KEGG   Homo sapiens (human): 5927
Entry
5927              CDS       T01001                                 
Symbol
KDM5A, RBBP-2, RBBP2, RBP2, JARID1A
Name
(RefSeq) lysine demethylase 5A
  KO
K11446  [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5927 (KDM5A)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    5927 (KDM5A)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.67  [histone H3]-trimethyl-L-lysine4 demethylase
     5927 (KDM5A)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     5927 (KDM5A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    5927 (KDM5A)
SSDB
Motif
Pfam: PLU-1 JmjC KDM5_C-hel PHD ARID zf-C5HC2 JmjN PHD_5 PHD_2 ASH2L-like_WH
Other DBs
NCBI-GeneID: 5927
NCBI-ProteinID: NP_001036068
OMIM: 180202
HGNC: 9886
Ensembl: ENSG00000073614
UniProt: P29375
Structure
Position
12:complement(280057..389320)
AA seq 1690 aa
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDL
FRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVI
SQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAK
VCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYL
EQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDI
GVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEA
MHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKG
SSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRA
RQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSA
FNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIP
IKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPG
AKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVKGKD
SSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEE
RKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCK
DKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPGPAPPPSFIMSYK
LPMEDLKETS
NT seq 5073 nt   +upstreamnt  +downstreamnt
atggcgggcgtggggccggggggctacgcggcggagttcgtgccaccgccagagtgcccc
gtctttgagccgagttgggaggagttcacagatccgctcagctttatcggccgcatccgg
cctttggcggagaaaaccggcatctgcaaaattcggccgcccaaggactggcagcctcca
tttgcctgtgaagtaaaaagctttcgtttcactccaagagtccagcgcctgaatgaactt
gaggcaatgaccagagtgagattggatttcttggatcaactagcaaaattttgggaactt
caaggatctactctgaagatccctgtggtagagagaaaaatcctggatctgtatgctttg
agcaagattgttgccagcaaaggaggttttgaaatggtcaccaaagagaagaaatggtct
aaagtgggtagtcgcttgggatatctgccaggaaaaggaactgggtctcttttgaagtca
cattatgaaagaattctctacccatatgagcttttccagtctggtgtgagccttatgggt
gtgcagatgcctaatttagatcttaaagaaaaagtggagcctgaggttctcagcactgat
acccaaacttccccagagccaggcacaaggatgaacattctgccgaagagaacaagacgt
gtgaagactcagtcagaatctggagatgtgagtagaaacacggaactgaagaaacttcag
atttttggggctgggcccaaggttgtgggcttggcaatgggaacaaaagataaagaagat
gaggtcacccgaagacgaaaagttaccaacaggtcagacgcatttaacatgcaaatgaga
caacggaaaggcactctctctgttaactttgttgatctctatgtttgtatgttttgtggt
cggggaaacaatgaagataaattgcttttgtgtgatggatgtgatgacagctatcataca
ttttgtctaattcctccactacctgatgtgcccaaaggagactggaggtgtcctaaatgt
gtcgccgaggaatgtagcaaacctcgagaagcctttggatttgaacaagctgtacgagag
tatacacttcagagctttggagagatggcagataattttaagtctgattattttaatatg
ccagtccatatggttcccacagaactagtagaaaaggaattttggcggctggtaagcagc
attgaagaagatgttattgtggaatatggagcagatatctcctcaaaagactttggaagt
ggatttccggtgaaggatgggcggagaaagattctgccagaagaagaggaatatgcactt
tctggttggaatttgaataacatgcctgtcctggaacagtctgttcttgcacatattaat
gtggacatctctggtatgaaagtgccgtggctctatgtgggaatgtgcttctcttctttt
tgctggcacattgaggatcactggagttattccatcaactacttgcactggggggagcca
aagacatggtatggtgtgccatctcatgctgcagagcaactggaggaggtgatgagagag
ctggcccccgagttatttgaatcccagcctgatcttctgcatcagttagttaccatcatg
aaccccaacgtgctaatggagcatggtgtgcctgtgtacaggaccaatcagtgtgctggc
gagtttgttgtgacatttcctcgtgcctatcactctggatttaaccagggctacaacttt
gctgaagctgtgaacttctgtactgctgactggttgcccattggacgtcaatgtgtaaat
