KEGG   Homo sapiens (human): 60676
Entry
60676             CDS       T01001                                 
Symbol
PAPPA2, PAPP-A2, PAPP-E, PAPPE, PLAC3, SSDA
Name
(RefSeq) pappalysin 2
  KO
K08647  pappalysin-2 [EC:3.4.24.-]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    60676 (PAPPA2)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M43: cytophagalysin family
   60676 (PAPPA2)
SSDB
Motif
Pfam: Laminin_G_3 Sushi Peptidase_M43 DUF4215 Notch Laminin_G_2 Laminin_G_1 Reprolysin_3 DUF4953 Peptidase_M10
Other DBs
NCBI-GeneID: 60676
NCBI-ProteinID: NP_064714
OMIM: 619485
HGNC: 14615
Ensembl: ENSG00000116183
UniProt: Q9BXP8
Structure
Position
1:176463175..176845601
AA seq 1791 aa
MMCLKILRISLAILAGWALCSANSELGWTRKKSLVEREHLNQVLLEGERCWLGAKVRRPR
ASPQHHLFGVYPSRAGNYLRPYPVGEQEIHHTGRSKPDTEGNAVSLVPPDLTENPAGLRG
AVEEPAAPWVGDSPIGQSELLGDDDAYLGNQRSKESLGEAGIQKGSAMAATTTTAIFTTL
NEPKPETQRRGWAKSRQRRQVWKRRAEDGQGDSGISSHFQPWPKHSLKHRVKKSPPEESN
QNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQN
NPAIIAGVFDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQ
PGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLLGGDSSEDGHYFR
GHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEV
LQGFEPEPEILSPLQPPLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNP
IVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPEC
EHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPD
SPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPA
YYGMPGHTDTMIHEVGHVLGLYHVFKGVSERESCNDPCKETVPSMETGDLCADTAPTPKS
ELCREPEPTSDTCGFTRFPGAPFTNYMSYTDDNCTDNFTPNQVARMHCYLDLVYQQWTES
RKPTPIPIPPMVIGQTNKSLTIHWLPPISGVVYDRASGSLCGACTEDGTFRQYVHTASSR
RVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHP
VQADTLTLWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKVSGV
KVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPVVVTHSHRKFTDVE
VTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGDGKVSERLGEECDDGDLVSGDGCS
KVCELEEGFNCVGEPSLCYMYEGDGICEPFERKTSIVDCGIYTPKGYLDQWATRAYSSHE
DKKKCPVSLVTGEPHSLICTSYHPDLPNHRPLTGWFPCVASENETQDDRSEQPEGSLKKE
DEVWLKVCFNRPGEARAIFIFLTTDGLVPGEHQQPTVTLYLTDVRGSNHSLGTYGLSCQH
NPLIINVTHHQNVLFHHTTSVLLNFSSPRVGISAVALRTSSRIGLSAPSNCISEDEGQNH
QGQSCIHRPCGKQDSCPSLLLDHADVVNCTSIGPGLMKCAITCQRGFALQASSGQYIRPM
QKEILLTCSSGHWDQNVSCLPVDCGVPDPSLVNYANFSCSEGTKFLKRCSISCVPPAKLQ
GLSPWLTCLEDGLWSLPEVYCKLECDAPPIILNANLLLPHCLQDNHDVGTICKYECKPGY
YVAESAEGKVRNKLLKIQCLEGGIWEQGSCIPVVCEPPPPVFEGMYECTNGFSLDSQCVL
NCNQEREKLPILCTKEGLWTQEFKLCENLQGECPPPPSELNSVEYKCEQGYGIGAVCSPL
CVIPPSDPVMLPENITADTLEHWMEPVKVQSIVCTGRRQWHPDPVLVHCIQSCEPFQADG
WCDTINNRAYCHYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPKAEENQ
NT seq 5376 nt   +upstreamnt  +downstreamnt
atgatgtgcttaaagatcctaagaataagcctggcgattttggctgggtgggcactctgt
tctgccaactctgagctgggctggacacgcaagaaatccttggttgagagggaacacctg
aatcaggtgctgttggaaggagaacgttgttggctgggggccaaggttcgaagacccaga
