KEGG   Homo sapiens (human): 6559
Entry
6559              CDS       T01001                                 
Symbol
SLC12A3, NCC, NCCT, TSC
Name
(RefSeq) solute carrier family 12 member 3
  KO
K14426  solute carrier family 12 (sodium/chloride transporter), member 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
Network
nt06325  Hormone/cytokine signaling
  Element
N01823  FGF23-NCC/NPT signaling pathway
Disease
H00240  Gitelman syndrome
Drug target
Bendroflumethiazide: D00650
Benzthiazide: D00651
Benzylhydrochlorothiazide: D01246<JP>
Chlorothiazide (DG00268): D00519<US> D03471<US>
Chlortalidone: D00272<US>
Flumethiazide: D02453
Hydrochlorothiazide: D00340<JP/US>
Hydroflumethiazide: D00654
Indapamide (DG00269): D00345<JP/US> D06401
Mefruside: D01877<JP>
Methyclothiazide: D00656
Meticrane: D01605
Metolazone: D00431<US>
Penflutizide: D01241
Polythiazide: D00657
Quinethazone: D00461
Trichlormethiazide: D00658<JP>
Tripamide: D01895
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    6559 (SLC12A3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    6559 (SLC12A3)
   04147 Exosome [BR:hsa04147]
    6559 (SLC12A3)
Transporters [BR:hsa02000]
 Solute carrier family (SLC)
  SLC12: Electroneutral cation-coupled Cl cotransporter
   6559 (SLC12A3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   6559 (SLC12A3)
SSDB
Motif
Pfam: SLC12 AA_permease AA_permease_N AA_permease_2
Other DBs
NCBI-GeneID: 6559
NCBI-ProteinID: NP_001119580
OMIM: 600968
HGNC: 10912
Ensembl: ENSG00000070915
UniProt: P55017
Structure
Position
16:56865207..56915850
AA seq 1021 aa
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG
EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
TVRDLLQEYGAPIVDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL
NVSKMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDG
GLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHILPDIN
QNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLN
EIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYC
Q
NT seq 3066 nt   +upstreamnt  +downstreamnt
atggcagaactgcccacaacagagacgcctggggacgccactttgtgcagcgggcgcttc
accatcagcacactgctgagcagtgatgagccctctccaccagctgcctatgacagcagc
caccccagccacctgacccacagcagcaccttctgcatgcgcacctttggctacaacacg
atcgatgtggtgcccacatatgagcactatgccaacagcacccagcctggtgagccccgg
aaggtccggcccacactggctgacctgcactccttcctcaagcaggaaggcagacacctg
catgccctggcctttgacagccggcccagccacgagatgactgatgggctggtggagggc
gaggcaggcaccagcagcgagaagaaccccgaggagccagtgcgcttcggctgggtcaag
ggggtgatgattcgttgcatgctcaacatttggggcgtgatcctctacctgcggctgccc
tggattacggcccaggcaggcatcgtcctgacctggatcatcatcctgctgtcggtcacg
gtgacctccatcacaggcctctccatctcagccatctccaccaatggcaaggtcaagtca
ggtggcacctacttcctcatctcccggagtctgggcccagagcttgggggctccatcggc
ctcattttcgctttcgccaatgccgtgggtgtggccatgcacacggtgggctttgcagag
accgtgcgggacctgctccaggagtatggggcacccatcgtggaccccattaacgacatc
cgcatcattgccgtggtctcggtcactgtgctgctggccatctccctggctggcatggag
tgggagtccaaggcccaggtgctgttcttccttgtcatcatggtctcctttgccaactat
ttagtggggacgctgatccccccatctgaggacaaggcctccaaaggcttcttcagctac
cgggcggacatttttgtccagaacttggtgcctgactggcggggtccagatggcaccttc
ttcggaatgttctccatcttcttcccctcggccacaggcatcctggcaggggccaacata
tctggtgacctcaaggaccctgctatagccatccccaaggggaccctcatggccattttc
tggacgaccatttcctacctggccatctcagccaccattggctcctgcgtggtgcgtgat
gcctctggggtcctgaatgacacagtgacccctggctggggtgcctgcgaggggctggcc
tgcagctatggctggaacttcaccgagtgcacccagcagcacagctgccactacggcctc
atcaactattaccagaccatgagcatggtgtcaggcttcgcgcccctgatcacggctggc
atcttcggggccaccctctcctctgccctggcctgccttgtctctgctgccaaagtcttc
cagtgcctttgcgaggaccagctgtacccactgatcggcttcttcggcaaaggctatggc
aagaacaaggagcccgtgcgtggctacctgctggcctacgccatcgctgtggccttcatc
atcatcgctgagctcaacaccatagcccccatcatttccaacttcttcctctgctcctat
gccctcatcaacttcagctgcttccacgcctccatcaccaactcgcctgggtggagacct
tcattccaatactacaacaagtgggcggcgctgtttggggctatcatctccgtggtcatc
atgttcctcctcacctggtgggcggccctcatcgccattggcgtggtgctcttcctcctg
ctctatgtcatctacaagaagccagaggtaaattggggctcctcggtacaggctggctcc
tacaacctggccctcagctactcggtgggcctcaatgaggtggaagaccacatcaagaac
taccgcccccagtgcctggtgctcacggggccccccaacttccgcccggccctggtggac
tttgtgggcaccttcacccggaacctcagcctgatgatctgtggccacgtgctcatcgga
ccccacaagcagaggatgcctgagctccagctcatcgccaacgggcacaccaagtggctg
aacaagaggaagatcaaggccttctactcggatgtcattgccgaggacctccgcagaggc
gtccagatcctcatgcaggccgcaggtctcgggagaatgaagcccaacattctggtggtt
gggttcaagaagaactggcagtcggctcacccggccacagtggaagactacattggcatc
ctccatgatgcctttgatttcaactatggcgtgtgtgtcatgaggatgcgggagggactc
aacgtgtccaagatgatgcaggcgcacattaaccccgtgtttgacccagcggaggacggg
aaggaagccagcgccagagtggaccccaaggccctggtgaaggaggagcaggccaccacc
atcttccagtcggagcagggcaagaagaccatagacatctactggctctttgacgatgga
ggcctcaccctcctcattccctatctccttggccgcaagaggaggtggagcaaatgcaag
atccgtgtgttcgtaggcggccagattaacaggatggaccaggagagaaaggcgatcatt
tctctgctgagcaagttccgactgggattccatgaagtccacatcctccctgacatcaac
cagaaccctcgggctgagcacaccaagaggtttgaggacatgattgcacccttccgtctg
aatgatggcttcaaggatgaggccactgtcaacgagatgcggcgggactgcccctggaag
atctcagatgaggagattacgaagaacagagtcaagtcccttcggcaggtgaggctgaat
gagattgtgctggattactcccgagacgctgctctcatcgtcatcactttgcccataggg
aggaaggggaagtgccccagctcgctgtacatggcctggctggagaccctgtcccaggac
ctcagacctccagtcatcctgatccgaggaaaccaggaaaacgtgctcaccttttactgc
cagtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (20)   
   KEGG DRUG (20)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (14)   
   RefSeq(nuc) (4)   
   GenBank (5)   
   EMBL (5)   
3D Structure (9)   
   PDB (9)   
Protein domain (4)   
   Pfam (4)   
All databases (74)   

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