KEGG   Homo sapiens (human): 653689
Entry
653689            CDS       T01001                                 
Symbol
GSTT2B, GSTT2P
Name
(RefSeq) glutathione S-transferase theta 2B
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00480  Glutathione metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01524  Platinum drug resistance
hsa05200  Pathways in cancer
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling (cancer)
nt06227  Nuclear receptor signaling (cancer)
nt06250  DNA adduct formation (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01365  TCDD to Ahr signaling pathway
N01386  DCE to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    653689 (GSTT2B)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    653689 (GSTT2B)
   00982 Drug metabolism - cytochrome P450
    653689 (GSTT2B)
   00983 Drug metabolism - other enzymes
    653689 (GSTT2B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    653689 (GSTT2B)
   05204 Chemical carcinogenesis - DNA adducts
    653689 (GSTT2B)
   05207 Chemical carcinogenesis - receptor activation
    653689 (GSTT2B)
   05208 Chemical carcinogenesis - reactive oxygen species
    653689 (GSTT2B)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    653689 (GSTT2B)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    653689 (GSTT2B)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    653689 (GSTT2B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    653689 (GSTT2B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     653689 (GSTT2B)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   653689 (GSTT2B)
SSDB
Motif
Pfam: GST_N GST_N_3 GST_C GST_N_2 GST_C_2 GST_C_3
Other DBs
NCBI-GeneID: 653689
NCBI-ProteinID: NP_001074312
HGNC: 33437
Ensembl: ENSG00000133433
UniProt: P0CG30 G9J6Q5
Structure
Position
22:complement(23957414..23961206)
AA seq 244 aa
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDG
DFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLG
PLIGVQVPEEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALG
YELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRI
ARIP
NT seq 735 nt   +upstreamnt  +downstreamnt
atgggcctagagctgtttcttgacctggtgtcccagcccagccgcgccgtctacatcttc
gccaagaagaatggcatccccttagagctgcgcaccgtggatttggtcaaagggcagcac
aagagcaaggagttcttgcagatcaacagcctggggaaactgccgacgctcaaggatggt
gatttcatcttgaccgaaagctcggccatcctgatttacctgagctgtaagtaccagacg
ccggaccactggtatccatctgacctgcaggctcgtgcccgtgttcatgagtacctgggc
tggcatgccgactgcatccgtggcacctttggtatacccctgtgggtccaggtgttgggg
ccactcattggggtccaggtgcccgaggagaaggtggaacgcaacaggactgccatggac
caggccctgcaatggctggaggacaagttcctgggggacaggcccttcctcgctggccag
caggtgacactggctgatctcatggccctggaggagctgatgcagccggtggctctcggc
tatgaactgtttgagggacggccacgactggcagcatggcgtggacgagtggaggctttc
ctgggtgctgagctatgccaggaggcccacagcatcatcttgagcatcctggaacaggcg
gccaagaaaaccctcccaacaccctcaccagaggcctatcaggctatgctgcttcgaatc
gccaggatcccctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Network (10)   
   KEGG NETWORK (10)   
Chemical substance (45)   
   KEGG COMPOUND (45)   
Chemical reaction (23)   
   KEGG ENZYME (1)   
   KEGG REACTION (22)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
3D Structure (4)   
   PDB (4)   
Protein domain (6)   
   Pfam (6)   
All databases (129)   

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