KEGG   Homo sapiens (human): 6258
Entry
6258              CDS       T01001                                 
Symbol
RXRG, NR2B3, RXR-gamma, RXRC, RXRgamma
Name
(RefSeq) retinoid X receptor gamma
  KO
K08526  retinoid X receptor gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa03320  PPAR signaling pathway
hsa04659  Th17 cell differentiation
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05216  Thyroid cancer
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05226  Gastric cancer
hsa05417  Lipid and atherosclerosis
Network
nt06240  Transcription (cancer)
nt06274  Thyroid cancer
nt06322  TRH-TSH-TH signaling
  Element
N00126  PAX8-PPARG fusion to PPARG-mediated transcription
N00798  Thyroid hormone signaling pathway
Drug target
Acitretin: D02754<US>
Adapalene: D01112<JP/US>
Alitretinoin: D02815<US>
Bexarotene: D03106<JP/US>
Etretinate: D00316<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    6258 (RXRG)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    6258 (RXRG)
   03320 PPAR signaling pathway
    6258 (RXRG)
   04919 Thyroid hormone signaling pathway
    6258 (RXRG)
   04928 Parathyroid hormone synthesis, secretion and action
    6258 (RXRG)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6258 (RXRG)
   05202 Transcriptional misregulation in cancer
    6258 (RXRG)
   05207 Chemical carcinogenesis - receptor activation
    6258 (RXRG)
  09162 Cancer: specific types
   05226 Gastric cancer
    6258 (RXRG)
   05216 Thyroid cancer
    6258 (RXRG)
   05222 Small cell lung cancer
    6258 (RXRG)
   05223 Non-small cell lung cancer
    6258 (RXRG)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    6258 (RXRG)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6258 (RXRG)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    6258 (RXRG)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 hepatocyte nuclear factor 4-like
    6258 (RXRG)
Nuclear receptors [BR:hsa03310]
 2. Hepatocyte nuclear factor 4 like
  2B. Retinoid X receptor (RXR)
   6258 (RXRG)
SSDB
Motif
Pfam: Nuc_recep-AF1 Hormone_recep zf-C4 CRT10
Other DBs
NCBI-GeneID: 6258
NCBI-ProteinID: NP_008848
OMIM: 180247
HGNC: 10479
Ensembl: ENSG00000143171
UniProt: P48443 F1D8Q7
Structure
Position
1:complement(165400922..165445126)
AA seq 463 aa
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
NT seq 1392 nt   +upstreamnt  +downstreamnt
atgtatggaaattattctcacttcatgaagtttcccgcaggctatggaggctcccctggc
cacactggctctacatccatgagcccatcagcagccttgtccacagggaagccaatggac
agccaccccagctacacagataccccagtgagtgccccacggactctgagtgcagtgggg
acccccctcaatgccctgggctctccatatcgagtcatcacctctgccatgggcccaccc
tcaggagcacttgcagcgcctccaggaatcaacttggttgccccacccagctctcagcta
aatgtggtcaacagtgtcagcagttcagaggacatcaagcccttaccagggcttcccggg
attggaaacatgaactacccatccaccagccccggatctctggttaaacacatctgtgcc
atctgtggagacagatcctcaggaaagcactacggggtatacagttgtgaaggctgcaaa
gggttcttcaagaggacgataaggaaggacctcatctacacgtgtcgggataataaagac
tgcctcattgacaagcgtcagcgcaaccgctgccagtactgtcgctatcagaagtgcctt
gtcatgggcatgaagagggaagctgtgcaagaagaaagacagaggagccgagagcgagct
gagagtgaggcagaatgtgctaccagtggtcatgaagacatgcctgtggagaggattcta
gaagctgaacttgctgttgaaccaaagacagaatcctatggtgacatgaatatggagaac
tcgacaaatgaccctgttaccaacatatgtcatgctgctgacaagcagcttttcaccctc
gttgaatgggccaagcgtattccccacttctctgacctcaccttggaggaccaggtcatt
ttgcttcgggcagggtggaatgaattgctgattgcctctttctcccaccgctcagtttcc
gtgcaggatggcatccttctggccacgggtttacatgtccaccggagcagtgcccacagt
gctggggtcggctccatctttgacagagtcctaactgagctggtttccaaaatgaaagac
atgcagatggacaagtcggaactgggatgcctgcgagccattgtactctttaacccagat
gccaagggcctgtccaacccctctgaggtggagactctgcgagagaaggtttatgccacc
cttgaggcctacaccaagcagaagtatccggaacagccaggcaggtttgccaagctgctg
ctgcgcctcccagctctgcgttccattggcttgaaatgcctggagcacctcttcttcttc
aagctcatcggggacacccccattgacaccttcctcatggagatgttggagaccccgctg
cagatcacctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (13)   
   KEGG PATHWAY (13)   
Network (5)   
   KEGG NETWORK (5)   
Disease (1)   
   OMIM (1)   
Drug (5)   
   KEGG DRUG (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (38)   
   RefSeq(nuc) (4)   
   GenBank (17)   
   EMBL (17)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   Pfam (4)   
All databases (91)   

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