KEGG   Homo sapiens (human): 6524
Entry
6524              CDS       T01001                                 
Symbol
SLC5A2, SGLT2
Name
(RefSeq) solute carrier family 5 member 2
  KO
K14382  solute carrier family 5 (sodium/glucose cotransporter), member 2
Organism
hsa  Homo sapiens (human)
Disease
H01126  Familial renal glucosuria
Drug target
Bexagliflozin: D10865<US>
Canagliflozin: D09592<JP/US>
Dapagliflozin (DG00122): D08897 D09763<JP/US>
Empagliflozin: D10459<JP/US>
Ertugliflozin (DG02836): D10313 D11043<US>
Ipragliflozin (DG01248): D10196 D10200<JP>
Luseogliflozin: D10195<JP>
Remogliflozin etabonate: D10055
Sergliflozin etabonate: D06641
Sotagliflozin: D10669<US>
Tofogliflozin: D09978<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6524 (SLC5A2)
   04147 Exosome [BR:hsa04147]
    6524 (SLC5A2)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC5: Sodium glucose cotransporter
   6524 (SLC5A2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   6524 (SLC5A2)
SSDB
Motif
Pfam: SSF
Other DBs
NCBI-GeneID: 6524
NCBI-ProteinID: NP_003032
OMIM: 182381
HGNC: 11037
Ensembl: ENSG00000140675
UniProt: P31639
Structure
Position
16:31483123..31490769
AA seq 672 aa
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
NT seq 2019 nt   +upstreamnt  +downstreamnt
atggaggagcacacagaggcaggctcggcaccagagatgggggcccagaaggccctgatt
gacaatcctgctgacatcctagtcattgctgcatatttcctgctggtcattggcgttggc
ttgtggtccatgtgcagaaccaacagaggcactgtgggcggctacttcctggcaggacgc
agcatggtgtggtggccggttggggcctctctcttcgccagcaacatcggcagtggccac
tttgtgggcctggcagggactggcgctgcaagtggcttggctgttgctggattcgagtgg
aatgcgctcttcgtggtgctgctactgggctggctgtttgcacccgtgtacctgacagcg
ggggtcatcacgatgccacagtacctgcgcaagcgcttcggcggccgccgcatccgcctc
tacctgtctgtgctctcccttttcctgtacatcttcaccaagatctcagtggacatgttc
tccggagctgtattcatccagcaggctctgggctggaacatctatgcctccgtcatcgcg
cttctgggcatcaccatgatttacacggtgacaggagggctggccgcgctgatgtacacg
gacacggtacagaccttcgtcattctggggggcgcctgcatcctcatgggttacgccttc
cacgaggtgggcgggtattcgggtctcttcgacaaatacctgggagcagcgacttcgctg
acggtgtccgaggatccagccgtgggaaacatctccagcttctgctatcgaccccggccc
gactcctaccacctgctccggcaccccgtgaccggggatctgccgtggcccgcgctgctc
ctcggactcacaatcgtctcgggctggtactggtgcagcgaccaggtcatcgtgcagcgc
tgcctggccgggaagagcctgacccacatcaaggcgggctgcatcctgtgtgggtacctg
aagctgacgcccatgtttctcatggtcatgccaggcatgatcagccgcattctgtaccca
gacgaggtggcgtgcgtggtgcctgaggtgtgcaggcgcgtgtgcggcacggaggtgggc
tgctccaacatcgcctacccgcggctcgtcgtgaagctcatgcccaacggtctgcgcgga
ctcatgctggcggtcatgctggccgcgctcatgtcctcgctggcctccatcttcaacagc
agcagcacgctcttcaccatggacatctacacgcgcctgcggccacgcgccggcgaccgc
gagctgctgctggtgggacggctctgggtggtgttcatcgtggtagtgtcggtggcctgg
cttcccgtggtgcaggcggcacagggcgggcagctcttcgattacatccaggcagtctct
agctacctggcaccgcccgtgtccgccgtcttcgtgctggcgctcttcgtgccgcgcgtt
aatgagcagggcgccttctggggactcatcgggggcctgctgatgggcctggcacgcctg
attcccgagttctccttcggctcgggcagctgtgtgcagccctcggcgtgcccagctttc
ctctgcggcgtgcactacctctacttcgccattgtgctgttcttctgctctggcctcctc
accctcacggtctccctgtgcaccgcgcccatccccagaaagcacctccaccgcctggtc
ttcagtctccggcatagcaaggaggaacgggaggacctggatgctgatgagcagcaaggc
tcctcactccctgtacagaatgggtgcccagagagtgccatggagatgaatgagccccag
gccccggcaccaagcctcttccgccagtgcctgctctggttttgtggaatgagcagaggt
ggggtgggcagtcctccgccccttacccaggaggaggcagcggcagcagccaggcggctg
gaggacatcagcgaggacccgagctgggcccgtgtggtcaacctcaatgccctgctcatg
atggcagtggccgtgttcctctggggcttctatgcctaa

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (14)   
   KEGG DRUG (14)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (14)   
   RefSeq(nuc) (6)   
   GenBank (4)   
   EMBL (4)   
3D Structure (8)   
   PDB (8)   
Protein domain (1)   
   Pfam (1)   
All databases (65)   

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