KEGG   Homo sapiens (human): 6502
Entry
6502              CDS       T01001                                 
Symbol
SKP2, FBL1, FBXL1, FLB1, p45
Name
(RefSeq) S-phase kinase associated protein 2
  KO
K03875  F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04120  Ubiquitin mediated proteolysis
hsa04150  mTOR signaling pathway
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
hsa05222  Small cell lung cancer
Network
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06230  Cell cycle (cancer)
nt06261  Gastric cancer
nt06267  Small cell lung cancer
nt06272  Prostate cancer
  Element
N00091  p27-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00264  EBV EBNA3C to p27-Cell cycle G1/S
N00484  EBV EBNA3C to cell cycle G1/S
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    6502 (SKP2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    6502 (SKP2)
   04150 mTOR signaling pathway
    6502 (SKP2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    6502 (SKP2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6502 (SKP2)
   05203 Viral carcinogenesis
    6502 (SKP2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    6502 (SKP2)
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    6502 (SKP2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6502 (SKP2)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Target recognizing subunit (F-box)
     6502 (SKP2)
SSDB
Motif
Pfam: F-box-like F-box FBXL18_LRR F-box_5 LRR_8
Other DBs
NCBI-GeneID: 6502
NCBI-ProteinID: NP_005974
OMIM: 601436
HGNC: 10901
Ensembl: ENSG00000145604
UniProt: Q13309
Structure
Position
5:36152111..36193530
AA seq 424 aa
MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG
HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV
SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP
FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC
SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS
DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP
TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK
PSCL
NT seq 1275 nt   +upstreamnt  +downstreamnt
atgcacaggaagcacctccaggagattccagacctgagtagcaacgttgccaccagcttc
acgtggggatgggattccagcaagacttctgaactgctgtcaggcatgggggtctccgcc
ctggagaaagaggagcccgacagtgagaacatcccccaggaactgctctcaaacctgggc
cacccggagagccccccacggaaacggctgaagagcaaagggagtgacaaagactttgtg
attgtccgcaggcctaagctaaatcgagagaactttccaggtgtttcatgggactccctt
ccggatgagctgctcttgggaatcttttcctgtctgtgcctccctgagctgctaaaggtc
tctggtgtttgtaagaggtggtatcgcctagcgtctgatgagtctctatggcagacctta
gacctcacaggtaaaaatctgcacccggatgtgactggtcggttgctgtctcaaggggtg
attgccttccgctgcccacgatcatttatggaccaaccattggctgaacatttcagccct
tttcgtgtacagcacatggacctatcgaactcagttatagaagtgtccaccctccacggc
atactgtctcagtgttccaagttgcagaatctaagcctggaaggcctgcggctttcggat
cccattgtcaatactctcgcaaaaaactcaaatttagtgcgacttaacctttctgggtgt
tctggattctctgaatttgccctgcagactttgctaagcagctgttccagactggatgag
ctgaacctctcctggtgttttgatttcactgaaaagcatgtacaggtggctgttgcgcat
gtgtcagagaccatcacccagctgaatcttagcggctacagaaagaatctccagaaatca
gatctctctactttagttagaagatgccccaatcttgtccatctagacttaagtgatagt
gtcatgctaaagaatgactgctttcaggaatttttccagctcaactacctccaacaccta
tcactcagtcggtgctatgatataatacctgaaactttacttgaacttggagaaattccc
acactaaaaacactacaagtttttggaatcgtgccagatggtacccttcaactgttaaag
gaagcccttcctcatctacagattaattgctcccatttcaccaccattgccaggccaact
attggcaacaaaaagaaccaggagatatggggcatcaaatgccgactgacactgcaaaag
cccagttgtctatga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (8)   
Network (10)   
   KEGG NETWORK (10)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (34)   
   RefSeq(nuc) (8)   
   GenBank (13)   
   EMBL (13)   
3D Structure (21)   
   PDB (21)   
Protein domain (5)   
   Pfam (5)   
All databases (118)   

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