KEGG   Homo sapiens (human): 7037
Entry
7037              CDS       T01001                                 
Symbol
TFRC, CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90
Name
(RefSeq) transferrin receptor
  KO
K06503  transferrin receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa04144  Endocytosis
hsa04145  Phagosome
hsa04216  Ferroptosis
hsa04350  TGF-beta signaling pathway
hsa04640  Hematopoietic cell lineage
Network
nt06525  Ferroptosis
  Element
N01587  Fe-TF transport
Disease
H02526  Disorders of adaptive immunity
Drug target
Pabinafusp alfa: D11812<JP>
Tividenofusp alfa: D12806
Trontinemab: D12509
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    7037 (TFRC)
   04066 HIF-1 signaling pathway
    7037 (TFRC)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    7037 (TFRC)
   04145 Phagosome
    7037 (TFRC)
  09143 Cell growth and death
   04216 Ferroptosis
    7037 (TFRC)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    7037 (TFRC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7037 (TFRC)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    7037 (TFRC)
   04090 CD molecules [BR:hsa04090]
    7037 (TFRC)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M28: aminopeptidase Y family
   7037 (TFRC)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   7037 (TFRC)
  Exosomal proteins of colorectal cancer cells
   7037 (TFRC)
CD molecules [BR:hsa04090]
 Proteins
  7037 (TFRC)
SSDB
Motif
Pfam: Peptidase_M28 TFR_dimer PA DUF3855
Other DBs
NCBI-GeneID: 7037
NCBI-ProteinID: NP_001121620
OMIM: 190010
HGNC: 11763
Ensembl: ENSG00000072274
UniProt: P02786 Q7Z3E0
Structure
Position
3:complement(196049284..196082090)
AA seq 760 aa
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK
RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR
RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK
VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK
KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH
AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD
STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG
VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT
YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA
AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK
LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF
GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK
QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
NT seq 2283 nt   +upstreamnt  +downstreamnt
atgatggatcaagctagatcagcattctctaacttgtttggtggagaaccattgtcatat
acccggttcagcctggctcggcaagtagatggcgataacagtcatgtggagatgaaactt
gctgtagatgaagaagaaaatgctgacaataacacaaaggccaatgtcacaaaaccaaaa
aggtgtagtggaagtatctgctatgggactattgctgtgatcgtctttttcttgattgga
tttatgattggctacttgggctattgtaaaggggtagaaccaaaaactgagtgtgagaga
ctggcaggaaccgagtctccagtgagggaggagccaggagaggacttccctgcagcacgt
cgcttatattgggatgacctgaagagaaagttgtcggagaaactggacagcacagacttc
accggcaccatcaagctgctgaatgaaaattcatatgtccctcgtgaggctggatctcaa
aaagatgaaaatcttgcgttgtatgttgaaaatcaatttcgtgaatttaaactcagcaaa
gtctggcgtgatcaacattttgttaagattcaggtcaaagacagcgctcaaaactcggtg
atcatagttgataagaacggtagacttgtttacctggtggagaatcctgggggttatgtg
gcgtatagtaaggctgcaacagttactggtaaactggtccatgctaattttggtactaaa
aaagattttgaggatttatacactcctgtgaatggatctatagtgattgtcagagcaggg
aaaatcacctttgcagaaaaggttgcaaatgctgaaagcttaaatgcaattggtgtgttg
atatacatggaccagactaaatttcccattgttaacgcagaactttcattctttggacat
gctcatctggggacaggtgacccttacacacctggattcccttccttcaatcacactcag
tttccaccatctcggtcatcaggattgcctaatatacctgtccagacaatctccagagct
gctgcagaaaagctgtttgggaatatggaaggagactgtccctctgactggaaaacagac
tctacatgtaggatggtaacctcagaaagcaagaatgtgaagctcactgtgagcaatgtg
ctgaaagagataaaaattcttaacatctttggagttattaaaggctttgtagaaccagat
cactatgttgtagttggggcccagagagatgcatggggccctggagctgcaaaatccggt
gtaggcacagctctcctattgaaacttgcccagatgttctcagatatggtcttaaaagat
gggtttcagcccagcagaagcattatctttgccagttggagtgctggagactttggatcg
gttggtgccactgaatggctagagggatacctttcgtccctgcatttaaaggctttcact
tatattaatctggataaagcggttcttggtaccagcaacttcaaggtttctgccagccca
ctgttgtatacgcttattgagaaaacaatgcaaaatgtgaagcatccggttactgggcaa
tttctatatcaggacagcaactgggccagcaaagttgagaaactcactttagacaatgct
gctttccctttccttgcatattctggaatcccagcagtttctttctgtttttgcgaggac
acagattatccttatttgggtaccaccatggacacctataaggaactgattgagaggatt
cctgagttgaacaaagtggcacgagcagctgcagaggtcgctggtcagttcgtgattaaa
ctaacccatgatgttgaattgaacctggactatgagaggtacaacagccaactgctttca
tttgtgagggatctgaaccaatacagagcagacataaaggaaatgggcctgagtttacag
tggctgtattctgctcgtggagacttcttccgtgctacttccagactaacaacagatttc
gggaatgctgagaaaacagacagatttgtcatgaagaaactcaatgatcgtgtcatgaga
gtggagtatcacttcctctctccctacgtatctccaaaagagtctcctttccgacatgtc
ttctggggctccggctctcacacgctgccagctttactggagaacttgaaactgcgtaaa
caaaataacggtgcttttaatgaaacgctgttcagaaaccagttggctctagctacttgg
actattcagggagctgcaaatgccctctctggtgacgtttgggacattgacaatgagttt
taa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (6)   
   KEGG PATHWAY (6)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
   PROTHERM (2)   
Protein sequence (13)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (41)   
   RefSeq(nuc) (17)   
   GenBank (12)   
   EMBL (12)   
3D Structure (21)   
   PDB (21)   
Protein domain (4)   
   Pfam (4)   
All databases (116)   

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