KEGG   Homo sapiens (human): 6045
Entry
6045              CDS       T01001                                 
Symbol
RNF2, BAP-1, BAP1, DING, HIPI3, LUSYAM, RING1B, RING2
Name
(RefSeq) ring finger protein 2
  KO
K10695  E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01585  Deubiquitination of H2AK119
N01586  Activation of PRC2.2 by ubiquitination of H2AK119
N01614  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes
N01620  Blocking ubiquitination of H2AK119 by CK2
N01701  Transcriptional activation by acetylation of H3K27
Disease
H02587  Luo-Schoch-Yamamoto syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    6045 (RNF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6045 (RNF2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    6045 (RNF2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     6045 (RNF2)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    6045 (RNF2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Canonical PRC1 (PRC1.2/1.4)
     6045 (RNF2)
    Noncanonical PRC1 (PRC1.1)
     6045 (RNF2)
    Noncanonical PRC1 (PRC1.3/1.5)
     6045 (RNF2)
    Noncanonical PRC1 (PRC1.6)
     6045 (RNF2)
SSDB
Motif
Pfam: RAWUL zf-C3HC4_2 zf-C3HC4 zf-RING_2 zf-C3HC4_3 zf-RING_UBOX zf-C3HC4_4 zf-Nse zf-RING_5 zf-RING_4 zf-rbx1 zf-RING_6 zf-UDP TRAF3_RING zf-C3HC4_5 zf-ANAPC11
Other DBs
NCBI-GeneID: 6045
NCBI-ProteinID: NP_009143
OMIM: 608985
HGNC: 10061
Ensembl: ENSG00000121481
UniProt: Q99496
Structure
Position
1:185045558..185102603
AA seq 336 aa
MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKN
TMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEY
EAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCS
NASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAMAIDPVMDGASEIELVFRPHPTLMEKD
DSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASG
QFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
NT seq 1011 nt   +upstreamnt  +downstreamnt
atgtctcaggctgtgcagacaaacggaactcaaccattaagcaaaacatgggaactcagt
ttatatgagttacaacgaacacctcaggaggcaataacagatggcttagaaattgtggtt
tcacctcgaagtctacacagtgaattaatgtgcccaatttgtttggatatgttgaagaac
accatgactacaaaggagtgtttacatcgtttttgtgcagactgcatcatcacagccctt
agaagtggcaacaaagaatgtcctacctgtcggaaaaaactagtttccaaaagatcacta
aggccagacccaaactttgatgcactcatcagcaaaatttatccaagtcgtgatgagtat
gaagctcatcaagagagagtattagccaggatcaacaagcacaataatcagcaagcactc
agtcacagcattgaggaaggactgaagatacaggccatgaacagactgcagcgaggcaag
aaacaacagattgaaaatggtagtggagcagaagataatggtgacagttcacactgcagt
aatgcatccacacatagcaatcaggaagcaggccctagtaacaaacggaccaaaacatct
gatgattctgggctagagcttgataataacaatgcagcaatggcaattgatccagtaatg
gatggtgctagtgaaattgaattagtattcaggcctcatcccacacttatggaaaaagat
gacagtgcacagacgagatacataaagacttctggtaacgccactgttgatcacttatcc
aagtatctggctgtgaggttagctttagaagaacttcgaagcaaaggtgaatcaaaccag
atgaaccttgatacagccagtgagaagcagtataccatttatatagcaacagccagtggc
cagttcactgtattaaatggctctttttctttggaattggtcagtgagaaatactggaaa
gtgaacaaacccatggaactttattacgcacctacaaaggagcacaaatga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (7)   
   KEGG NETWORK (7)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (25)   
   RefSeq(nuc) (7)   
   GenBank (9)   
   EMBL (9)   
3D Structure (11)   
   PDB (11)   
Protein domain (16)   
   Pfam (16)   
All databases (94)   

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