KEGG   Homo sapiens (human): 5896
Entry
5896              CDS       T01001                                 
Symbol
RAG1, RAG-1, RNF74
Name
(RefSeq) recombination activating 1
  KO
K10628  V(D)J recombination-activating protein 1 [EC:2.3.2.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa05340  Primary immunodeficiency
Network
nt06506  Double-strand break repair
  Element
N01467  V(D)J recombination
Disease
H00092  T-B-Severe combined immunodeficiency
H01244  T+B+Severe combined immunodeficiencies (SCIDs)
H02554  Omenn syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    5896 (RAG1)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    5896 (RAG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    5896 (RAG1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     5896 (RAG1)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    5896 (RAG1)
SSDB
Motif
Pfam: RAG1 RAG1_imp_bd zf-RAG1 zf-C3HC4 zf-C3HC4_2 zf-RING_6 zf-RING_2 zf-RING_10 zf-C3HC4_4 zf-RING_UBOX
Other DBs
NCBI-GeneID: 5896
NCBI-ProteinID: NP_000439
OMIM: 179615
HGNC: 9831
Ensembl: ENSG00000166349
UniProt: P15918
Position
11:36510353..36579762
AA seq 1043 aa
MAASFPPTLGLSSAPDEIQHPHIKFSEWKFKLFRVRSFEKTPEEAQKEKKDSFEGKPSLE
QSPAVLDKADGQKPVPTQPLLKAHPKFSKKFHDNEKARGKAIHQANLRHLCRICGNSFRA
DEHNRRYPVHGPVDGKTLGLLRKKEKRATSWPDLIAKVFRIDVKADVDSIHPTEFCHNCW
SIMHRKFSSAPCEVYFPRNVTMEWHPHTPSCDICNTARRGLKRKSLQPNLQLSKKLKTVL
DQARQARQHKRRAQARISSKDVMKKIANCSKIHLSTKLLAVDFPEHFVKSISCQICEHIL
ADPVETNCKHVFCRVCILRCLKVMGSYCPSCRYPCFPTDLESPVKSFLSVLNSLMVKCPA
KECNEEVSLEKYNHHISSHKESKEIFVHINKGGRPRQHLLSLTRRAQKHRLRELKLQVKA
FADKEEGGDVKSVCMTLFLLALRARNEHRQADELEAIMQGKGSGLQPAVCLAIRVNTFLS
CSQYHKMYRTVKAITGRQIFQPLHALRNAEKVLLPGYHHFEWQPPLKNVSSSTDVGIIDG
LSGLSSSVDDYPVDTIAKRFRYDSALVSALMDMEEDILEGMRSQDLDDYLNGPFTVVVKE
SCDGMGDVSEKHGSGPVVPEKAVRFSFTIMKITIAHSSQNVKVFEEAKPNSELCCKPLCL
MLADESDHETLTAILSPLIAEREAMKSSELMLELGGILRTFKFIFRGTGYDEKLVREVEG
LEASGSVYICTLCDATRLEASQNLVFHSITRSHAENLERYEVWRSNPYHESVEELRDRVK
GVSAKPFIETVPSIDALHCDIGNAAEFYKIFQLEIGEVYKNPNASKEERKRWQATLDKHL
RKKMNLKPIMRMNGNFARKLMTKETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSC
PAKECPESLCQYSFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWA
SEGNESGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNALKTSGFTMN
PQASLGDPLGIEDSLESQDSMEF
NT seq 3132 nt   +upstreamnt  +downstreamnt
atggcagcctctttcccacccaccttgggactcagttctgccccagatgaaattcagcac
ccacatattaaattttcagaatggaaatttaagctgttccgggtgagatcctttgaaaag
acacctgaagaagctcaaaaggaaaagaaggattcctttgaggggaaaccctctctggag
caatctccagcagtcctggacaaggctgatggtcagaagccagtcccaactcagccattg
ttaaaagcccaccctaagttttcaaagaaatttcacgacaacgagaaagcaagaggcaaa
gcgatccatcaagccaaccttcgacatctctgccgcatctgtgggaattcttttagagct
gatgagcacaacaggagatatccagtccatggtcctgtggatggtaaaaccctaggcctt
ttacgaaagaaggaaaagagagctacttcctggccggacctcattgccaaggttttccgg
atcgatgtgaaggcagatgttgactcgatccaccccactgagttctgccataactgctgg
agcatcatgcacaggaagtttagcagtgccccatgtgaggtttacttcccgaggaacgtg
