KEGG   Homo sapiens (human): 5970
Entry
5970              CDS       T01001                                 
Symbol
RELA, AIF3BL3, CMCU, NFKB3, p65
Name
(RefSeq) RELA proto-oncogene, NF-kB subunit
  KO
K04735  transcription factor p65
Organism
hsa  Homo sapiens (human)
Pathway
hsa01523  Antifolate resistance
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04064  NF-kappa B signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04137  Mitophagy - animal
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04218  Cellular senescence
hsa04380  Osteoclast differentiation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04917  Prolactin signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04926  Relaxin signaling pathway
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04936  Alcoholic liver disease
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05134  Legionellosis
hsa05135  Yersinia infection
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05212  Pancreatic cancer
hsa05215  Prostate cancer
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05321  Inflammatory bowel disease
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06214  PI3K signaling (cancer)
nt06223  TNF signaling (cancer)
nt06240  Transcription (cancer)
nt06263  Hepatocellular carcinoma
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06516  TNF signaling
nt06517  TLR signaling
nt06519  RLR signaling
nt06521  NLR signaling
  Element
N00140  FUS-DDIT3 fusion to NFKB-mediated transcription
N00151  TNF-NFKB signaling pathway
N00171  KSHV vFLIP to NFKB signaling pathway
N00173  KSHV K15 to TNF-NFKB signaling pathway
N00174  KSHV vFLIP to TNF-NFKB signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00265  EBV LMP1 to NFKB signaling pathway
N00269  HCV core to TNF-NFKB signaling pathway
N00389  HCMV IE1-72 to transcription
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00398  HCMV IE2-86 to TNF-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00435  TLR1/2/4-NFKB signaling pathway
N00436  HIV Tat to TLR2/4-NFKB signaling pathway
N00437  HIV Vpu to TLR2/4-NFKB signaling pathway
N00441  HIV gp120 to TNF-NFKB signaling pathway
N00442  HIV Nef to TNF-NFKB signaling pathway
N00443  HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00504  HTLV-1 Tax to NFKB signaling pathway
N00550  HBV HBeAg to TLR2/4-NFKB signaling pathway
N00559  LIGHT-HVEM-NFKB signaling pathway
N00560  HSV gD to HVEM-NFKB signaling pathway
N00563  TLR3-NFKB signaling pathway
N00688  RIG-I-NFKB signaling pathway
N00689  MV V/P/C to RIG-I-NFKB signaling pathway
N00730  IAV NS1 to RIG-I-like receptor signaling pathway
N00929  Escherichia NleC to TNF-NFKB signaling pathway
N00932  Escherichia NleH1 to TNF-NFKB signaling pathway
N00940  NOD-NFKB signaling pathway
N00943  Shigella IpaH4.5 to TNF-NFKB signaling pathway
N00994  AGE-RAGE signaling pathway
N00996  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01112  Salmonella SopE/E2 to NOD-NFKB signaling pathway
N01118  Salmonella SpvD to TNF-NFKB signaling pathway
N01122  Salmonella PipA/GogA/GtgA to TNF-NFKB signaling pathway
N01306  AngII-AT1R-NOX2 signaling pathway
N01307  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01410  Metals to NFKB signaling pathway
N01411  Metals to NFKB signaling pathway
N01566  TLR5-NFKB signaling pathway
Disease
H02593  Chronic mucocutaneous ulceration
Drug target
Edasalonexent: D12181
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5970 (RELA)
   04014 Ras signaling pathway
    5970 (RELA)
   04064 NF-kappa B signaling pathway
    5970 (RELA)
   04668 TNF signaling pathway
    5970 (RELA)
   04066 HIF-1 signaling pathway
    5970 (RELA)
   04071 Sphingolipid signaling pathway
    5970 (RELA)
   04024 cAMP signaling pathway
    5970 (RELA)
   04151 PI3K-Akt signaling pathway
    5970 (RELA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    5970 (RELA)
  09143 Cell growth and death
   04210 Apoptosis
    5970 (RELA)
   04218 Cellular senescence
    5970 (RELA)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    5970 (RELA)
   04620 Toll-like receptor signaling pathway
    5970 (RELA)
   04621 NOD-like receptor signaling pathway
    5970 (RELA)
   04622 RIG-I-like receptor signaling pathway
    5970 (RELA)
   04623 Cytosolic DNA-sensing pathway
    5970 (RELA)
   04625 C-type lectin receptor signaling pathway
    5970 (RELA)
   04660 T cell receptor signaling pathway
    5970 (RELA)
   04658 Th1 and Th2 cell differentiation
    5970 (RELA)
   04659 Th17 cell differentiation
    5970 (RELA)
   04657 IL-17 signaling pathway
    5970 (RELA)
   04662 B cell receptor signaling pathway
    5970 (RELA)
   04062 Chemokine signaling pathway
    5970 (RELA)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    5970 (RELA)
   04917 Prolactin signaling pathway
    5970 (RELA)
   04926 Relaxin signaling pathway
    5970 (RELA)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    5970 (RELA)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    5970 (RELA)
  09149 Aging
   04211 Longevity regulating pathway