gcttctccacagcatcacctctttggagtctaccccagcagggctgggaactacctaagg
ccctaccccgtgggggagcaagaaatccatcatacaggacgcagcaaaccagacactgaa
ggaaatgctgtgagccttgttcccccagacctgactgaaaatccagcaggactgaggggt
gcagttgaagagccggctgccccatgggtaggggatagtcctattgggcaatctgagctg
ctgggagatgatgacgcttatctcggcaatcaaagatccaaggagtctctaggtgaggcc
gggattcagaaaggctcagccatggctgccactactaccaccgccattttcacaaccctg
aacgaacccaaaccagagacccaaaggaggggctgggccaagtccaggcagcgtcgccaa
gtgtggaagaggcgggcggaagatgggcagggagactccggtatctcttcacatttccaa
ccttggcccaagcattcccttaaacacagggtcaaaaagagtccaccggaggaaagcaac
caaaatggtggagagggctcctaccgagaagcagagacctttaactcccaagtaggactg
cccatcttatacttctctgggaggcgggagcggctgctgctgcgtccagaagtgctggct
gagattccccgggaggcgttcacagtggaagcctgggttaaaccggagggaggacagaac
aacccagccatcatcgcaggtgtgtttgataactgctcccacactgtcagtgacaaaggc
tgggccctggggatccgctcagggaaggacaagggaaagcgggatgctcgcttcttcttc
tccctctgcaccgaccgcgtgaagaaagccaccatcttgattagccacagtcgctaccaa
ccaggcacatggacccatgtggcagccacttacgatggacggcacatggccctgtatgtg
gatggcactcaggtggctagcagtctagaccagtctggtcccctgaacagccccttcatg
gcatcttgccgctctttgctcctggggggagacagctctgaggatgggcactatttccgt
ggacacctgggcacactggttttctggtcgaccgccctgccacaaagccattttcagcac
agttctcagcattcaagtggggaggaggaagcgactgacttggtcctgacagcgagcttt
gagcctgtgaacacagagtgggttccctttagagatgagaagtacccacgacttgaggtt
ctccagggctttgagccagagcctgagattctgtcgcctttgcagcccccactctgtggg
caaacagtctgtgacaatgtggaattgatctcccagtacaatggatactggccccttcgg
ggagagaaggtgatacgctaccaggtggtgaacatctgtgatgatgagggcctaaacccc
attgtgagtgaggagcagattcgtctgcagcacgaggcactgaatgaggccttcagccgc
tacaacatcagctggcagctgagcgtccaccaggtccacaattccaccctgcgacaccgg
gttgtgcttgtgaactgtgagcccagcaagattggcaatgaccattgtgaccccgagtgt
gagcacccactcacaggctatgatgggggtgactgccgcctgcagggccgctgctactcc
tggaaccgcagggatgggctctgtcacgtggagtgtaacaacatgctgaacgactttgac
gacggagactgctgcgacccccaggtggctgatgtgcgcaagacctgctttgaccctgac
tcacccaagagggcatacatgagtgtgaaggagctgaaggaggccctgcagctgaacagt
actcacttcctcaacatctactttgccagctcagtgcgggaagaccttgcaggtgctgcc
acctggccttgggacaaggacgctgtcactcacctgggtggcattgtcctcagcccagca
tattatgggatgcctggccacaccgacaccatgatccatgaagtgggacatgttctggga
ctctaccatgtctttaaaggagtcagtgaaagagaatcctgcaatgacccctgcaaggag
acagtgccatccatggaaacgggagacctctgtgccgacaccgcccccactcccaagagt
gagctgtgccgggaaccagagcccactagtgacacctgtggcttcactcgcttcccaggg
gctccgttcaccaactacatgagctacacggatgataactgcactgacaacttcactcct
aaccaagtggcccgaatgcattgctatttggacctagtctatcagcagtggactgaaagc
agaaagcccacccccatccccattccacctatggtcatcggacagaccaacaagtccctc
actatccactggctgcctcctattagtggagttgtatatgacagggcctcaggcagcttg
tgtggcgcttgcactgaagatgggacctttcgtcagtatgtgcacacagcttcctcccgg
cgggtgtgtgactcctcaggttattggaccccagaggaggctgtggggcctcctgatgtg
gatcagccctgcgagccaagcttacaggcctggagccctgaggtccacctgtaccacatg
aacatgacggtcccctgccccacagaaggctgtagcttggagctgctcttccaacacccg
gtccaagccgacaccctcaccctgtgggtcacttccttcttcatggagtcctcgcaggtc
