
hsa_M00972  Proline metabolism
Network
nt06033  Glycine, serine and arginine metabolism
  Element
N01618  Proline biosynthesis, Orn to Pro
Disease
H00557  Cutis laxa
H00558  Geroderma osteodysplasticum
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    5831 (PYCR1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.2  pyrroline-5-carboxylate reductase
     5831 (PYCR1)
SSDB
Motif
Pfam: P5CR_dimer F420_oxidored NAD_Gly3P_dh_N Rossmann-like ApbA PALP
Other DBs
NCBI-GeneID: 5831
NCBI-ProteinID: NP_001269209
OMIM: 179035
HGNC: 9721
Ensembl: ENSG00000183010
UniProt: P32322
Structure
Position
17:complement(81932391..81937300)
AA seq 319 aa
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV
QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH
ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL
SPSGHTKLLPRSLAPAGKD
NT seq 960 nt   +upstreamnt  +downstreamnt
atgagcgtgggcttcatcggcgctggccagctggcttttgccctggccaagggcttcaca
gcagcaggcgtcttggctgcccacaagataatggctagctccccagacatggacctggcc
acagtttctgctctcaggaagatgggggtgaagttgacaccccacaacaaggagacggtg
cagcacagtgatgtgctcttcctggctgtgaagccacacatcatccccttcatcctggat
gaaataggcgccgacattgaggacagacacattgtggtgtcctgcgcggccggcgtcacc
atcagctccattgagaagaagctgtcagcgtttcggccagcccccagggtcatccgctgc
atgaccaacactccagtcgtggtgcgggagggggccaccgtgtatgccacaggcacgcac
gcccaggtggaggacgggaggctcatggagcagctgctgagcagcgtgggcttctgcacg
gaggtggaagaggacctgattgatgccgtcacggggctcagtggcagcggccccgcctac
gcattcacagccctggatgccctggctgatgggggtgtgaagatgggacttccaaggcgc
ctggcagtccgcctcggggcccaggccctcctgggggctgccaagatgctgctgcactca
gaacagcacccaggccagctcaaggacaacgtcagctctcctggtggggccaccatccat
gccttgcatgtgctggagagtgggggcttccgctccctgctcatcaacgctgtggaggcc
tcctgcatccgcacacgggagctgcagtccatggctgaccaggagcaggtgtcaccagcc
gccatcaagaagaccatcctggacaaggtgaagctggactcccctgcagggaccgctctg
tcaccttctggccacaccaagctgctcccccgcagcctggccccagcgggcaaggattga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (22)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (52)   
   RefSeq(nuc) (20)   
   GenBank (16)   
   EMBL (16)   
3D Structure (15)   
   PDB (15)   
Protein domain (6)   
   Pfam (6)   
All databases (141)   

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