    5970 (RELA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5970 (RELA)
   05202 Transcriptional misregulation in cancer
    5970 (RELA)
   05207 Chemical carcinogenesis - receptor activation
    5970 (RELA)
   05208 Chemical carcinogenesis - reactive oxygen species
    5970 (RELA)
   05203 Viral carcinogenesis
    5970 (RELA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5970 (RELA)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    5970 (RELA)
   05221 Acute myeloid leukemia
    5970 (RELA)
   05220 Chronic myeloid leukemia
    5970 (RELA)
   05215 Prostate cancer
    5970 (RELA)
   05222 Small cell lung cancer
    5970 (RELA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    5970 (RELA)
   05170 Human immunodeficiency virus 1 infection
    5970 (RELA)
   05161 Hepatitis B
    5970 (RELA)
   05160 Hepatitis C
    5970 (RELA)
   05171 Coronavirus disease - COVID-19
    5970 (RELA)
   05164 Influenza A
    5970 (RELA)
   05162 Measles
    5970 (RELA)
   05168 Herpes simplex virus 1 infection
    5970 (RELA)
   05163 Human cytomegalovirus infection
    5970 (RELA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5970 (RELA)
   05169 Epstein-Barr virus infection
    5970 (RELA)
   05165 Human papillomavirus infection
    5970 (RELA)
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    5970 (RELA)
   05130 Pathogenic Escherichia coli infection
    5970 (RELA)
   05132 Salmonella infection
    5970 (RELA)
   05131 Shigellosis
    5970 (RELA)
   05135 Yersinia infection
    5970 (RELA)
   05133 Pertussis
    5970 (RELA)
   05134 Legionellosis
    5970 (RELA)
   05152 Tuberculosis
    5970 (RELA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    5970 (RELA)
   05145 Toxoplasmosis
    5970 (RELA)
   05140 Leishmaniasis
    5970 (RELA)
   05142 Chagas disease
    5970 (RELA)
  09163 Immune disease
   05321 Inflammatory bowel disease
    5970 (RELA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5970 (RELA)
   05022 Pathways of neurodegeneration - multiple diseases
    5970 (RELA)
  09165 Substance dependence
   05030 Cocaine addiction
    5970 (RELA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5970 (RELA)
   05418 Fluid shear stress and atherosclerosis
    5970 (RELA)
   05415 Diabetic cardiomyopathy
    5970 (RELA)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    5970 (RELA)
   04932 Non-alcoholic fatty liver disease
    5970 (RELA)
   04931 Insulin resistance
    5970 (RELA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    5970 (RELA)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    5970 (RELA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5970 (RELA)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    5970 (RELA)
SSDB
Motif
Pfam: RHD_DNA_bind RHD_dimer
Other DBs
NCBI-GeneID: 5970
NCBI-ProteinID: NP_068810
OMIM: 164014
HGNC: 9955
Ensembl: ENSG00000173039
UniProt: Q04206
Structure
Position
11:complement(65653601..65663857)
AA seq 551 aa
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
NT seq 1656 nt   +upstreamnt  +downstreamnt
atggacgaactgttccccctcatcttcccggcagagccagcccaggcctctggcccctat
gtggagatcattgagcagcccaagcagcggggcatgcgcttccgctacaagtgcgagggg
cgctccgcgggcagcatcccaggcgagaggagcacagataccaccaagacccaccccacc
atcaagatcaatggctacacaggaccagggacagtgcgcatctccctggtcaccaaggac
cctcctcaccggcctcacccccacgagcttgtaggaaaggactgccgggatggcttctat
gaggctgagctctgcccggaccgctgcatccacagtttccagaacctgggaatccagtgt
gtgaagaagcgggacctggagcaggctatcagtcagcgcatccagaccaacaacaacccc
ttccaagttcctatagaagagcagcgtggggactacgacctgaatgctgtgcggctctgc
ttccaggtgacagtgcgggacccatcaggcaggcccctccgcctgccgcctgtcctttct
catcccatctttgacaatcgtgcccccaacactgccgagctcaagatctgccgagtgaac
cgaaactctggcagctgcctcggtggggatgagatcttcctactgtgtgacaaggtgcag
aaagaggacattgaggtgtatttcacgggaccaggctgggaggcccgaggctccttttcg
caagctgatgtgcaccgacaagtggccattgtgttccggacccctccctacgcagacccc
agcctgcaggctcctgtgcgtgtctccatgcagctgcggcggccttccgaccgggagctc
agtgagcccatggaattccagtacctgccagatacagacgatcgtcaccggattgaggag
aaacgtaaaaggacatatgagaccttcaagagcatcatgaagaagagtcctttcagcgga
cccaccgacccccggcctccacctcgacgcattgctgtgccttcccgcagctcagcttct
gtccccaagccagcaccccagccctatccctttacgtcatccctgagcaccatcaactat
gatgagtttcccaccatggtgtttccttctgggcagatcagccaggcctcggccttggcc
ccggcccctccccaagtcctgccccaggctccagcccctgcccctgctccagccatggta
tcagctctggcccaggccccagcccctgtcccagtcctagccccaggccctcctcaggct
gtggccccacctgcccccaagcccacccaggctggggaaggaacgctgtcagaggccctg
ctgcagctgcagtttgatgatgaagacctgggggccttgcttggcaacagcacagaccca
gctgtgttcacagacctggcatccgtcgacaactccgagtttcagcagctgctgaaccag
ggcatacctgtggccccccacacaactgagcccatgctgatggagtaccctgaggctata
actcgcctagtgacaggggcccagaggccccccgacccagctcctgctccactgggggcc
ccggggctccccaatggcctcctttcaggagatgaagacttctcctccattgcggacatg
gacttctcagccctgctgagtcagatcagctcctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (76)   
   KEGG PATHWAY (76)   
Network (66)   
   KEGG NETWORK (66)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (45)   
   RefSeq(nuc) (13)   
   GenBank (16)   
   EMBL (16)   
3D Structure (88)   
   PDB (88)   
Protein domain (2)   
   Pfam (2)   
All databases (324)   

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