KEGG   Homo sapiens (human): 6469
Entry
6469              CDS       T01001                                 
Symbol
SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, ShhNC, TPT, TPTPS
Name
(RefSeq) sonic hedgehog signaling molecule
  KO
K11988  sonic hedgehog
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
hsa04360  Axon guidance
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05217  Basal cell carcinoma
hsa05226  Gastric cancer
Network
nt06217  HH signaling (cancer)
nt06240  Transcription (cancer)
nt06261  Gastric cancer
nt06269  Basal cell carcinoma
nt06501  HH signaling
  Element
N00062  Hedgehog signaling pathway
N00251  CDX2-overexpression to transcriptional repression
N01537  Hedgehog signaling pathway, HH ligand secretion
N01538  Hedgehog signaling pathway, PTCH coreceptor
Disease
H00267  Holoprosencephaly
H00652  Solitary median maxillary central incisor syndrome
H01027  Microphthalmia
H01160  Schizencephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    6469 (SHH)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    6469 (SHH)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6469 (SHH)
   05205 Proteoglycans in cancer
    6469 (SHH)
  09162 Cancer: specific types
   05226 Gastric cancer
    6469 (SHH)
   05217 Basal cell carcinoma
    6469 (SHH)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    6469 (SHH)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    6469 (SHH)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C46: hedgehog family
   6469 (SHH)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Morphogens
   6469 (SHH)
SSDB
Motif
Pfam: HH_signal Hint Peptidase_M15_3 Ribosomal_S6e
Other DBs
NCBI-GeneID: 6469
NCBI-ProteinID: NP_000184
OMIM: 600725
HGNC: 10848
Ensembl: ENSG00000164690
UniProt: Q15465
Structure
Position
7:complement(155799980..155812463)
AA seq 462 aa
MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV
KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAH
IHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLT
FLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALG
PRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVL
ASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGA
ADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
NT seq 1389 nt   +upstreamnt  +downstreamnt
atgctgctgctggcgagatgtctgctgctagtcctcgtctcctcgctgctggtatgctcg
ggactggcgtgcggaccgggcagggggttcgggaagaggaggcaccccaaaaagctgacc
cctttagcctacaagcagtttatccccaatgtggccgagaagaccctaggcgccagcgga
aggtatgaagggaagatctccagaaactccgagcgatttaaggaactcacccccaattac
aaccccgacatcatatttaaggatgaagaaaacaccggagcggacaggctgatgactcag
aggtgtaaggacaagttgaacgctttggccatctcggtgatgaaccagtggccaggagtg
aaactgcgggtgaccgagggctgggacgaagatggccaccactcagaggagtctctgcac
tacgagggccgcgcagtggacatcaccacgtctgaccgcgaccgcagcaagtacggcatg
ctggcccgcctggcggtggaggccggcttcgactgggtgtactacgagtccaaggcacat
atccactgctcggtgaaagcagagaactcggtggcggccaaatcgggaggctgcttcccg
ggctcggccacggtgcacctggagcagggcggcaccaagctggtgaaggacctgagcccc
ggggaccgcgtgctggcggcggacgaccagggccggctgctctacagcgacttcctcact
ttcctggaccgcgacgacggcgccaagaaggtcttctacgtgatcgagacgcgggagccg
cgcgagcgcctgctgctcaccgccgcgcacctgctctttgtggcgccgcacaacgactcg
gccaccggggagcccgaggcgtcctcgggctcggggccgccttccgggggcgcactgggg
cctcgggcgctgttcgccagccgcgtgcgcccgggccagcgcgtgtacgtggtggccgag
cgtgacggggaccgccggctcctgcccgccgctgtgcacagcgtgaccctaagcgaggag
gccgcgggcgcctacgcgccgctcacggcccagggcaccattctcatcaaccgggtgctg
gcctcgtgctacgcggtcatcgaggagcacagctgggcgcaccgggccttcgcgcccttc
cgcctggcgcacgcgctcctggctgcactggcgcccgcgcgcacggaccgcggcggggac
agcggcggcggggaccgcgggggcggcggcggcagagtagccctaaccgctccaggtgct
gccgacgctccgggtgcgggggccaccgcgggcatccactggtactcgcagctgctctac
caaataggcacctggctcctggacagcgaggccctgcacccgctgggcatggcggtcaag
tccagctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Network (9)   
   KEGG NETWORK (9)   
Disease (9)   
   KEGG DISEASE (4)   
   OMIM (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (32)   
   RefSeq(nuc) (10)   
   GenBank (11)   
   EMBL (11)   
3D Structure (16)   
   PDB (16)   
Protein domain (4)   
   Pfam (4)   
All databases (100)   

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