KEGG   Homo sapiens (human): 640
Entry
640               CDS       T01001                                 
Symbol
BLK, MODY11
Name
(RefSeq) BLK proto-oncogene, Src family tyrosine kinase
  KO
K08890  B lymphoid tyrosine kinase [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04662  B cell receptor signaling pathway
Disease
H00410  Maturity onset diabetes of the young (MODY)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    640 (BLK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    640 (BLK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     640 (BLK)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  SRC family
   640 (BLK)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_9 SH3_2 SH3_3 SH3_16 Haspin_kinase ABC1
Other DBs
NCBI-GeneID: 640
NCBI-ProteinID: NP_001706
OMIM: 191305
HGNC: 1057
Ensembl: ENSG00000136573
UniProt: P51451 Q05D26
Position
8:11494387..11564599
AA seq 505 aa
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
NT seq 1518 nt   +upstreamnt  +downstreamnt
atggggctggtaagtagcaaaaagccggacaaggaaaagccgatcaaagagaaggacaag
ggccaatggagccccctgaaggtcagcgcccaagacaaggacgccccgccactgccgccc
ctggttgtcttcaaccaccttactcctccaccgcccgatgaacacctggatgaagacaag
catttcgtggtggctctgtatgactacaccgctatgaatgatcgggacctgcagatgctg
aagggggagaagctacaggtcctgaagggaactggagactggtggctggccaggtcactc
gtcacaggaagagaaggctatgtgcccagtaactttgtggcccgagtggagagcctggaa
atggaaaggtggttctttagatcacagggtcggaaggaggctgagaggcagcttcttgct
ccaatcaacaaggccggctcctttcttatcagagagagtgaaaccaacaaaggtgccttc
tccctgtctgtgaaggatgtcaccacccagggggagctgatcaagcactataagatccgc
tgcctggatgaagggggctactacatctccccccggatcaccttcccctcgctccaggcc
ctggtgcagcactattctaagaagggggatggtctatgccagaggctgaccctgccctgt
gtgcgcccggccccgcagaatccctgggcccaggatgaatgggagatcccccggcagtct
ctcaggctggtcaggaaactcgggtctggacaattcggcgaagtctggatgggttactac
aaaaacaacatgaaggtggccattaagacgctgaaggagggaaccatgtctccagaagcc
tttctgggtgaggccaacgtgatgaaggctctgcagcacgagcggctggtccgactctac
gcagtggtcaccaaggagcccatctacattgtcaccgagtacatggccagaggatgcctg
ctggatttcctgaagacagatgaagggagcagattgtcactcccaaggctgattgacatg
tcggcgcagattgctgaagggatggcatacattgagcgcatgaattccatccaccgcgac
ctgcgggcggccaacatcctggtgtctgaggccttgtgctgcaaaattgctgattttggc
ttggctcgaatcatcgacagtgaatacacggcccaagagggggccaagttccccatcaag
tggacagccccggaagccatccacttcggggtcttcaccatcaaagcagacgtgtggtcg
tttggagtcctcctgatggaagttgtcacttatgggcgggtgccatacccagggatgagc
aaccccgaggtcatccgcaacctggagcgcggctaccgcatgccgcgccccgacacctgc
ccgcccgagctgtaccgcggcgtcatcgccgagtgctggcgcagccggcccgaggagcgg
cccaccttcgagttcctgcagtcggtgctggaggacttctacacggccaccgagcggcag
tacgagctgcagccctag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (29)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (26)   
DNA sequence (46)   
   RefSeq(nuc) (26)   
   GenBank (10)   
   EMBL (10)   
Protein domain (10)   
   Pfam (10)   
All databases (108)   

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