KEGG   Homo sapiens (human): 6999
Entry
6999              CDS       T01001                                 
Symbol
TDO2, HYPTRP, TDO, TO, TPH2, TRPO
Name
(RefSeq) tryptophan 2,3-dioxygenase
  KO
K00453  tryptophan 2,3-dioxygenase [EC:1.13.11.11]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
Disease
H02545  Hypertryptophanemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    6999 (TDO2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.11  tryptophan 2,3-dioxygenase
     6999 (TDO2)
SSDB
Motif
Pfam: Trp_dioxygenase DUF3107
Other DBs
NCBI-GeneID: 6999
NCBI-ProteinID: NP_005642
OMIM: 191070
HGNC: 11708
Ensembl: ENSG00000151790
UniProt: P48775
Structure
Position
4:155903696..155920406
AA seq 406 aa
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
NT seq 1221 nt   +upstreamnt  +downstreamnt
atgagtgggtgcccatttttaggaaacaactttggatatacttttaaaaaactccccgta
gaaggcagcgaagaagacaaatcacaaactggtgtgaatagagccagcaaaggaggtctt
atctatgggaactacctgcatttggaaaaagttttgaatgcacaagaactgcaaagtgaa
acaaaaggaaataaaatccatgatgaacatctttttatcataactcatcaagcttatgaa
ctctggtttaagcaaatcctctgggagttggattctgttcgagagatctttcagaatggc
catgtcagagatgaaaggaacatgcttaaggttgtttctcggatgcaccgagtgtcagtg
atcctgaaactgctggtgcagcagttttccattctggagacgatgacagccttggacttc
aatgacttcagagagtacttatctccagcatcaggcttccagagtttgcaattccgacta
ttagaaaacaagataggtgttcttcagaacatgagagtcccttataacagaagacattat
cgtgataacttcaaaggagaagaaaatgaactgctacttaaatctgagcaggaaaagaca
cttctggaattagtggaggcatggctggaaagaactccaggtttagagccacatggattt
aacttctggggaaagcttgaaaaaaatatcaccagaggcctggaagaggaattcataagg
attcaggctaaagaagagtctgaagaaaaagaggaacaggtggctgaatttcagaagcaa
aaagaggtgctactgtccttatttgatgagaaacgtcatgaacatctccttagtaaaggt
gaaagacggctgtcatacagagcacttcagggagcattgatgatatatttttacagggaa
gagcctaggttccaggtgccttttcagttgctgacttctcttatggacatagattcactg
atgaccaaatggagatataaccatgtgtgcatggtgcacagaatgctgggcagcaaagct
ggcaccggtggttcctcaggctatcactacctgcgatcaactgtgagtgataggtacaag
gtatttgtagatttatttaatctttcaacatacctgattccccgacactggataccgaag
atgaacccaaccattcacaaatttctatatacagcagaatactgtgatagctcctacttc
agcagtgatgaatcagattaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (9)   
   PDB (9)   
Protein domain (2)   
   Pfam (2)   
All databases (59)   

Download RDF
DBGET integrated database retrieval system