KEGG   Homo sapiens (human): 6713
Entry
6713              CDS       T01001                                 
Symbol
SQLE
Name
(RefSeq) squalene epoxidase
  KO
K00511  squalene monooxygenase [EC:1.14.14.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00100  Steroid biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00101  Cholesterol biosynthesis, FPP => cholesterol
Network
nt06034  Cholesterol biosynthesis
  Element
N01624  Cholesterol biosynthesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    6713 (SQLE)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.17  squalene monooxygenase
     6713 (SQLE)
SSDB
Motif
Pfam: SE FAD_binding_3 DAO NAD_binding_8 Pyr_redox Pyr_redox_2 FAD_binding_2 TrkA_N ApbA Shikimate_DH 3HCDH_N Sacchrp_dh_NADP Thi4 NAD_Gly3P_dh_N GIDA AlaDh_PNT_C F420_oxidored NAD_binding_2 FAD_oxidored
Other DBs
NCBI-GeneID: 6713
NCBI-ProteinID: NP_003120
OMIM: 602019
HGNC: 11279
Ensembl: ENSG00000104549
UniProt: Q14534 Q5HYI4
Structure
Position
8:124998505..125022283
AA seq 574 aa
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSG
SQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSS
QNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGL
GDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAE
PNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKV
SVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYM
VEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGG
MTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSAT
DDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPW
ITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
NT seq 1725 nt   +upstreamnt  +downstreamnt
atgtggacttttctgggcattgccactttcacctatttttataagaagttcggggacttc
atcactttggccaacagggaggtcctgttgtgcgtgctggtgttcctctcgctgggcctg
gtgctctcctaccgctgtcgccaccgaaacgggggtctcctcgggcgccagcagagcggc
tcccagttcgccctcttctcggatattctctcaggcctgcctttcattggcttcttctgg
gccaaatccccccctgaatcagaaaataaggagcagctcgaggccaggaggcgcagaaaa
ggaaccaatatttcagaaacaagcttaataggaacagctgcctgtacatcaacatcttct
cagaatgacccagaagttatcatcgtgggagctggcgtgcttggctctgctttggcagct
gtgctttccagagatggaagaaaggtgacagtcattgagagagacttaaaagagcctgac
agaatagttggagaattcctgcagccgggtggttatcatgttctcaaagaccttggtctt
ggagatacagtggaaggtcttgatgcccaggttgtaaatggttacatgattcatgatcag
gaaagcaaatcagaggttcagattccttaccctctgtcagaaaacaatcaagtgcagagt
ggaagagctttccatcacggaagattcatcatgagtctccggaaagcagctatggcagag
cccaatgcaaagtttattgaaggtgttgtgttacagttattagaggaagatgatgttgtg
atgggagttcagtacaaggataaagagactggagatatcaaggaactccatgctccactg
actgttgttgcagatgggcttttctccaagttcaggaaaagcctggtctccaataaagtt
tctgtatcatctcattttgttggctttcttatgaagaatgcaccacagtttaaagcaaat
catgctgaacttattttagctaacccgagtccagttctcatctaccagatttcatccagt
gaaactcgagtacttgttgacattagaggagaaatgccaaggaatttaagagaatacatg
gttgaaaaaatttacccacaaatacctgatcacctgaaagaaccattcttagaagccact
gacaattctcatctgaggtccatgccagcaagcttccttcctccttcatcagtgaagaaa
cgaggtgttcttcttttgggagacgcatataatatgaggcatccacttactggtggagga
atgactgttgcttttaaagatataaaactatggagaaaactgctaaagggtatccctgac
ctttatgatgatgcagctattttcgaggccaaaaaatcattttactgggcaagaaaaaca
tctcattcctttgtcgtgaatatccttgctcaggctctttatgaattattttctgccaca
gatgattccctgcatcaactaagaaaagcctgttttctttatttcaaacttggtggcgaa
tgtgttgcgggtcctgttgggctgctttctgtattgtctcctaaccctctagttttaatt
ggacacttctttgctgttgcaatctatgccgtgtatttttgctttaagtcagaaccttgg
attacaaaacctcgagcccttctcagtagtggtgctgtattgtacaaagcgtgttctgta
atatttcctctaatttactcagaaatgaagtatatggttcattaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (2)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (27)   
   RefSeq(nuc) (3)   
   GenBank (12)   
   EMBL (12)   
3D Structure (3)   
   PDB (3)   
Protein domain (19)   
   Pfam (19)   
All databases (87)   

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