KEGG   Homo sapiens (human): 6336
Entry
6336              CDS       T01001                                 
Symbol
SCN10A, FEPS2, Nav1.8, PN3, SNS
Name
(RefSeq) sodium voltage-gated channel alpha subunit 10
  KO
K04842  voltage-gated sodium channel type X alpha
Organism
hsa  Homo sapiens (human)
Disease
H01391  Familial episodic pain syndrome
Drug target
Actisomide: D02762
Ajmaline: D00199
Aminobenzoic acid (DG00379): D02456 D02906 D02907
Amiodarone (DG00204): D00636<JP/US> D02910
Aprindine (DG00199): D01326<JP> D02969
Articaine (DG00805): D02991 D07468
Benzocaine: D00552<JP>
Bliretrigine: D12616
Bupivacaine (DG00801): D01450<JP/US> D07552<US>
Carbamazepine: D00252<JP/US>
Cenobamate: D11150<US>
Chloroprocaine (DG00800): D00732<US> D07678
Cibenzoline (DG00209): D01455<JP> D03492
Cinchocaine (DG00297): D00733 D02220
Cocaine (DG00808): D00110 D02182<US>
Disopyramide (DG00194): D00303<JP> D00637<JP/US>
Eleclazine: D11155
Encainide (DG00203): D03991 D07894
Eslicarbazepine (DG00848): D09215 D09612<US>
Ethyl piperidinoacetylaminobenzoate: D01519
Etidocaine (DG00804): D00737 D04095
Flecainide (DG00201): D00638<JP/US> D07962
Fosphenytoin (DG00847): D02096<US> D07595<JP> D07993
Indecainide hydrochloride: D04521
Lacosamide: D07299<JP/US>
Lamotrigine: D00354<JP/US>
Levobupivacaine (DG00807): D01287<JP> D08116
Levosemotiadil fumarate: D09833
Lidocaine (DG00196): D00358<JP/US> D02086<JP/US> D08127<JP/US>
Lorajmine: D04774
Mephenytoin: D00375
Mepivacaine (DG00802): D00738<JP/US> D08181
Mexiletine (DG00197): D00639<JP/US> D08215
Oxcarbazepine: D00533<US>
Oxetacaine (DG00299): D01152<JP> D08311
Oxybuprocaine (DG00392): D01768<JP> D08319
Phenytoin (DG00846): D00512<JP/US> D02103<JP/US>
Pilsicainide (DG01257): D01554<JP> D08377
Pirmenol (DG01381): D01785<JP> D06517 D08394
Pramocaine (DG00300): D00739 D08407
Prilocaine (DG00803): D00553 D01243<US>
Procainamide (DG00193): D00477<JP/US> D08421
Procaine (DG00298): D00740<JP> D08422
Propafenone (DG00200): D00640<JP/US> D08435
Proxymetacaine (DG01145): D02098<US> D08448
Quinidine (DG00192): D00642<US> D00643 D02272<JP/US> D08458 D08459
Recainam (DG01421): D05708 D05709
Ropivacaine (DG00806): D04048<JP/US> D08490
Rufinamide: D05775<JP/US>
Sparteine (DG00195): D01041 D02239
Suzetrigine: D12860
Tetracaine (DG00296): D00551 D00741<US>
Tocainide (DG00198): D02088 D06172
Topiramate: D00537<JP/US>
Transcainide: D06203
Zonisamide: D00538<JP/US>
p-Butylaminobenzoyldiethylaminoethyl hydrochloride: D01967
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    6336 (SCN10A)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Sodium channel, voltage-gated (Nav)
   6336 (SCN10A)
SSDB
Motif
Pfam: Ion_trans Na_trans_assoc PKD_channel Na_trans_cytopl GPHH CcmD_alt Zip
Other DBs
NCBI-GeneID: 6336
NCBI-ProteinID: NP_006505
OMIM: 604427
HGNC: 10582
Ensembl: ENSG00000185313
UniProt: Q9Y5Y9
Structure
Position
3:complement(38696807..38816217)
AA seq 1956 aa
MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKAC
NQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIR
RTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLN
EFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALI
HSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYIN
KRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWER
LYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQE
ALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSD
PYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLG
GGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEY
LDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFG
LVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFD
PYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKII
GNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFL
IVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTA
PEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAEN
HIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSF
QQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDD
TSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQ
VRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFE
MLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRA
LSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSL
VPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSR
EVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQK
KYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQ
SEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAIL
KSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFI
YSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDP
NLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDD
FDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHC
LDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQK
AYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPS
YESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP
NT seq 5871 nt   +upstreamnt  +downstreamnt
atggaattccccattggatccctcgaaactaacaacttccgtcgctttactccggagtca
ctggtggagatagagaagcaaattgctgccaagcagggaacaaagaaagccagagagaag
catagggagcagaaggaccaagaagagaagcctcggccccagctggacttgaaagcctgc
aaccagctgcccaagttctatggtgagctcccagcagaactgatcggggagcccctggag
gatctagatccgttctacagcacacaccggacatttatggtgctgaacaaagggaggacc
atttcccggtttagtgccactcgggccctgtggctattcagtcctttcaacctgatcaga
agaacggccatcaaagtgtctgtccactcgtggttcagtttatttattacggtcactatt
ttggttaattgtgtgtgcatgacccgaactgaccttccagagaaaattgaatatgtcttc
actgtcatttacacctttgaagccttgataaagatactggcaagaggattttgtctaaat
gagttcacgtacctgagagatccttggaactggctggattttagcgtcattaccctggca
tatgttggcacagcaatagatctccgtgggatctcaggcctgcggacattcagagttctt
agagcattaaaaacagtttctgtgatcccaggcctgaaggtcattgtgggggccctgatt
cactcagtgaagaaactggctgatgtgaccatcctcaccatcttctgcctaagtgttttt
gccttggtggggctgcaactcttcaagggcaacctcaaaaataaatgtgtcaagaatgac
atggctgtcaatgagacaaccaactactcatctcacagaaaaccagatatctacataaat
aagcgaggcacttctgaccccttactgtgtggcaatggatctgactcaggccactgccct
gatggttatatctgccttaaaacttctgacaacccggattttaactacaccagctttgat
tcctttgcttgggctttcctctcactgttccgcctcatgacacaggattcctgggaacgc
ctctaccagcagaccctgaggacttctgggaaaatctatatgatcttttttgtgctcgta
atcttcctgggatctttctacctggtcaacttgatcttggctgtagtcaccatggcgtat
gaggagcagaaccaggcaaccactgatgaaattgaagcaaaggagaagaagttccaggag
gccctcgagatgctccggaaggagcaggaggtgctagcagcactagggattgacacaacc
tctctccactcccacaatggatcacctttaacctccaaaaatgccagtgagagaaggcat
agaataaagccaagagtgtcagagggctccacagaagacaacaaatcaccccgctctgat
ccttacaaccagcgcaggatgtcttttctaggcctcgcctctggaaaacgccgggctagt
catggcagtgtgttccatttccggtcccctggccgagatatctcactccctgagggagtc
acagatgatggagtctttcctggagaccacgaaagccatcggggctctctgctgctgggt
gggggtgctggccagcaaggccccctccctagaagccctcttcctcaacccagcaaccct
gactccaggcatggagaagatgaacaccaaccgccgcccactagtgagcttgcccctgga
gctgtcgatgtctcggcattcgatgcaggacaaaagaagactttcttgtcagcagaatac
ttagatgaacctttccgggcccaaagggcaatgagtgttgtcagtatcataacctccgtc
cttgaggaactcgaggagtctgaacagaagtgcccaccctgcttgaccagcttgtctcag
aagtatctgatctgggattgctgccccatgtgggtgaagctcaagacaattctctttggg
cttgtgacggatccctttgcagagctcaccatcaccttgtgcatcgtggtgaacaccatc
ttcatggccatggagcaccatggcatgagccctaccttcgaagccatgctccagataggc
aacatcgtctttaccatattttttactgctgaaatggtcttcaaaatcattgccttcgac
ccatactattatttccagaagaagtggaatatctttgactgcatcatcgtcactgtgagt
ctgctagagctgggcgtggccaagaagggaagcctgtctgtgctgcggagcttccgcttg
ctgcgcgtattcaagctggccaaatcctggcccaccttaaacacactcatcaagatcatc
ggaaactcagtgggggcactggggaacctcaccatcatcctggccatcattgtctttgtc
tttgctctggttggcaagcagctcctaggggaaaactaccgtaacaaccgaaaaaatatc
tccgcgccccatgaagactggccccgctggcacatgcacgacttcttccactctttcctc
