KEGG   Homo sapiens (human): 64750
Entry
64750             CDS       T01001                                 
Symbol
SMURF2
Name
(RefSeq) SMAD specific E3 ubiquitin protein ligase 2
  KO
K04678  E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04137  Mitophagy - animal
hsa04144  Endocytosis
hsa04340  Hedgehog signaling pathway
hsa04350  TGF-beta signaling pathway
hsa04520  Adherens junction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    64750 (SMURF2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    64750 (SMURF2)
   04350 TGF-beta signaling pathway
    64750 (SMURF2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    64750 (SMURF2)
   04137 Mitophagy - animal
    64750 (SMURF2)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    64750 (SMURF2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    64750 (SMURF2)
   04121 Ubiquitin system [BR:hsa04121]
    64750 (SMURF2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    64750 (SMURF2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     64750 (SMURF2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    64750 (SMURF2)
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    64750 (SMURF2)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   64750 (SMURF2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    64750 (SMURF2)
SSDB
Motif
Pfam: HECT WW C2 GpA_nuclease
Other DBs
NCBI-GeneID: 64750
NCBI-ProteinID: NP_073576
OMIM: 605532
HGNC: 16809
Ensembl: ENSG00000108854
UniProt: Q9HAU4 Q96DE7
Structure
Position
17:complement(64542282..64662307)
AA seq 748 aa
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPK
WNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKL
GPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRN
YMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLP
PGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDT
ECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWK
RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHL
SYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEND
ITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLA
LQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSNIVKWFWKAV
EFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRI
DIPPYESYEKLYEKLLTAIEETCGFAVE
NT seq 2247 nt   +upstreamnt  +downstreamnt
atgtctaaccccggaggccggaggaacgggcccgtcaagctgcgcctgacagtactctgt
gcaaaaaacctggtgaaaaaggattttttccgacttcctgatccatttgctaaggtggtg
gttgatggatctgggcaatgccattctacagatactgtgaagaatacgcttgatccaaag
tggaatcagcattatgacctgtatattggaaagtctgattcagttacgatcagtgtatgg
aatcacaagaagatccataagaaacaaggtgctggatttctcggttgtgttcgtcttctt
tccaatgccatcaaccgcctcaaagacactggttatcagaggttggatttatgcaaactc
gggccaaatgacaatgatacagttagaggacagatagtagtaagtcttcagtccagagac
cgaataggcacaggaggacaagttgtggactgcagtcgtttatttgataacgatttacca
gacggctgggaagaaaggagaaccgcctctggaagaatccagtatctaaaccatataaca
agaactacgcaatgggagcgcccaacacgaccggcatccgaatattctagccctggcaga
cctcttagctgctttgttgatgagaacactccaattagtggaacaaatggtgcaacatgt
ggacagtcttcagatcccaggctggcagagaggagagtcaggtcacaacgacatagaaat
tacatgagcagaacacatttacatactcctccagacctaccagaaggctatgaacagagg
acaacgcaacaaggccaggtgtatttcttacatacacagactggtgtgagcacatggcat
gatccaagagtgcccagggatcttagcaacatcaattgtgaagagcttggtccattgcct
cctggatgggagatccgtaatacggcaacaggcagagtttatttcgttgaccataacaac
agaacaacacaatttacagatcctcggctgtctgctaacttgcatttagttttaaatcgg
cagaaccaattgaaagaccaacagcaacagcaagtggtatcgttatgtcctgatgacaca
gaatgcctgacagtcccaaggtacaagcgagacctggttcagaaactaaaaattttgcgg
caagaactttcccaacaacagcctcaggcaggtcattgccgcattgaggtttccagggaa
gagatttttgaggaatcatatcgacaggtcatgaaaatgagaccaaaagatctctggaag
cgattaatgataaaatttcgtggagaagaaggccttgactatggaggcgttgccagggaa
tggttgtatctcttgtcacatgaaatgttgaatccatactatggcctcttccagtattca
agagatgatatttatacattgcagatcaatcctgattctgcagttaatccggaacattta
tcctatttccactttgttggacgaataatgggaatggctgtgtttcatggacattatatt
gatggtggtttcacattgcctttttataagcaattgcttgggaagtcaattaccttggat
gacatggagttagtagatccggatcttcacaacagtttagtgtggatacttgagaatgat
attacaggtgttttggaccataccttctgtgttgaacataatgcatatggtgaaattatt
cagcatgaacttaaaccaaatggcaaaagtatccctgttaatgaagaaaataaaaaagaa
tatgtcaggctctatgtgaactggagatttttacgaggcattgaggctcaattcttggct
ctgcagaaaggatttaatgaagtaattccacaacatctgctgaagacatttgatgagaag
gagttagagctcattatttgtggacttggaaagatagatgttaatgactggaaggtaaac
acccggttaaaacactgtacaccagacagcaacattgtcaaatggttctggaaagctgtg
gagttttttgatgaagagcgacgagcaagattgcttcagtttgtgacaggatcctctcga
gtgcctctgcagggcttcaaagcattgcaaggtgctgcaggcccgagactctttaccata
caccagattgatgcctgcactaacaacctgccgaaagcccacacttgcttcaatcgaata
gacattccaccctatgaaagctatgaaaagctatatgaaaagctgctaacagccattgaa
gaaacatgtggatttgctgtggaatga

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (36)   
   RefSeq(nuc) (8)   
   GenBank (14)   
   EMBL (14)   
3D Structure (7)   
   PDB (7)   
Protein domain (4)   
   Pfam (4)   
All databases (90)   

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