| Entry |
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| Symbol |
CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B
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| Name |
(RefSeq) C-X-C motif chemokine ligand 12
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| KO |
| K10031 | C-X-C motif chemokine 12 |
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| Organism |
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| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04061 | Viral protein interaction with cytokine and cytokine receptor |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05163 | Human cytomegalovirus infection |
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| Network |
nt06161 Human immunodeficiency virus 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06167 Human cytomegalovirus (HCMV) nt06227 Nuclear receptor signaling (cancer) nt06263 Hepatocellular carcinoma nt06533 Chemokine signaling |
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| Element |
| N00401 | CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway |
| N00405 | CXCR4-GNA12/13-Rho signaling pathway |
| N00413 | CXCR4-GNB/G-PLCB-PKC signaling pathway |
| N00430 | CXCR4-GNAI-PI3K-BAD signaling pathway |
| N00433 | CXCR4-GNB/G-RAC signaling pathway |
| N00546 | CXCL12-CXCR4-PKC-ERK signaling pathaway |
| N01362 | Nuclear-initiated progesterone signaling pathway |
| N01765 | CXCR4-GNAQ-PLCB/G signaling pathway |
| N01767 | CXCR4-GNAI-Src signaling pathway |
| N01768 | CXCR4-GNA12/13 signaling pathway |
| N01771 | CXCR4-GNB/G signaling pathway |
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| Disease |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
6387 (CXCL12)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
6387 (CXCL12)
04061 Viral protein interaction with cytokine and cytokine receptor
6387 (CXCL12)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
6387 (CXCL12)
09150 Organismal Systems
09151 Immune system
04670 Leukocyte transendothelial migration
6387 (CXCL12)
04672 Intestinal immune network for IgA production
6387 (CXCL12)
04062 Chemokine signaling pathway
6387 (CXCL12)
09158 Development and regeneration
04360 Axon guidance
6387 (CXCL12)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6387 (CXCL12)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
6387 (CXCL12)
09163 Immune disease
05323 Rheumatoid arthritis
6387 (CXCL12)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:hsa04052]
6387 (CXCL12)
00536 Glycosaminoglycan binding proteins [BR:hsa00536]
6387 (CXCL12)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
Chemokines
6387 (CXCL12)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
Chemokines
6387 (CXCL12)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
10:complement(44370165..44385097)
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| AA seq |
93 aa
MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIV
ARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM |
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| NT seq |
282 nt +upstreamnt +downstreamnt
atgaacgccaaggtcgtggtcgtgctggtcctcgtgctgaccgcgctctgcctcagcgac
gggaagcccgtcagcctgagctacagatgcccatgccgattcttcgaaagccatgttgcc
agagccaacgtcaagcatctcaaaattctcaacactccaaactgtgcccttcagattgta
gcccggctgaagaacaacaacagacaagtgtgcattgacccgaagctaaagtggattcag
gagtacctggagaaagctttaaacaagaggttcaagatgtga |
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