KEGG   Homo sapiens (human): 6916
Entry
6916              CDS       T01001                                 
Symbol
TBXAS1, BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
Name
(RefSeq) thromboxane A synthase 1
  KO
K01832  thromboxane-A synthase [EC:5.3.99.5]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa01100  Metabolic pathways
hsa04611  Platelet activation
Disease
H00490  Diaphyseal dysplasia with anemia
Drug target
Dazmegrel: D03661
Dazoxiben hydrochloride: D03663
Furegrelate sodium: D04276
Ozagrel (DG01256): D01683<JP> D01684<JP> D08327
Picotamide: D07140
Pirmagrel: D05502
Ridogrel: D05727
Terbogrel: D06077
Trapidil: D01220<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    6916 (TBXAS1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    6916 (TBXAS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    6916 (TBXAS1)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.99  Other intramolecular oxidoreductases
    5.3.99.5  thromboxane-A synthase
     6916 (TBXAS1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP5 family
   6916 (TBXAS1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 6916
NCBI-ProteinID: NP_001052
OMIM: 274180
HGNC: 11609
Ensembl: ENSG00000059377
UniProt: P24557 Q53F23
Position
7:139778242..140020293
AA seq 533 aa
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
NT seq 1602 nt   +upstreamnt  +downstreamnt
atggaagccttggggtttctaaaattggaagtgaatggccccatggtgacggtggccctg
tcagtggctctcttggccctcctgaaatggtactccacatcagcattctcaagactggag
aagttaggcctcagacatcccaagccttctcctttcattggaaacttgacatttttccgc
cagggtttttgggaaagccaaatggagctcagaaagctgtatggacctctgtgtgggtac
tatcttggtcgtcggatgtttattgttatttctgagccagacatgatcaagcaggtgttg
gttgagaacttcagtaactttaccaacagaatggcgtcgggtttggagttcaagtcggta
gccgacagcgttctgtttttacgtgacaaaagatgggaagaggtcagaggtgccctgatg
tctgctttcagtcctgaaaagctgaacgagatggttcccctcatcagccaagcctgcgac
cttctcctggctcatttaaaacgctatgcggaatctggggacgcatttgacatccagagg
tgctactgcaattacaccacagatgtggttgccagcgtcgcctttggcaccccggtggac
tcctggcaggcccctgaggatccctttgtgaaacactgcaagcgtttcttcgaattctgc
atccccagacctatcctggttttactcttatcatttccatccataatggtcccactggcc
cggattttgcccaataagaaccgagacgaactgaatggcttttttaacaaactcattagg
aatgtgattgccttgcgggaccagcaagctgccgaagagaggcggagagacttcctccaa
atggtcctggatgcccgacattctgcaagtcccatgggcgtgcaagactttgacatcgtc
agagacgttttctcctctactgggtgcaagccgaacccttcccggcaacaccagcccagc
cctatggccaggcctttgactgtggatgagattgtgggccaggccttcatcttcctcatc
gctggctatgaaatcatcaccaacacactttcttttgccacctacctactggccaccaac
cctgactgccaagagaagcttctgagagaggtagacgtttttaaggagaaacacatggcc
cctgagttctgcagcctcgaggaaggcctgccctatctggacatggtgattgcagagacg
ctgaggatgtacccgccagctttcagattcacacgggaggcagctcaggactgcgaggtg
ctggggcagcgcatccccgcaggcgctgtgctagagatggccgtgggtgccctgcaccat
gaccctgagcactggccaagcccggagaccttcaaccctgaaaggttcacggctgaggcc
cggcagcagcaccggcccttcacgtacctgcccttcggggccggcccacggagctgcctc
ggggtgcgtctagggctgcttgaggtcaagttgacactgctccacgtgctgcacaagttc
cggttccaagcctgccctgagacccaggtaccgctgcagctagaatccaaatctgcccta
ggtccaaaaaatggtgtctatatcaagatcgtatcccgctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (11)   
   KEGG DRUG (11)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (13)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (45)   
   RefSeq(nuc) (13)   
   GenBank (16)   
   EMBL (16)   
Protein domain (1)   
   Pfam (1)   
All databases (103)   

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