KEGG   Homo sapiens (human): 6197
Entry
6197              CDS       T01001                                 
Symbol
RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, XLID19, p90-RSK2, pp90RSK2
Name
(RefSeq) ribosomal protein S6 kinase A3
  KO
K04373  ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04114  Oocyte meiosis
hsa04150  mTOR signaling pathway
hsa04714  Thermogenesis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04931  Insulin resistance
hsa05135  Yersinia infection
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06526  MAPK signaling
  Element
N01601  ERK-RSK signaling
Disease
H00480  X-linked intellectual developmental disorder
H00574  Coffin-Lowry syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    6197 (RPS6KA3)
   04150 mTOR signaling pathway
    6197 (RPS6KA3)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    6197 (RPS6KA3)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    6197 (RPS6KA3)
  09156 Nervous system
   04720 Long-term potentiation
    6197 (RPS6KA3)
   04722 Neurotrophin signaling pathway
    6197 (RPS6KA3)
  09159 Environmental adaptation
   04714 Thermogenesis
    6197 (RPS6KA3)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    6197 (RPS6KA3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    6197 (RPS6KA3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    6197 (RPS6KA3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6197 (RPS6KA3)
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    6197 (RPS6KA3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6197 (RPS6KA3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   6197 (RPS6KA3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     6197 (RPS6KA3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like Kdo ABC1 Pkinase_fungal Pkinase_C Haspin_kinase APH YrbL-PhoP_reg
Other DBs
NCBI-GeneID: 6197
NCBI-ProteinID: NP_004577
OMIM: 300075
HGNC: 10432
Ensembl: ENSG00000177189
UniProt: P51812 A0A384MDW3
Structure
Position
X:complement(20149911..20267097)
AA seq 740 aa
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH
EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD
ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV
NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR
MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE
FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD
GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK
DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL
KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD
IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML
HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP
VGRSTLAQRRGIKKITSTAL
NT seq 2223 nt   +upstreamnt  +downstreamnt
atgccgctggcgcagctggcggacccgtggcagaagatggctgtggagagcccgtccgac
agcgctgagaatggacagcaaattatggatgaacctatgggagaggaggagattaaccca
caaactgaagaagtcagtatcaaagaaattgcaatcacacatcatgtaaaggaaggacat
gaaaaggcagatccttcccagtttgaacttttaaaagtattagggcagggatcatttgga
aaggttttcttagttaaaaaaatctcaggctctgatgctaggcagctttatgccatgaag
gtattgaagaaggccacactgaaagttcgagaccgagttcggacaaaaatggaacgtgat
atcttggtagaggttaatcatccttttattgtcaagttgcattatgcttttcaaactgaa
gggaagttgtatcttattttggattttctcaggggaggagatttgtttacacgcttatcc
aaagaggtgatgttcacagaagaagatgtcaaattctacttggctgaacttgcacttgct
ttagaccatctacatagcctgggaataatttatagagacttaaaaccagaaaatatactt
cttgatgaagaaggtcacatcaagttaacagatttcggcctaagtaaagagtctattgac
catgaaaagaaggcatattctttttgtggaactgtggagtatatggctccagaagtagtt
aatcgtcgaggtcatactcagagtgctgactggtggtcttttggtgtgttaatgtttgaa
atgcttactggtacactccctttccaaggaaaagatcgaaaagaaacaatgactatgatt
cttaaagccaaacttggaatgccacagtttttgagtcctgaagcgcagagtcttttacga
atgcttttcaagcgaaatcctgcaaacagattaggtgcaggaccagatggagttgaagaa
attaaaagacattcatttttctcaacgatagactggaataaactgtatagaagagaaatt
catccgccatttaaacctgcaacgggcaggcctgaagatacattctattttgatcctgag
tttactgcaaaaactcccaaagattcacctggcattccacctagtgctaatgcacatcag
ctttttcgggggtttagttttgttgctattacctcagatgatgaaagccaagctatgcag
acagttggtgtacattcaattgttcagcagttacacaggaacagtattcagtttactgat
ggatatgaagtaaaagaagatattggagttggctcctactctgtttgcaagagatgtata
cataaagctacaaacatggagtttgcagtgaagattattgataaaagcaagagagaccca
acagaagaaattgaaattcttcttcgttatggacagcatccaaacattatcactctaaag
gatgtatatgatgatggaaagtatgtgtatgtagtaacagaacttatgaaaggaggtgaa
ttgctggataaaattcttagacaaaaatttttctctgaacgagaggccagtgctgtcctg
ttcactataactaaaaccgttgaatatcttcacgcacaaggggtggttcatagagacttg
aaacctagcaacattctttatgtggatgaatctggtaatccggaatctattcgaatttgt
gattttggctttgcaaaacagctgagagcggaaaatggtcttctcatgactccttgttac
actgcaaattttgttgcaccagaggttttaaaaagacaaggctatgatgctgcttgtgat
atatggagtcttggtgtcctactctatacaatgcttaccggttacactccatttgcaaat
ggtcctgatgatacaccagaggaaatattggcacgaataggtagcggaaaattctcactc
agtggtggttactggaattctgtttcagacacagcaaaggacctggtgtcaaagatgctt
catgtagaccctcatcagagactgactgctgctcttgtgctcagacatccttggatcgtc
cactgggaccaactgccacaataccaactaaacagacaggatgcaccacatctagtaaag
ggtgccatggcagctacatattctgctttgaaccgtaatcagtcaccagttttggaacca
gtaggccgctctactcttgctcagcggagaggtattaaaaaaatcacctcaacagccctg
tga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (37)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (34)   
DNA sequence (80)   
   RefSeq(nuc) (34)   
   GenBank (23)   
   EMBL (23)   
3D Structure (12)   
   PDB (12)   
Protein domain (10)   
   Pfam (10)   
All databases (178)   

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