ctctttgacacagagatcttgctggaaaacaaggagtcagtgcacctgggccccttagac
actttctgtgacatcccactcaccatcaaactgcacgtggatgggaaggtgtcgggggtg
aaagtctacacctttgatgagaggatagagattgatgcagcactcctgacttctcagccc
cacagtcccttgtgctctggctgcaggcctgtgaggtaccaggttctccgcgatccccca
tttgccagtggtttgcccgtggtggtgacacattctcacaggaagttcacggacgtggag
gtcacacctggacagatgtatcagtaccaagttctagctgaagctggaggagaactggga
gaagcttcgcctcctctgaaccacattcatggagctccttattgtggagatgggaaggtg
tcagagagactgggagaagagtgtgatgatggagaccttgtgagcggagatggctgctcc
aaggtgtgtgagctggaggaaggtttcaactgtgtaggagagccaagcctttgctacatg
tatgagggagatggcatatgtgaaccttttgagagaaaaaccagcattgtagactgtggc
atctacactcccaaaggatacttggatcaatgggctacccgggcttactcctctcatgaa
gacaagaagaagtgtcctgtttccttggtaactggagaacctcattccctaatttgcaca
tcataccatccagatttacccaaccaccgtcccctaactggctggtttccctgtgttgcc
agtgaaaatgaaactcaggatgacaggagtgaacagccagaaggtagcctgaagaaagag
gatgaggtttggctcaaagtgtgtttcaatagaccaggagaggccagagcaatttttatt
tttttgacaactgatggcctagttcccggagagcatcagcagccgacagtgactctctac
ctgaccgatgtccgtggaagcaaccactctcttggaacctatggactgtcatgccagcat
aatccactgattatcaatgtgacccatcaccagaatgtccttttccaccataccacctca
gtgctgctgaatttctcatccccacgggtcggcatctcagctgtggctctaaggacatcc
tcccgcattggtctttcggctcccagtaactgcatctcagaggacgaggggcagaatcat
cagggacagagctgtatccatcggccctgtgggaagcaggacagctgtccgtcattgctg
cttgatcatgctgatgtggtgaactgtacctctataggcccaggtctcatgaagtgtgct
atcacttgtcaaaggggatttgcccttcaggccagcagtgggcagtacatcaggcccatg
cagaaggaaattctgctcacatgttcttctgggcactgggaccagaatgtgagctgcctt
cccgtggactgcggtgttcccgacccgtctttggtgaactatgcaaacttctcctgctca
gagggaaccaaatttctgaaacgctgctcaatctcttgtgtcccaccagccaagctgcaa
ggactgagcccatggctgacatgtcttgaagatggtctctggtctctccctgaagtctac
tgcaagttggagtgtgatgctccccctattattctgaatgccaacttgctcctgcctcac
tgcctccaggacaaccacgacgtgggcaccatctgcaaatatgaatgcaaaccagggtac
tatgtggcagaaagtgcagagggtaaagtcaggaacaagctcctgaagatacaatgcctg
gaaggtggaatctgggagcaaggcagctgcattcctgtggtgtgtgagccaccccctcct
gtgtttgaaggcatgtatgaatgtaccaatggcttcagcctggacagccagtgtgtgctc
aactgtaaccaggaacgtgaaaagcttcccatcctctgcactaaagagggcctgtggacc
caggagtttaagttgtgtgagaatctgcaaggagaatgcccaccacccccctcagagctg
aattctgtggagtacaaatgtgaacaaggatatgggattggtgcagtgtgttccccattg
tgtgtaatcccccccagtgaccccgtgatgctacctgagaatatcactgctgacactctg
gagcactggatggaacctgtcaaagtccagagcattgtgtgcactggccggcgtcaatgg
cacccagaccccgtcttagtccactgcatccagtcatgtgagcccttccaagcagatggt
tggtgtgacactatcaacaaccgagcctactgccactatgacgggggagactgctgctct
tccacactctcctccaagaaggtcattccatttgctgctgactgtgacctggatgagtgc
acctgccgggaccccaaggcagaagaaaatcagtaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (41)   
   KEGG ORTHOLOGY (1)   
   RefGene (34)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (38)   
   RefSeq(nuc) (14)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (10)   
   Pfam (10)   
All databases (111)   

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