KEGG   Homo sapiens (human): 7086
Entry
7086              CDS       T01001                                 
Symbol
TKT, HEL-S-48, HEL107, SDDHD, TK, TKT1
Name
(RefSeq) transketolase
  KO
K00615  transketolase [EC:2.2.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00030  Pentose phosphate pathway
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
Module
hsa_M00004  Pentose phosphate pathway (Pentose phosphate cycle)
hsa_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P
Disease
H02439  Short stature, developmental delay, congenital heart defect
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    7086 (TKT)
  09109 Metabolism of terpenoids and polyketides
   01051 Biosynthesis of ansamycins
    7086 (TKT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.1  transketolase
     7086 (TKT)
SSDB
Motif
Pfam: Transket_pyr Transketolase_N Transketolase_C E1_dh DXP_synthase_N TPP_enzyme_C XFP_N Alba
Other DBs
NCBI-GeneID: 7086
NCBI-ProteinID: NP_001055
OMIM: 606781
HGNC: 11834
Ensembl: ENSG00000163931
UniProt: P29401 V9HWD9
Structure
Position
3:complement(53224712..53256022)
AA seq 623 aa
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA
NT seq 1872 nt   +upstreamnt  +downstreamnt
atggagagctaccacaagcctgaccagcagaagctgcaggccttgaaggacacggccaac
cgcctacgtatcagctccatccaggccaccactgcggcgggctctggccaccccacgtca
tgctgcagcgccgcagagatcatggctgtcctctttttccacaccatgcgctacaagtcc
caggacccccggaatccgcacaatgaccgctttgtgctctccaagggccatgcagctccc
atcctctacgcggtctgggctgaagctggtttcctggccgaggcggagctgctgaacctg
aggaagatcagctccgacttggacgggcacccggtcccgaaacaagctttcaccgacgtg
gccactggctccctgggccagggcctcggggccgcttgtgggatggcctacaccggcaaa
tacttcgacaaggccagctaccgagtctattgcttgctgggagacggggagctgtcagag
ggctctgtatgggaggccatggccttcgccagcatctataagctggacaaccttgtggcc
attctagacatcaatcgcctgggccagagtgacccggccccactgcagcaccagatggac
atctaccagaagcggtgcgaggccttcggttggcatgccatcatcgtggatggacacagc
gtggaggagctgtgcaaggcctttggccaggccaagcaccagccaacagccatcattgcc
aagaccttcaagggccgagggatcacgggggtagaagataaggagtcttggcatgggaag
cccctccccaaaaacatggctgagcagatcatccaggagatctacagccagatccagagc
aaaaagaagatcctggcaacccctccacaggaggacgcaccctcagtggacattgccaac
atccgcatgcccagcctgcccagctacaaagttggggacaagatagccacccgcaaggcc
tacgggcaggcactggccaagctgggccatgccagtgaccgcatcatcgccctggatggg
gacaccaaaaattccaccttctcggagatcttcaaaaaggagcacccggaccgcttcatc
gagtgctacattgctgagcagaacatggtgagcatcgcggtgggctgtgccacccgcaac
aggacggtgcccttctgcagcacttttgcagccttcttcacgcgggcctttgaccagatt
cgcatggccgccatctccgagagcaacatcaacctctgcggctcccactgcggcgtttcc
atcggggaagacgggccctcccagatggccctagaagatctggctatgtttcggtcagtc
cccacatcaactgtcttttacccaagtgatggcgttgctacagagaaggcagtggaacta
gccgccaatacaaagggtatctgcttcatccggaccagccgcccagaaaatgccatcatc
tataacaacaatgaggacttccaggtcggacaagccaaggtggtcctgaagagcaaggat
gaccaggtgaccgttatcggggctggggtgaccctgcacgaggccttggccgctgccgaa
ctgctgaagaaagaaaagatcaacatccgcgtgctggaccccttcaccatcaagcccctg
gacagaaaactcattctcgacagcgctcgtgccaccaagggcaggatcctcaccgtggag
gaccattattatgaaggtggcattggtgaggctgtgtccagtgcagtagtgggcgagcct
ggcatcactgtcacccacctggcagttaaccgggtaccaagaagtgggaagccggctgag
ctgctgaagatgtttggtatcgacagggatgccattgcacaagctgtgaggggcctcatc
accaaggcctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (4)   
   KEGG MODULE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (32)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (66)   
   RefSeq(nuc) (8)   
   GenBank (29)   
   EMBL (29)   
3D Structure (10)   
   PDB (10)   
Protein domain (8)   
   Pfam (8)   
All databases (165)   

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