KEGG T01001: 6530

Homo sapiens (human): 6530

Entry

6530              CDS       T01001

Symbol

SLC6A2, NAT1, NET, NET1, SLC6A5

Name

(RefSeq) solute carrier family 6 member 2

K05035

solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2

Organism

hsa Homo sapiens (human)

Pathway

hsa04721

Synaptic vesicle cycle

Disease

H01031

Orthostatic intolerance

Drug target

Amezinium metilsulfate:

D01304<JP>

Amfepramone (DG00104):

D03801<US> D07444

Amfetamine (DG00966):

D02074<US> D07445<US>

Amitifadine (DG01386):

D10088 D10089

Amitriptyline (DG00934):

D00809<JP/US> D07448

Amitriptylinoxide:

D07449

Amoxapine:

D00228<JP/US>

Amphetamine aspartate monohydrate:

D11622

Ampreloxetine (DG03081):

D11688 D11689

Atomoxetine (DG00970):

D02574<JP/US> D07473

Benzfetamine (DG01755):

D07514 D07515<US>

Bupropion (DG00957):

D00817<US> D07591 D07938<US>

Centanafadine (DG01858):

D10697 D10698

Cidoxepin hydrochloride:

D03491

Clomipramine (DG00929):

D00811<JP/US> D07727

Cocaine (DG00808):

D00110 D02182<US>

Dasotraline (DG01989):

D10700 D10870

Desipramine (DG00927):

D00812<US> D07791

Desvenlafaxine (DG00963):

D02570<US> D07793<US> D11619<US>

Dexamfetamine (DG00967):

D02078<US> D03740<US>

Dexmethylphenidate (DG00972):

D03721<US> D07806

Dextroamphetamine saccharate:

D11623

Dosulepin (DG00940):

D01546<JP> D07872

Doxepin (DG00937):

D00814<US> D07875

Duloxetine (DG00962):

D01179<JP/US> D07880

Edivoxetine (DG01310):

D09890 D09891

Esreboxetine (DG01309):

D09340 D09341

Guanethidine (DG00258):

D02237 D04382 D08030

Hydroxyamphetamine hydrobromide:

D04473

Imipramine (DG00928):

D00815<JP/US> D08070 D08071<US>

Imipraminoxide (DG01542):

D07334 D08072

Indeloxazine (DG02869):

D02170 D08077

Levomilnacipran (DG01387):

D10072 D10133<US>

Liafensine:

D10443

Lisdexamfetamine (DG00973):

D04747<JP/US> D08130

Lofepramine (DG00932):

D01285<JP> D08140

Lortalamine:

D04781

Maprotiline (DG00941):

D00818<JP> D02566

Mazindol:

D00367<JP>

Metamfetamine (DG00968):

D02242<JP/US> D08187

Methylphenidate (DG00969):

D01296<JP/US> D04999<US>

Midomafetamine:

D11172

Milnacipran (DG00960):

D01107<JP/US> D08222

Napamezole hydrochloride:

Napitane mesylate:

Nisoxetine:

Nomifensine:

Nortriptyline (DG00935):

D00816<JP/US> D08288

Oxaprotiline hydrochloride:

D05284

Phendimetrazine (DG01537):

D02080<US> D08347 D08348

Phenmetrazine hydrochloride:

D05454

Phentermine (DG00102):

D05458 D05459<US>

Protriptyline (DG00936):

D00484<US> D08447

Pyrovalerone hydrochloride:

D05663

Radafaxine hydrochloride:

D05692

Reboxetine (DG00961):

D02573 D08472

Sibutramine (DG00108):

D02571 D08513

Solriamfetol (DG02989):

D11315 D11328<US>

Talopram hydrochloride:

D05997

Tampramine fumarate:

D02704

Tandamine hydrochloride:

D06004

Tapentadol (DG00826):

D06007 D10199<JP/US>

Tenamfetamine:

D12715

Toludesvenlafaxine (DG03141):

D11940 D11941

Trimipramine (DG00931):

D00394 D02408<JP/US>

Venlafaxine (DG00959):

D00821<JP/US> D08670 D12403<US>

Viloxazine (DG00956):

D02572<US> D08673

Brite

KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
  09156 Nervous system
   04721 Synaptic vesicle cycle
    6530 (SLC6A2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6530 (SLC6A2)
Transporters [BR:hsa02000]
Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6530 (SLC6A2)

SSDB

Motif

Pfam:

SNF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Position

16:55655988..55706192

AA seq 617 aa
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI

NT seq 1854 nt +upstreamnt +downstreamnt
atgcttctggcgcggatgaacccgcaggtgcagcccgagaacaacggggcggacacgggt
ccagagcagccccttcgggcgcgcaaaactgcggagctgctggtggtgaaggagcgcaac
ggcgtccagtgcctgctggcgccccgcgacggcgacgcgcagccccgggagacctggggc
aagaagatcgacttcctgctgtccgtagtcggcttcgcagtggacctggccaacgtgtgg
cgcttcccctacctctgctacaagaacggcggcggtgccttcttgatcccgtacacactg
ttccttatcatcgcggggatgcccctgttctacatggagctggctctgggacagtacaac
cgggagggggctgccaccgtttggaaaatctgcccattcttcaaaggcgttggctatgct
gtcatcctgatcgccctgtacgttggcttctactacaacgtcatcatcgcctggtcactc
tactacctcttctcctccttcaccctcaacctgccctggaccgactgtggccacacctgg
aacagccccaactgtaccgaccccaagctcctcaatggctccgtgcttggcaaccacacc
aagtactccaagtacaagttcacgccggcagccgagttttatgagcgtggtgtcctgcac
cttcacgagagcagcgggattcatgacatcggcctgccccagtggcagctcttgctctgt
ctgatggtcgtcgtcatcgtcttgtattttagcctctggaaaggggtgaagacatcagga
aaggtggtgtggatcacagccacgctgccttacttcgtgctgttcgtgctcctggtccat
ggcgtcacgctgcccggagcctccaatggcatcaatgcctacctgcacatcgacttctac
cgcttgaaagaggccacggtatggattgatgccgcaactcagatatttttttccttgggg
gctggatttggagtattgattgcatttgccagttacaacaaatttgacaacaactgttac
agggatgccctgctgaccagcagcatcaactgtatcaccagcttcgtctctgggttcgcc
atcttctccatccttggttacatggcccatgaacacaaggtcaacattgaggatgtggcc
acagaaggagctggcctagtgttcatcctgtatccagaggccatttctaccctgtctgga
tctacattctgggctgttgtgtttttcgtcatgctcctggcgctgggccttgacagctca
atgggaggcatggaggctgtcatcacgggcctggcagatgacttccaggtcctgaagcga
caccggaaactcttcacatttggcgtcaccttcagcactttccttctcgccctgttctgc
ataaccaagggtggaatttacgtcttgaccctcctggacacctttgctgcgggcacctcc
atcctttttgctgtcctcatggaagccatcggagtttcctggttttatggagtggacagg
ttcagcaacgacatccagcagatgatggggttcaggccgggtctatactggagactgtgc
tggaagttcgtcagtcctgccttcctcctgttcgtggttgtggtcagcatcatcaacttc
aagccactcacctacgacgactacatcttcccgccctgggccaactgggtggggtggggc
atcgccctgtcctccatggtcctggtgcccatctacgtcatctataagttcctcagcacg
cagggctctctttgggagagactggcctatggcatcacgccagagaacgagcaccacctg
gtggctcagagggacatcagacagttccagttgcaacactggctggccatctga

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