KEGG   Homo sapiens (human): 6097
Entry
6097              CDS       T01001                                 
Symbol
RORC, IMD42, NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Name
(RefSeq) RAR related orphan receptor C
  KO
K08534  RAR-related orphan receptor gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa04659  Th17 cell differentiation
hsa04710  Circadian rhythm
hsa05321  Inflammatory bowel disease
Disease
H00089  IFN-gamma/IL-12 axis
Drug target
Cedirogant: D12274
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    6097 (RORC)
  09159 Environmental adaptation
   04710 Circadian rhythm
    6097 (RORC)
 09160 Human Diseases
  09163 Immune disease
   05321 Inflammatory bowel disease
    6097 (RORC)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6097 (RORC)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    6097 (RORC)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    6097 (RORC)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1F. RAR-related orphan receptor
   6097 (RORC)
SSDB
Motif
Pfam: zf-C4 Hormone_recep PX
Other DBs
NCBI-GeneID: 6097
NCBI-ProteinID: NP_005051
OMIM: 602943
HGNC: 10260
Ensembl: ENSG00000143365
UniProt: P51449 Q6I9R9
Structure
Position
1:complement(151806071..151831802)
AA seq 518 aa
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
NT seq 1557 nt   +upstreamnt  +downstreamnt
atggacagggccccacagagacagcaccgagcctcacgggagctgctggctgcaaagaag
acccacacctcacaaattgaagtgatcccttgcaaaatctgtggggacaagtcgtctggg
atccactacggggttatcacctgtgaggggtgcaagggcttcttccgccggagccagcgc
tgtaacgcggcctactcctgcacccgtcagcagaactgccccatcgaccgcaccagccga
aaccgatgccagcactgccgcctgcagaaatgcctggcgctgggcatgtcccgagatgct
gtcaagttcggccgcatgtccaagaagcagagggacagcctgcatgcagaagtgcagaaa
cagctgcagcagcggcaacagcagcaacaggaaccagtggtcaagacccctccagcaggg
gcccaaggagcagataccctcacctacaccttggggctcccagacgggcagctgcccctg
ggctcctcgcctgacctgcctgaggcttctgcctgtccccctggcctcctgaaagcctca
ggctctgggccctcatattccaacaacttggccaaggcagggctcaatggggcctcatgc
caccttgaatacagccctgagcggggcaaggctgagggcagagagagcttctatagcaca
ggcagccagctgacccctgaccgatgtggacttcgttttgaggaacacaggcatcctggg
cttggggaactgggacagggcccagacagctacggcagccccagtttccgcagcacaccg
gaggcaccctatgcctccctgacagagatagagcacctggtgcagagcgtctgcaagtcc
tacagggagacatgccagctgcggctggaggacctgctgcggcagcgctccaacatcttc
tcccgggaggaagtgactggctaccagaggaagtccatgtgggagatgtgggaacggtgt
gcccaccacctcaccgaggccattcagtacgtggtggagttcgccaagaggctctcaggc
tttatggagctctgccagaatgaccagattgtgcttctcaaagcaggagcaatggaagtg
gtgctggttaggatgtgccgggcctacaatgctgacaaccgcacggtcttttttgaaggc
aaatacggtggcatggagctgttccgagccttgggctgcagcgagctcatcagctccatc
tttgacttctcccactccctaagtgccttgcacttttccgaggatgagattgccctctac
acagcccttgttctcatcaatgcccatcggccagggctccaagagaaaaggaaagtagaa
cagctgcagtacaatctggagctggcctttcatcatcatctctgcaagactcatcgccaa
agcatcctggcaaagctgccacccaaggggaagcttcggagcctgtgtagccagcatgtg
gaaaggctgcagatcttccagcacctccaccccatcgtggtccaagccgctttccctcca
ctctacaaggagctcttcagcactgaaaccgagtcacctgtggggctgtccaagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (42)   
   RefSeq(nuc) (6)   
   GenBank (18)   
   EMBL (18)   
3D Structure (155)   
   PDB (155)   
Protein domain (3)   
   Pfam (3)   
All databases (240)   

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