attgtcttccgtatcctctgtggagagtggattgagaacatgtgggcctgcatggaagtt
ggccaaaaatccatatgcctcatccttttcttgacggtgatggtgctagggaacctggtg
gtgcttaacctgttcatcgccctgctattgaactctttcagtgctgacaacctcacagcc
ccggaggacgatggggaggtgaacaacctgcaggtggccctggcacggatccaggtcttt
ggccatcgtaccaaacaggctctttgcagcttcttcagcaggtcctgcccattcccccag
cccaaggcagagcctgagctggtggtgaaactcccactctccagctccaaggctgagaac
cacattgctgccaacactgccagggggagctctggagggctccaagctcccagaggcccc
agggatgagcacagtgacttcatcgctaatccgactgtgtgggtctctgtgcccattgct
gagggtgaatctgatcttgatgacttggaggatgatggtggggaagatgctcagagcttc
cagcaggaagtgatccccaaaggacagcaggagcagctgcagcaagtcgagaggtgtggg
gaccacctgacacccaggagcccaggcactggaacatcttctgaggacctggctccatcc
ctgggtgagacgtggaaagatgagtctgttcctcaggtccctgctgagggagtggacgac
acaagctcctctgagggcagcacggtggactgcctagatcctgaggaaatcctgaggaag
atccctgagctggcagatgacctggaagaaccagatgactgcttcacagaaggatgcatt
cgccactgtccctgctgcaaactggataccaccaagagtccatgggatgtgggctggcag
gtgcgcaagacttgctaccgtatcgtggagcacagctggtttgagagcttcatcatcttc
atgatcctgctcagcagtggatctctggcctttgaagactattacctggaccagaagccc
acggtgaaagctttgctggagtacactgacagggtcttcacctttatctttgtgttcgag
atgctgcttaagtgggtggcctatggcttcaaaaagtacttcaccaatgcctggtgctgg
ctggacttcctcattgtgaatatctcactgataagtctcacagcgaagattctggaatat
tctgaagtggctcccatcaaagcccttcgaacccttcgcgctctgcggccactgcgggct
ctttctcgatttgaaggcatgcgggtggtggtggatgccctggtgggcgccatcccatcc
atcatgaatgtcctcctcgtctgcctcatcttctggctcatcttcagcatcatgggtgtg
aacctcttcgcagggaagttttggaggtgcatcaactataccgatggagagttttccctt
gtacctttgtcgattgtgaataacaagtctgactgcaagattcaaaactccactggcagc
ttcttctgggtcaatgtgaaagtcaactttgataatgttgcaatgggttaccttgcactt
ctgcaggtggcaacctttaaaggctggatggacattatgtatgcagctgttgattcccgg
gaggtcaacatgcaacccaagtgggaggacaacgtgtacatgtatttgtactttgtcatc
ttcatcatttttggaggcttcttcacactgaatctctttgttggggtcataattgacaac
ttcaatcaacagaaaaaaaagttagggggccaggacatcttcatgacagaggagcagaag
aaatactacaatgccatgaagaagttgggctccaagaagccccagaagcccatcccacgg
cccctgaacaagttccagggttttgtctttgacatcgtgaccagacaagcttttgacatc
accatcatggtcctcatctgcctcaacatgatcaccatgatggtggagactgatgaccaa
agtgaagaaaagacgaaaattctgggcaaaatcaaccagttctttgtggccgtcttcaca
ggcgaatgtgtcatgaagatgttcgctttgaggcagtactacttcacaaatggctggaat
gtgtttgacttcattgtggtggttctctccattgcgagcctgattttttctgcaattctt
aagtcacttcaaagttacttctccccaacgctcttcagagtcatccgcctggcccgaatt
ggccgcatcctcagactgatccgagcggccaaggggatccgcacactgctctttgccctc
atgatgtccctgcctgccctcttcaacatcgggctgttgctattccttgtcatgttcatc
tactctatcttcggtatgtccagctttccccatgtgaggtgggaggctggcatcgacgac
atgttcaacttccagaccttcgccaacagcatgctgtgcctcttccagattaccacgtcg
gccggctgggatggcctcctcagccccatcctcaacacagggcccccctactgtgacccc
aatctgcccaacagcaatggcaccagaggggactgtgggagcccagccgtaggcatcatc
ttcttcaccacctacatcatcatctccttcctcatcatggtcaacatgtacattgcagtg
attctggagaacttcaatgtggccacggaggagagcactgagcccctgagtgaggacgac
tttgacatgttctatgagacctgggagaagtttgacccagaggccactcagtttattacc
ttttctgctctctcggactttgcagacactctctctggtcccctgagaatcccaaaaccc
aatcgaaatatactgatccagatggacctgcctttggtccctggagataagatccactgc
ttggacatcctttttgctttcaccaagaatgtcctaggagaatccggggagttggattct
ctgaaggcaaatatggaggagaagtttatggcaactaatctttcaaaatcatcctatgaa
ccaatagcaaccactctccgatggaagcaagaagacatttcagccactgtcattcaaaag
gcctatcggagctatgtgctgcaccgctccatggcactctctaacaccccatgtgtgccc
agagctgaggaggaggctgcatcactcccagatgaaggttttgttgcattcacagcaaat
gaaaattgtgtactcccagacaaatctgaaactgcttctgccacatcattcccaccgtcc
tatgagagtgtcactagaggccttagtgatagagtcaacatgaggacatctagctcaata
caaaatgaagatgaagccaccagtatggagctgattgcccctgggccctag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (100)   
   KEGG DRUG (100)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (11)   
   RefSeq(nuc) (9)   
   GenBank (1)   
   EMBL (1)   
3D Structure (4)   
   PDB (4)   
Protein domain (7)   
   Pfam (7)   
All databases (172)   

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