KEGG   Homo sapiens (human): 7043
Entry
7043              CDS       T01001                                 
Symbol
TGFB3, ARVD, ARVD1, LDS5, RNHF, TGF-beta3
Name
(RefSeq) transforming growth factor beta 3
  KO
K13377  transforming growth factor beta-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04068  FoxO signaling pathway
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04350  TGF-beta signaling pathway
hsa04390  Hippo signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05140  Leishmaniasis
hsa05142  Chagas disease
hsa05144  Malaria
hsa05145  Toxoplasmosis
hsa05146  Amoebiasis
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05166  Human T-cell leukemia virus 1 infection
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05220  Chronic myeloid leukemia
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05321  Inflammatory bowel disease
hsa05323  Rheumatoid arthritis
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05415  Diabetic cardiomyopathy
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06218  TGFB signaling (cancer)
nt06225  HIF-1 signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06276  Chronic myeloid leukemia
nt06507  TGFB signaling
  Element
N00063  TGF-beta signaling pathway
N00079  HIF-1 signaling pathway
N00080  Loss of VHL to HIF-1 signaling pathway
N00081  Mutation-inactivated VHL to HIF-1 signaling pathway
N00531  HBV HBx to TGF-beta signaling pathway
N01460  Plasmin mediated activation of latent TGF-beta
Disease
H00083  Allograft rejection
H00084  Graft-versus-host disease
H00293  Arrhythmogenic right ventricular cardiomyopathy
H00431  Ossification of the posterior longitudinal ligament of spine
H00800  Loeys-Dietz syndrome
H01385  Rienhoff syndrome
Drug target
Fresolimumab: D09620
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7043 (TGFB3)
   04350 TGF-beta signaling pathway
    7043 (TGFB3)
   04390 Hippo signaling pathway
    7043 (TGFB3)
   04068 FoxO signaling pathway
    7043 (TGFB3)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    7043 (TGFB3)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    7043 (TGFB3)
   04218 Cellular senescence
    7043 (TGFB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7043 (TGFB3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    7043 (TGFB3)
   05212 Pancreatic cancer
    7043 (TGFB3)
   05225 Hepatocellular carcinoma
    7043 (TGFB3)
   05226 Gastric cancer
    7043 (TGFB3)
   05220 Chronic myeloid leukemia
    7043 (TGFB3)
   05211 Renal cell carcinoma
    7043 (TGFB3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7043 (TGFB3)
   05161 Hepatitis B
    7043 (TGFB3)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    7043 (TGFB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    7043 (TGFB3)
   05144 Malaria
    7043 (TGFB3)
   05145 Toxoplasmosis
    7043 (TGFB3)
   05140 Leishmaniasis
    7043 (TGFB3)
   05142 Chagas disease
    7043 (TGFB3)
  09163 Immune disease
   05323 Rheumatoid arthritis
    7043 (TGFB3)
   05321 Inflammatory bowel disease
    7043 (TGFB3)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    7043 (TGFB3)
   05414 Dilated cardiomyopathy
    7043 (TGFB3)
   05415 Diabetic cardiomyopathy
    7043 (TGFB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    7043 (TGFB3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    7043 (TGFB3)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Transforming growth factors (RSTK binding)
   7043 (TGFB3)
SSDB
Motif
Pfam: TGFb_propeptide TGF_beta
Other DBs
NCBI-GeneID: 7043
NCBI-ProteinID: NP_001316868
OMIM: 190230
HGNC: 11769
Ensembl: ENSG00000119699
UniProt: P10600 A5YM40
Structure
Position
14:complement(75958097..75983011)
AA seq 412 aa
MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT
VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL
AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI
AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE
NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST
VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
NT seq 1239 nt   +upstreamnt  +downstreamnt
atgaagatgcacttgcaaagggctctggtggtcctggccctgctgaactttgccacggtc
agcctctctctgtccacttgcaccaccttggacttcggccacatcaagaagaagagggtg
gaagccattaggggacagatcttgagcaagctcaggctcaccagcccccctgagccaacg
gtgatgacccacgtcccctatcaggtcctggccctttacaacagcacccgggagctgctg
gaggagatgcatggggagagggaggaaggctgcacccaggaaaacaccgagtcggaatac
tatgccaaagaaatccataaattcgacatgatccaggggctggcggagcacaacgaactg
gctgtctgccctaaaggaattacctccaaggttttccgcttcaatgtgtcctcagtggag
aaaaatagaaccaacctattccgagcagaattccgggtcttgcgggtgcccaaccccagc
tctaagcggaatgagcagaggatcgagctcttccagatccttcggccagatgagcacatt
gccaaacagcgctatatcggtggcaagaatctgcccacacggggcactgccgagtggctg
tcctttgatgtcactgacactgtgcgtgagtggctgttgagaagagagtccaacttaggt
ctagaaatcagcattcactgtccatgtcacacctttcagcccaatggagatatcctggaa
aacattcacgaggtgatggaaatcaaattcaaaggcgtggacaatgaggatgaccatggc
cgtggagatctggggcgcctcaagaagcagaaggatcaccacaaccctcatctaatcctc
atgatgattcccccacaccggctcgacaacccgggccaggggggtcagaggaagaagcgg
gctttggacaccaattactgcttccgcaacttggaggagaactgctgtgtgcgccccctc
tacattgacttccgacaggatctgggctggaagtgggtccatgaacctaagggctactat
gccaacttctgctcaggcccttgcccatacctccgcagtgcagacacaacccacagcacg
gtgctgggactgtacaacactctgaaccctgaagcatctgcctcgccttgctgcgtgccc
caggacctggagcccctgaccatcctgtactatgttgggaggacccccaaagtggagcag
ctctccaacatggtggtgaagtcttgtaaatgtagctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (28)   
   KEGG PATHWAY (28)   
Network (16)   
   KEGG NETWORK (16)   
Disease (9)   
   KEGG DISEASE (6)   
   OMIM (3)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (29)   
   RefSeq(nuc) (3)   
   GenBank (13)   
   EMBL (13)   
3D Structure (6)   
   PDB (6)   
Protein domain (2)   
   Pfam (2)   
All databases (110)   

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