KEGG   Homo sapiens (human): 7113
Entry
7113              CDS       T01001                                 
Symbol
TMPRSS2, PRSS10
Name
(RefSeq) transmembrane serine protease 2
  KO
K09633  transmembrane protease serine 2 [EC:3.4.21.122]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05164  Influenza A
hsa05171  Coronavirus disease - COVID-19
hsa05202  Transcriptional misregulation in cancer
hsa05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    7113 (TMPRSS2)
  09162 Cancer: specific types
   05215 Prostate cancer
    7113 (TMPRSS2)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    7113 (TMPRSS2)
   05164 Influenza A
    7113 (TMPRSS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7113 (TMPRSS2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.122  transmembrane protease serine 2
     7113 (TMPRSS2)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   7113 (TMPRSS2)
SSDB
Motif
Pfam: Trypsin SRCR_2 DUF1986 Hepsin-SRCR SRCR Trypsin_2 Ldl_recept_a
Other DBs
NCBI-GeneID: 7113
NCBI-ProteinID: NP_005647
OMIM: 602060
HGNC: 11876
Ensembl: ENSG00000184012
UniProt: O15393
Structure
Position
21:complement(41464305..41508158)
AA seq 492 aa
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
TDWIYRQMRADG
NT seq 1479 nt   +upstreamnt  +downstreamnt
atggctttgaactcagggtcaccaccagctattggaccttactatgaaaaccatggatac
caaccggaaaacccctatcccgcacagcccactgtggtccccactgtctacgaggtgcat
ccggctcagtactacccgtcccccgtgccccagtacgccccgagggtcctgacgcaggct
tccaaccccgtcgtctgcacgcagcccaaatccccatccgggacagtgtgcacctcaaag
actaagaaagcactgtgcatcaccttgaccctggggaccttcctcgtgggagctgcgctg
gccgctggcctactctggaagttcatgggcagcaagtgctccaactctgggatagagtgc
gactcctcaggtacctgcatcaacccctctaactggtgtgatggcgtgtcacactgcccc
ggcggggaggacgagaatcggtgtgttcgcctctacggaccaaacttcatccttcaggtg
tactcatctcagaggaagtcctggcaccctgtgtgccaagacgactggaacgagaactac
gggcgggcggcctgcagggacatgggctataagaataatttttactctagccaaggaata
gtggatgacagcggatccaccagctttatgaaactgaacacaagtgccggcaatgtcgat
atctataaaaaactgtaccacagtgatgcctgttcttcaaaagcagtggtttctttacgc
tgtatagcctgcggggtcaacttgaactcaagccgccagagcaggattgtgggcggcgag
agcgcgctcccgggggcctggccctggcaggtcagcctgcacgtccagaacgtccacgtg
tgcggaggctccatcatcacccccgagtggatcgtgacagccgcccactgcgtggaaaaa
cctcttaacaatccatggcattggacggcatttgcggggattttgagacaatctttcatg
ttctatggagccggataccaagtagaaaaagtgatttctcatccaaattatgactccaag
accaagaacaatgacattgcgctgatgaagctgcagaagcctctgactttcaacgaccta
gtgaaaccagtgtgtctgcccaacccaggcatgatgctgcagccagaacagctctgctgg
atttccgggtggggggccaccgaggagaaagggaagacctcagaagtgctgaacgctgcc
aaggtgcttctcattgagacacagagatgcaacagcagatatgtctatgacaacctgatc
acaccagccatgatctgtgccggcttcctgcaggggaacgtcgattcttgccagggtgac
agtggagggcctctggtcacttcgaagaacaatatctggtggctgataggggatacaagc
tggggttctggctgtgccaaagcttacagaccaggagtgtacgggaatgtgatggtattc
acggactggatttatcgacaaatgagggcagacggctaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (37)   
   RefSeq(nuc) (3)   
   GenBank (17)   
   EMBL (17)   
3D Structure (1)   
   PDB (1)   
Protein domain (7)   
   Pfam (7)   
All databases (85)   

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