KEGG   Homo sapiens (human): 629
Entry
629               CDS       T01001                                 
Symbol
CFB, AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2
Name
(RefSeq) complement factor B
  KO
K01335  complement factor B [EC:3.4.21.47]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
hsa05150  Staphylococcus aureus infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06513  Complement cascade
  Element
N01493  Alternative pathway of complement cascade, C3 convertase formation
N01494  Alternative pathway of complement cascade, C3/5 convertase formation
Disease
H00104  Alternative complement pathway component defects
H00821  Age-related macular degeneration
H01434  Atypical hemolytic uremic syndrome
Drug target
Iptacopan (DG03207): D12251 D12252<US>
Ruxoprubart: D12857
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    629 (CFB)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    629 (CFB)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    629 (CFB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    629 (CFB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.47  alternative-complement-pathway C3/C5 convertase
     629 (CFB)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   629 (CFB)
SSDB
Motif
Pfam: Trypsin VWA Sushi VWA_2 DUF1986 HRM Trypsin_2
Other DBs
NCBI-GeneID: 629
NCBI-ProteinID: NP_001701
OMIM: 138470
HGNC: 1037
Ensembl: ENSG00000243649
CPD: C22540
UniProt: P00751 A0A1U9X7H8
Structure
Position
6:31946095..31952084
AA seq 764 aa
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
NT seq 2295 nt   +upstreamnt  +downstreamnt
atggggagcaatctcagcccccaactctgcctgatgccctttatcttgggcctcttgtct
ggaggtgtgaccaccactccatggtctttggcccggccccagggatcctgctctctggag
ggggtagagatcaaaggcggctccttccgacttctccaagagggccaggcactggagtac
gtgtgtccttctggcttctacccgtaccctgtgcagacacgtacctgcagatctacgggg
tcctggagcaccctgaagactcaagaccaaaagactgtcaggaaggcagagtgcagagca
atccactgtccaagaccacacgacttcgagaacggggaatactggccccggtctccctac
tacaatgtgagtgatgagatctctttccactgctatgacggttacactctccggggctct
gccaatcgcacctgccaagtgaatggccgatggagtgggcagacagcgatctgtgacaac
ggagcggggtactgctccaacccgggcatccccattggcacaaggaaggtgggcagccag
taccgccttgaagacagcgtcacctaccactgcagccgggggcttaccctgcgtggctcc
cagcggcgaacgtgtcaggaaggtggctcttggagcgggacggagccttcctgccaagac
tccttcatgtacgacacccctcaagaggtggccgaagctttcctgtcttccctgacagag
accatagaaggagtcgatgctgaggatgggcacggcccaggggaacaacagaagcggaag
atcgtcctggacccttcaggctccatgaacatctacctggtgctagatggatcagacagc
attggggccagcaacttcacaggagccaaaaagtgtctagtcaacttaattgagaaggtg
gcaagttatggtgtgaagccaagatatggtctagtgacatatgccacataccccaaaatt
tgggtcaaagtgtctgaagcagacagcagtaatgcagactgggtcacgaagcagctcaat
gaaatcaattatgaagaccacaagttgaagtcagggactaacaccaagaaggccctccag
gcagtgtacagcatgatgagctggccagatgacgtccctcctgaaggctggaaccgcacc
cgccatgtcatcatcctcatgactgatggattgcacaacatgggcggggacccaattact
gtcattgatgagatccgggacttgctatacattggcaaggatcgcaaaaacccaagggag
gattatctggatgtctatgtgtttggggtcgggcctttggtgaaccaagtgaacatcaat
gctttggcttccaagaaagacaatgagcaacatgtgttcaaagtcaaggatatggaaaac
ctggaagatgttttctaccaaatgatcgatgaaagccagtctctgagtctctgtggcatg
gtttgggaacacaggaagggtaccgattaccacaagcaaccatggcaggccaagatctca
gtcattcgcccttcaaagggacacgagagctgtatgggggctgtggtgtctgagtacttt
gtgctgacagcagcacattgtttcactgtggatgacaaggaacactcaatcaaggtcagc
gtaggaggggagaagcgggacctggagatagaagtagtcctatttcaccccaactacaac
attaatgggaaaaaagaagcaggaattcctgaattttatgactatgacgttgccctgatc
aagctcaagaataagctgaaatatggccagactatcaggcccatttgtctcccctgcacc
gagggaacaactcgagctttgaggcttcctccaactaccacttgccagcaacaaaaggaa
gagctgctccctgcacaggatatcaaagctctgtttgtgtctgaggaggagaaaaagctg
actcggaaggaggtctacatcaagaatggggataagaaaggcagctgtgagagagatgct
caatatgccccaggctatgacaaagtcaaggacatctcagaggtggtcacccctcggttc
ctttgtactggaggagtgagtccctatgctgaccccaatacttgcagaggtgattctggc
ggccccttgatagttcacaagagaagtcgtttcattcaagttggtgtaatcagctgggga
gtagtggatgtctgcaaaaaccagaagcggcaaaagcaggtacctgctcacgcccgagac
tttcacatcaacctctttcaagtgctgccctggctgaaggagaaactccaagatgaggat
ttgggttttctataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (3)   
   KEGG NETWORK (3)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (37)   
   RefSeq(nuc) (1)   
   GenBank (18)   
   EMBL (18)   
3D Structure (24)   
   PDB (24)   
Protein domain (7)   
   Pfam (7)   
All databases (114)   

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