accatggagtggcacccccacacaccatcctgtgacatctgcaacactgcccgtcgggga
ctcaagaggaagagtcttcagccaaacttgcagctcagcaaaaaactcaaaactgtgctt
gaccaagcaagacaagcccgtcagcacaagagaagagctcaggcaaggatcagcagcaag
gatgtcatgaagaagatcgccaactgcagtaagatacatcttagtaccaagctccttgca
gtggacttcccagagcactttgtgaaatccatctcctgccagatctgtgaacacattctg
gctgaccctgtggagaccaactgtaagcatgtcttttgccgggtctgcattctcagatgc
ctcaaagtcatgggcagctattgtccctcttgccgatatccatgcttccctactgacctg
gagagtccagtgaagtcctttctgagcgtcttgaattccctgatggtgaaatgtccagca
aaagagtgcaatgaggaggtcagtttggaaaaatataatcaccacatctcaagtcacaag
gaatcaaaagagatttttgtgcacattaataaagggggccggccccgccaacatcttctg
tcgctgactcggagagctcagaagcaccggctgagggagctcaagctgcaagtcaaagcc
tttgctgacaaagaagaaggtggagatgtgaagtccgtgtgcatgaccttgttcctgctg
gctctgagggcgaggaatgagcacaggcaagctgatgagctggaggccatcatgcaggga
aagggctctggcctgcagccagctgtttgcttggccatccgtgtcaacaccttcctcagc
tgcagtcagtaccacaagatgtacaggactgtgaaagccatcacagggagacagattttt
cagcctttgcatgcccttcggaatgctgagaaggtacttctgccaggctaccaccacttt
gagtggcagccacctctgaagaatgtgtcttccagcactgatgttggcattattgatggg
ctgtctggactatcatcctctgtggatgattacccagtggacaccattgcaaagaggttc
cgctatgattcagctttggtgtctgctttgatggacatggaagaagacatcttggaaggc
atgagatcccaagaccttgatgattacctgaatggccccttcactgtggtggtgaaggag
tcttgtgatggaatgggagacgtgagtgagaagcatgggagtgggcctgtagttccagaa
aaggcagtccgtttttcattcacaatcatgaaaattactattgcccacagctctcagaat
gtgaaagtatttgaagaagccaaacctaactctgaactgtgttgcaagccattgtgcctt
atgctggcagatgagtctgaccacgagacgctgactgccatcctgagtcctctcattgct
gagagggaggccatgaagagcagtgaattaatgcttgagctgggaggcattctccggact
ttcaagttcatcttcaggggcaccggctatgatgaaaaacttgtgcgggaagtggaaggc
ctcgaggcttctggctcagtctacatttgtactctttgtgatgccacccgtctggaagcc
tctcaaaatcttgtcttccactctataaccagaagccatgctgagaacctggaacgttat
gaggtctggcgttccaacccttaccatgagtctgtggaagaactgcgggatcgggtgaaa
ggggtctcagctaaacctttcattgagacagtcccttccatagatgcactccactgtgac
attggcaatgcagctgagttctacaagatcttccagctagagataggggaagtgtataag
aatcccaatgcttccaaagaggaaaggaaaaggtggcaggccacactggacaagcatctc
cggaagaagatgaacctcaaaccaatcatgaggatgaatggcaactttgccaggaagctc
atgaccaaagagactgtggatgcagtttgtgagttaattccttccgaggagaggcacgag
gctctgagggagctgatggatctttacctgaagatgaaaccagtatggcgatcatcatgc
cctgctaaagagtgcccagaatccctctgccagtacagtttcaattcacagcgttttgct
gagctcctttctacgaagttcaagtataggtatgagggaaaaatcaccaattattttcac
aaaaccctggcccatgttcctgaaattattgagagggatggctccattggggcatgggca
agtgagggaaatgagtctggtaacaaactgtttaggcgcttccggaaaatgaatgccagg
cagtccaaatgctatgagatggaagatgtcctgaaacaccactggttgtacacctccaaa
tacctccagaagtttatgaatgctcataatgcattaaaaacctctgggtttaccatgaac
cctcaggcaagcttaggggacccattaggcatagaggactctctggaaagccaagattca
atggaattttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (8)   
   KEGG DISEASE (3)   
   OMIM (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (13)   
   RefSeq(nuc) (7)   
   GenBank (3)   
   EMBL (3)   
Protein domain (10)   
   Pfam (10)   
All databases (65)   

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