cattaccgacgcctaaggcgccactgtgtcttttcacacgaggaactaattttcaagatg
gcagcagatccagaatgcttagatgtggggctggctgccatggtctgcaaagaattgact
ctcatgactgaagaagaaacacgattaagagagtctgttgtacagatgggtgtcctgatg
tcagaagaagaagtgtttgaacttgttcctgatgatgagcggcagtgttcagcatgcaga
accacatgttttctctctgctctcacatgttcctgtaatcctgagcggcttgtatgtctc
taccatccaactgatctgtgcccctgccccatgcagaagaaatgtcttagatatcgctac
ccattagaagacctcccttctctgctatatggtgtaaaagtcagggcacagtcctatgac
acttgggtcagtcgtgttacagaagcattgtctgctaacttcaaccacaaaaaagatttg
attgaattgcgagtaatgctggaagatgctgaggataggaaatacccagagaatgatctc
tttcgaaaactcagggatgctgtaaaagaagctgagacctgtgcttctgtggctcagctg
cttctgagcaaaaagcagaaacacagacagagcccagatagtgggaggactcggaccaaa
ctgacagtggaagaattgaaggcctttgtccaacaactttttagtcttccgtgtgtcatc
agccaagctcggcaagtaaagaatctgctagatgatgtggaagagtttcatgaacgtgct
caggaggccatgatggatgaaaccccagattcttccaaactccagatgttgatagatatg
ggctctagtctctatgtggaactccctgaattaccacgactgaagcaagagctacaacag
gctcggtggttggacgaagtaagactgaccttatcagatccgcaacaagtcactttggat
gtcatgaagaagctgatagactctggggtagggttggcaccccaccatgctgtggagaaa
gcaatggctgaactacaggagctccttacagtctctgaacgatgggaagaaaaggctaag
gtctgcctacaggcaagaccgaggcacagtgtggcaagtttagaaagcattgtgaatgaa
gccaagaacattccagcctttctacccaatgtgttgtccttgaaagaagccttacaaaag
gctcgagaatggaccgctaaagtggaagctattcagagtggcagcaattacgcttatttg
gagcagcttgagagcttgtctgcgaaaggacgccctattcctgtgcgtcttgaagcactg
ccgcaagtggaatcacaggtagcagcagcacgggcatggagagaacggactgggcggacg
tttcttaagaagaattctagccatacattgttacaggtgctgagcccccggaccgacatt
ggtgtatatgggagtggcaaaaataggaggaaaaaagtaaaagaactaatagaaaaagaa
aaagaaaaggatctggacctggagcctctgagtgatctggaggaaggattggaggaaacc
agagatacagccatggtggtggcagttttcaaagaacgggagcaaaaagagattgaagcc
atgcattctctcagagcagccaacctagccaagatgacaatggtggaccgcatagaagaa
gtaaaattttgcatttgccgcaagacagccagtgggtttatgctacagtgtgagctctgc
aaagactggttccataacagctgtgttcctcttcctaaatcaagttcccaaaaaaaagga
tccagctggcaagctaaagaagtaaaattcctttgccctctttgtatgcggtctcgaagg
cccaggctagagactattctgtcactcctggtatcccttcagaagttgcccgtacggttg
cctgaaggagaggccctgcagtgtttgacagaacgtgctatgagttggcaagatagagcg
cggcaggctctagccacagatgaactatcctctgccctggccaaactatctgtgttgagc
cagcgtatggtggaacaggcggctcgagaaaaaactgaaaagatcatcagtgcagaactc
caaaaagcagctgccaatccagacttacagggacacttacctagtttccagcagtctgct
tttaaccgggtggtgagcagtgtgtcatcttctcctcgacaaacaatggactatgatgat
gaagaaacagactctgatgaagacattcgagagacatatggctacgacatgaaggacaca
gccagtgtgaagtcctctagtagtcttgaacccaatcttttttgtgatgaagagattccc
atcaaatccgaggaggtggtgacccacatgtggacagcaccttcattttgtgcagagcat
gcttattcttctgcttctaagagttgttctcaaggttctagcaccccaaggaaacaacct
cggaagagccctttggtgccccgaagtttggaacctccagtgctggagttgtcacctgga
gctaaggcacaactggaagaacttatgatggttggagatctcctggaagtatctctggac
gagactcaacacatatggcggattttgcaggccacacacccaccctctgaagacagattc
ttgcatatcatggaggatgacagcatggaagagaaaccactaaaagtgaaaggaaaggac
tcttcagagaagaaacggaaacggaagctagaaaaggtagagcaactttttggagaagga
aaacagaagtccaaggagttaaagaaaatggacaaacctagaaagaagaaattaaaatta
ggtgcagacaaatcaaaggagctgaataaactggccaagaaactagcaaaagaagaagag
agaaagaaaaagaaggagaaggctgctgcagccaaagttgaacttgtgaaagagagcact
gaaaagaaaagagagaaaaaggtgctggacatcccctcaaagtatgactggtcaggagca
gaggagtctgatgatgagaatgctgtgtgcgcagcacagaactgccaaaggccctgcaag
gacaaggtagactgggtacaatgtgatggtggctgtgatgagtggtttcatcaagtttgt
gtgggtgtatctccagaaatggctgaaaatgaagattacatctgtataaactgtgcaaag
aagcaggggccagttagcccaggtccagcaccacctccttccttcataatgagctacaaa
ctaccaatggaggatcttaaagagaccagttag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (26)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (38)   
   RefSeq(nuc) (2)   
   GenBank (18)   
   EMBL (18)   
3D Structure (46)   
   PDB (46)   
Protein domain (10)   
   Pfam (10)   
All databases (138)   

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