KEGG   Homo sapiens (human): 6897
Entry
6897              CDS       T01001                                 
Symbol
TARS1, TARS, TTD7, ThrRS
Name
(RefSeq) threonyl-tRNA synthetase 1
  KO
K01868  threonyl-tRNA synthetase [EC:6.1.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00866  Trichothiodystrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    6897 (TARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    6897 (TARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    6897 (TARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.3  threonine---tRNA ligase
     6897 (TARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (C/G)
   6897 (TARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    6897 (TARS1)
 Prokaryotic type
    6897 (TARS1)
SSDB
Motif
Pfam: tRNA-synt_2b HGTP_anticodon TGS tRNA_SAD
Other DBs
NCBI-GeneID: 6897
NCBI-ProteinID: NP_001245366
OMIM: 187790
HGNC: 11572
Ensembl: ENSG00000113407
UniProt: P26639
Structure
Position
5:33440696..33468091
AA seq 723 aa
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF
NT seq 2172 nt   +upstreamnt  +downstreamnt
atgtttgaggagaaggccagcagtccttcagggaagatgggaggcgaggagaagccgatt
ggtgctggtgaagagaagcaaaaggaaggaggcaaaaagaagaacaaagaaggatctgga
gatggaggtcgagctgagttgaatccttggcctgaatatatttacacacgtcttgagatg
tataatatactaaaagcagaacatgattccattctggcagaaaaggcagaaaaagatagc
aagccaattaaagtcactttgcctgatggtaaacaggttgatgcggaatcttggaaaact
acaccatatcaaattgcctgtggaattagtcaaggcctggccgacaacaccgttattgct
aaagtaaataatgttgtgtgggacctggaccgccctctggaagaagattgtaccttggag
cttctcaagtttgaggatgaggaagctcaggcagtgtattggcactctagtgctcacata
atgggtgaagccatggaaagagtctatggtggatgtttatgctacggtccgccaatagaa
aatggattctattatgacatgtacctcgaagaagggggtgtgtctagcaatgatttctct
tctctggaggctttgtgtaagaaaatcattaaagaaaaacaagcttttgaaagactggaa
gttaagaaagaaactttactggcaatgtttaagtacaacaagttcaaatgccggatattg
aatgaaaaggtgaatactccaactaccacagtctatagatgtggccctttgatagatctc
tgccggggtcctcatgttagacacacgggcaaaattaaggctttaaaaatacacaaaaat
tcctccacgtactgggaaggcaaagcagatatggagactctccagagaatttatggcatt
tcattcccagatcctaaaatgttgaaagagtgggagaagttccaagaggaagctaaaaac
cgagatcataggaaaattggcagggaccaagaactatatttctttcatgaactcagccct
ggaagttgcttttttctgccaaaaggagcctacatttataatgcacttattgaattcatt
aggagcgaatataggaaaagaggattccaggaggtagtcaccccaaacatcttcaacagc
cgactctggatgacctcgggccactggcagcactacagcgagaacatgttctcctttgag
gtggagaaggagctgtttgccctgaaacccatgaactgcccaggacactgccttatgttt
gatcatcggccaaggtcctggcgagaactgcctctgcggctagctgattttggggtactt
cataggaacgagctgtctggagcactcacaggactcacccgggtacgaagattccaacag
gatgatgctcacatattctgtgccatggagcagattgaagatgaaataaaaggttgtttg
gattttctacgtacggtatatagcgtatttggattttcttttaaactaaacctttctact
cgcccggaaaaattccttggagatatcgaagtatgggatcaagctgagaaacaacttgaa
aacagtctgaatgaatttggtgaaaagtgggagttaaactctggagatggagctttctat
ggcccaaagattgacatacagattaaagatgcgattgggcggtaccaccagtgtgcaacc
atccagctggatttccagttgcccatcagatttaatcttacttatgtaagccatgatggt
gatgataagaaaaggccagtgattgttcatcgagccatcttgggatcagtggaaagaatg
attgctatcctcacagaaaactatgggggcaaatggcccttttggctgtcccctcgccag
gtaatggtagttccagtgggaccaacctgtgatgaatatgcccaaaaggtacgacaacaa
ttccacgatgccaaattcatggcagacattgatctggatccaggctgtacattgaataaa
aagattcgaaatgcacagttagcacagtataacttcattttagttgttggtgaaaaagag
aaaatcagtggcactgttaatatccgcacaagagacaataaggtccacggggaacgcacc
atttctgaaactatcgagcggctacagcagctcaaagagttccgcagcaaacaggcagaa
gaagaattttaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (38)   
   RefSeq(nuc) (6)   
   GenBank (16)   
   EMBL (16)   
3D Structure (5)   
   PDB (5)   
Protein domain (4)   
   Pfam (4)   
All databases (89)   

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