KEGG T01001: 7046

Homo sapiens (human): 7046

Entry

7046              CDS       T01001

Symbol

TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TBR-i, TBRI, TGFR-1, tbetaR-I

Name

(RefSeq) transforming growth factor beta receptor 1

K04674

TGF-beta receptor type-1 [EC:2.7.11.30]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04068

FoxO signaling pathway

hsa04144

Endocytosis

hsa04218

Cellular senescence

hsa04350

TGF-beta signaling pathway

hsa04371

Apelin signaling pathway

hsa04380

Osteoclast differentiation

hsa04390

Hippo signaling pathway

hsa04520

Adherens junction

hsa04659

Th17 cell differentiation

hsa04926

Relaxin signaling pathway

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa05142

Chagas disease

hsa05161

Hepatitis B

hsa05166

Human T-cell leukemia virus 1 infection

hsa05200

Pathways in cancer

hsa05210

Colorectal cancer

hsa05212

Pancreatic cancer

hsa05220

Chronic myeloid leukemia

hsa05225

Hepatocellular carcinoma

hsa05226

Gastric cancer

hsa05415

Diabetic cardiomyopathy

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06218  TGFB signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06276  Chronic myeloid leukemia
nt06507  TGFB signaling

Element

N00063

TGF-beta signaling pathway

N00064

Mutation-inactivated TGFBR2 to TGF-beta signaling pathway

N00065

Mutation-inactivated SMAD2 to TGF-beta signaling pathway

N00241

TGFBR2-reduced expression to TGF-beta signaling pathway

N00256

TGFBR1-reduced expression to TGF-beta signaling pathway

N00531

HBV HBx to TGF-beta signaling pathway

N01457

Myostatin signaling pathway

Disease

H00018

Gastric cancer

H00800

Loeys-Dietz syndrome

H00801

Familial thoracic aortic aneurysm and dissection

Drug target

Galunisertib:

D10437

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    7046 (TGFBR1)
   04350 TGF-beta signaling pathway
    7046 (TGFBR1)
   04390 Hippo signaling pathway
    7046 (TGFBR1)
   04371 Apelin signaling pathway
    7046 (TGFBR1)
   04068 FoxO signaling pathway
    7046 (TGFBR1)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    7046 (TGFBR1)
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    7046 (TGFBR1)
  09143 Cell growth and death
   04218 Cellular senescence
    7046 (TGFBR1)
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    7046 (TGFBR1)
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    7046 (TGFBR1)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    7046 (TGFBR1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    7046 (TGFBR1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7046 (TGFBR1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    7046 (TGFBR1)
   05212 Pancreatic cancer
    7046 (TGFBR1)
   05225 Hepatocellular carcinoma
    7046 (TGFBR1)
   05226 Gastric cancer
    7046 (TGFBR1)
   05220 Chronic myeloid leukemia
    7046 (TGFBR1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    7046 (TGFBR1)
   05161 Hepatitis B
    7046 (TGFBR1)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    7046 (TGFBR1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    7046 (TGFBR1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    7046 (TGFBR1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7046 (TGFBR1)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     7046 (TGFBR1)
Protein kinases [BR:hsa01001]
Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   7046 (TGFBR1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr TGF_beta_GS Activin_recp Pkinase_fungal APH Haspin_kinase FTA2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

9:99103647..99154192

AA seq 503 aa
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM

NT seq 1512 nt +upstreamnt +downstreamnt
atggaggcggcggtcgctgctccgcgtccccggctgctcctcctcgtgctggcggcggcg
gcggcggcggcggcggcgctgctcccgggggcgacggcgttacagtgtttctgccacctc
tgtacaaaagacaattttacttgtgtgacagatgggctctgctttgtctctgtcacagag
accacagacaaagttatacacaacagcatgtgtatagctgaaattgacttaattcctcga
gataggccgtttgtatgtgcaccctcttcaaaaactgggtctgtgactacaacatattgc
tgcaatcaggaccattgcaataaaatagaacttccaactactgtaaagtcatcacctggc
cttggtcctgtggaactggcagctgtcattgctggaccagtgtgcttcgtctgcatctca
ctcatgttgatggtctatatctgccacaaccgcactgtcattcaccatcgagtgccaaat
gaagaggacccttcattagatcgcccttttatttcagagggtactacgttgaaagactta
atttatgatatgacaacgtcaggttctggctcaggtttaccattgcttgttcagagaaca
attgcgagaactattgtgttacaagaaagcattggcaaaggtcgatttggagaagtttgg
agaggaaagtggcggggagaagaagttgctgttaagatattctcctctagagaagaacgt
tcgtggttccgtgaggcagagatttatcaaactgtaatgttacgtcatgaaaacatcctg
ggatttatagcagcagacaataaagacaatggtacttggactcagctctggttggtgtca
gattatcatgagcatggatccctttttgattacttaaacagatacacagttactgtggaa
ggaatgataaaacttgctctgtccacggcgagcggtcttgcccatcttcacatggagatt
gttggtacccaaggaaagccagccattgctcatagagatttgaaatcaaagaatatcttg
gtaaagaagaatggaacttgctgtattgcagacttaggactggcagtaagacatgattca
gccacagataccattgatattgctccaaaccacagagtgggaacaaaaaggtacatggcc
cctgaagttctcgatgattccataaatatgaaacattttgaatccttcaaacgtgctgac
atctatgcaatgggcttagtattctgggaaattgctcgacgatgttccattggtggaatt
catgaagattaccaactgccttattatgatcttgtaccttctgacccatcagttgaagaa
atgagaaaagttgtttgtgaacagaagttaaggccaaatatcccaaacagatggcagagc
tgtgaagccttgagagtaatggctaaaattatgagagaatgttggtatgccaatggagca
gctaggcttacagcattgcggattaagaaaacattatcgcaactcagtcaacaggaaggc
atcaaaatgtaa

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