KEGG   Homo sapiens (human): 6929
Entry
6929              CDS       T01001                                 
Symbol
TCF3, AGM8, AGM8A, AGM8B, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21, p75
Name
(RefSeq) transcription factor 3
  KO
K09063  transcription factor E2-alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa05166  Human T-cell leukemia virus 1 infection
hsa05202  Transcriptional misregulation in cancer
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06240  Transcription (cancer)
  Element
N00117  E2A-PBX1 fusion to transcriptional activation
N00121  LMO2-rearrangement to transcriptional activation
N00122  LMO2-rearrangement to transcriptional repression
N00511  HTLV-1 Tax to E47-mediated transcription
Disease
H00001  B-cell acute lymphoblastic leukemia
H00085  Agammaglobulinemias
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    6929 (TCF3)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    6929 (TCF3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    6929 (TCF3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    6929 (TCF3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Ubiquitous (class A) factors
    6929 (TCF3)
SSDB
Motif
Pfam: HLH Response_reg_2
Other DBs
NCBI-GeneID: 6929
NCBI-ProteinID: NP_003191
OMIM: 147141
HGNC: 11633
Ensembl: ENSG00000071564
UniProt: P15923
Structure
Position
19:complement(1609292..1652615)
AA seq 654 aa
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWG
SGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGKSGERGAYASFGRDAGVGGL
TQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPML
GGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGAT
YGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLP
GHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPD
SYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPP
EQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQAVSVIL
NLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM
NT seq 1965 nt   +upstreamnt  +downstreamnt
atgaaccagccgcagaggatggcgcctgtgggcacagacaaggagctcagtgacctcctg
gacttcagcatgatgttcccgctgcctgtcaccaacgggaagggccggcccgcctccctg
gccggggcgcagttcggaggttcaggtcttgaggaccggcccagctcaggctcctggggc
agcggcgaccagagcagctcctcctttgaccccagccggaccttcagcgagggcacccac
ttcactgagtcgcacagcagcctctcttcatccacattcctgggaccgggactcggaggc
aagagcggtgagcggggcgcctatgcctccttcgggagagacgcaggcgtgggcggcctg
actcaggctggcttcctgtcaggcgagctggccctcaacagccccgggcccctgtcccct
tcgggcatgaaggggacctcccagtactacccctcctactccggcagctcccggcggaga
gcggcagacggcagcctagacacgcagcccaagaaggtccggaaggtcccgccgggtctt
ccatcctcggtgtacccacccagctcaggtgaggactacggcagggatgccaccgcctac
ccgtccgccaagacccccagcagcacctatcccgcccccttctacgtggcagatggcagc
ctgcacccctcagccgagctctggagtcccccgggccaggcgggcttcgggcccatgctg
ggtgggggctcatccccgctgcccctcccgcccggtagcggcccggtgggcagcagtgga
agcagcagcacgtttggtggcctgcaccagcacgagcgtatgggctaccagctgcatgga
gcagaggtgaacggtgggctcccatctgcatcctccttctcctcagcccccggagccacg
tacggcggcgtctccagccacacgccgcctgtcagcggggccgacagcctcctgggctcc
cgagggaccacagctggcagctccggggatgccctcggcaaagcactggcctcgatctac
tccccggatcactcaagcaataacttctcgtccagcccttctacccccgtgggctccccc
cagggcctggcaggaacgtcacagtggcctcgagcaggagcccccggtgccttatcgccc
agctacgacgggggtctccacggcctgcagagtaagatagaagaccacctggacgaggcc
atccacgtgctccgcagccacgccgtgggcacagccggcgacatgcacacgctgctgcct
ggccacggggcgctggcctcaggtttcaccggccccatgtcactgggcgggcggcacgca
ggcctggttggaggcagccaccccgaggacggcctcgcaggcagcaccagcctcatgcac
aaccacgcggccctccccagccagccaggcaccctccctgacctgtctcggcctcccgac
tcctacagtgggctagggcgagcaggtgccacggcggccgccagcgagatcaagcgggag
gagaaggaggacgaggagaacacgtcagcggctgaccactcggaggaggagaagaaggag
ctgaaggccccccgggcccggaccagcccagacgaggacgaggacgaccttctcccccca
gagcagaaggccgagcgggagaaggagcgccgggtggccaataacgcccgggagcggctg
cgggtccgtgacatcaacgaggcctttaaggagctggggcgcatgtgccaactgcacctc
aacagcgagaagccccagaccaaactgctcatcctgcaccaggctgtctcggtcatcctg
aacttggagcagcaagtgcgagagcggaacctgaatcccaaagcagcctgtttgaaacgg
cgagaagaggaaaaggtgtcaggtgtggttggagacccccagatggtgctttcagctccc
cacccaggcctgagcgaagcccacaaccccgccgggcacatgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (6)   
   KEGG NETWORK (6)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (98)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (96)   
DNA sequence (140)   
   RefSeq(nuc) (96)   
   GenBank (22)   
   EMBL (22)   
3D Structure (5)   
   PDB (5)   
Protein domain (2)   
   Pfam (2)   
All databases (281)   

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