KEGG   Homo sapiens (human): 65018
Entry
65018             CDS       T01001                                 
Symbol
PINK1, BRPK, PARK6
Name
(RefSeq) PTEN induced kinase 1
  KO
K05688  PTEN induced putative kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06536  Mitophagy
  Element
N01043  Mutation-inactivated PINK1 to electron transfer in Complex I
N01048  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01050  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01052  PINK1-Parkin-mediated MFN2 degradation
N01053  Mutation-inactivated PINK1 to PINK1-Parkin-mediated MFN2 degradation
N01137  PINK-Parkin-mediated autophagosome formation
N01138  Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
N01757  PINK-Parkin-independent ubiquitin-mediated mitophagy, ubiquitin E3 ligase
Disease
H00057  Parkinson disease
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    65018 (PINK1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    65018 (PINK1)
   05014 Amyotrophic lateral sclerosis
    65018 (PINK1)
   05022 Pathways of neurodegeneration - multiple diseases
    65018 (PINK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    65018 (PINK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    65018 (PINK1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    65018 (PINK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     65018 (PINK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  NKF2 family
   65018 (PINK1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    65018 (PINK1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    65018 (PINK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like APH
Other DBs
NCBI-GeneID: 65018
NCBI-ProteinID: NP_115785
OMIM: 608309
HGNC: 14581
Ensembl: ENSG00000158828
UniProt: Q9BXM7
Position
1:20633458..20651511
AA seq 581 aa
MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVG
LGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRR
AVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQ
NLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQE
LVPASRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLP
SRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAH
RDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVST
ARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPP
DVRQLVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKLDKMVGWLLQQSAATLL
ANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRAAL
NT seq 1746 nt   +upstreamnt  +downstreamnt
atggcggtgcgacaggcgctgggccgcggcctgcagctgggtcgagcgctgctgctgcgc
ttcacgggcaagcccggccgggcctacggcttggggcggccgggcccggcggcgggctgt
gtccgcggggagcgtccaggctgggccgcaggaccgggcgcggagcctcgcagggtcggg
ctcgggctccctaaccgtctccgcttcttccgccagtcggtggccgggctggcggcgcgg
ttgcagcggcagttcgtggtgcgggcctggggctgcgcgggcccttgcggccgggcagtc
tttctggccttcgggctagggctgggcctcatcgaggaaaaacaggcggagagccggcgg
gcggtctcggcctgtcaggagatccaggcaatttttacccagaaaagcaagccggggcct
gacccgttggacacgagacgcttgcagggctttcggctggaggagtatctgatagggcag
tccattggtaagggctgcagtgctgctgtgtatgaagccaccatgcctacattgccccag
aacctggaggtgacaaagagcaccgggttgcttccagggagaggcccaggtaccagtgca
ccaggagaagggcaggagcgagctccgggggcccctgccttccccttggccatcaagatg
atgtggaacatctcggcaggttcctccagcgaagccatcttgaacacaatgagccaggag
ctggtcccagcgagccgagtggccttggctggggagtatggagcagtcacttacagaaaa
tccaagagaggtcccaagcaactagcccctcaccccaacatcatccgggttctccgcgcc
ttcacctcttccgtgccgctgctgccaggggccctggtcgactaccctgatgtgctgccc
tcacgcctccaccctgaaggcctgggccatggccggacgctgttcctcgttatgaagaac
tatccctgtaccctgcgccagtacctttgtgtgaacacacccagcccccgcctcgccgcc
atgatgctgctgcagctgctggaaggcgtggaccatctggttcaacagggcatcgcgcac
agagacctgaaatccgacaacatccttgtggagctggacccagacggctgcccctggctg
gtgatcgcagattttggctgctgcctggctgatgagagcatcggcctgcagttgcccttc
agcagctggtacgtggatcggggcggaaacggctgtctgatggccccagaggtgtccacg
gcccgtcctggccccagggcagtgattgactacagcaaggctgatgcctgggcagtggga
gccatcgcctatgaaatcttcgggcttgtcaatcccttctacggccagggcaaggcccac
cttgaaagccgcagctaccaagaggctcagctacctgcactgcccgagtcagtgcctcca
gacgtgagacagttggtgagggcactgctccagcgagaggccagcaagagaccatctgcc
cgagtagccgcaaatgtgcttcatctaagcctctggggtgaacatattctagccctgaag
aatctgaagttagacaagatggttggctggctcctccaacaatcggccgccactttgttg
gccaacaggctcacagagaagtgttgtgtggaaacaaaaatgaagatgctctttctggct
aacctggagtgtgaaacgctctgccaggcagccctcctcctctgctcatggagggcagcc
ctgtga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (14)   
   KEGG NETWORK (14)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
Protein domain (4)   
   Pfam (4)   
All databases (70)   

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