KEGG   Homo sapiens (human): 7128
Entry
7128              CDS       T01001                                 
Symbol
TNFAIP3, A20, AIFBL1, AISBL, OTUD7C, TNFA1P2
Name
(RefSeq) TNF alpha induced protein 3
  KO
K11859  tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04217  Necroptosis
hsa04621  NOD-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04668  TNF signaling pathway
hsa05162  Measles
hsa05169  Epstein-Barr virus infection
Network
nt06169  Measles virus (MV)
nt06516  TNF signaling
nt06517  TLR signaling
  Element
N00692  MV P to TLR2/4-NFKB signaling pathway
N01546  Regulation of TNF-NFKB signaling pathway, OTULIN/TNFAIP3-mediated deubiquitination
Disease
H02424  Primary central nervous system lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
H02592  Familial Behcet-like autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    7128 (TNFAIP3)
   04668 TNF signaling pathway
    7128 (TNFAIP3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    7128 (TNFAIP3)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    7128 (TNFAIP3)
   04657 IL-17 signaling pathway
    7128 (TNFAIP3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    7128 (TNFAIP3)
   05169 Epstein-Barr virus infection
    7128 (TNFAIP3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7128 (TNFAIP3)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7128 (TNFAIP3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     7128 (TNFAIP3)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C64
   7128 (TNFAIP3)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   OTU
    7128 (TNFAIP3)
SSDB
Motif
Pfam: zf-A20 OTU
Other DBs
NCBI-GeneID: 7128
NCBI-ProteinID: NP_001257436
OMIM: 191163
HGNC: 11896
Ensembl: ENSG00000118503
UniProt: P21580
Structure
Position
6:137866349..137883312
AA seq 790 aa
MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRTCQFCPQF
REIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGNCLMHATSQYMWGVQDTDL
VLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTP
MARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPA
QECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKE
KLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENS
EQGRREGHAQNPMEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQKNQNKLPK
LNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGGPHSAPPTAPSPFLFSETTAMKCRS
PGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVTRTFNGICSTCF
KRTTAEASSSLSTSLPPSCHQRSKSDPSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGD
RTGTSKCRKAGCVYFGTPENKGFCTLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGR
ECGTLGSTMFEGYCQKCFIEAQNQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARAS
CKNILACRSEELCMECQHPNQRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCN
ECFQFKQMYG
NT seq 2373 nt   +upstreamnt  +downstreamnt
atggctgaacaagtccttcctcaggctttgtatttgagcaatatgcggaaagctgtgaag
atacgggagagaactccagaagacatttttaaacctactaatgggatcattcatcatttt
aaaaccatgcaccgatacacactggaaatgttcagaacttgccagttttgtcctcagttt
cgggagatcatccacaaagccctcatcgacagaaacatccaggccaccctggaaagccag
aagaaactcaactggtgtcgagaagtccggaagcttgtggcgctgaaaacgaacggtgac
ggcaattgcctcatgcatgccacttctcagtacatgtggggcgttcaggacacagacttg
gtactgaggaaggcgctgttcagcacgctcaaggaaacagacacacgcaactttaaattc
cgctggcaactggagtctctcaaatctcaggaatttgttgaaacggggctttgctatgat
actcggaactggaatgatgaatgggacaatcttatcaaaatggcttccacagacacaccc
atggcccgaagtggacttcagtacaactcactggaagaaatacacatatttgtcctttgc
aacatcctcagaaggccaatcattgtcatttcagacaaaatgctaagaagtttggaatca
ggttccaatttcgcccctttgaaagtgggtggaatttacttgcctctccactggcctgcc
caggaatgctacagataccccattgttctcggctatgacagccatcattttgtacccttg
gtgaccctgaaggacagtgggcctgaaatccgagctgttccacttgttaacagagaccgg
ggaagatttgaagacttaaaagttcactttttgacagatcctgaaaatgagatgaaggag
aagctcttaaaagagtacttaatggtgatagaaatccccgtccaaggctgggaccatggc
acaactcatctcatcaatgccgcaaagttggatgaagctaacttaccaaaagaaatcaat
ctggtagatgattactttgaacttgttcagcatgagtacaagaaatggcaggaaaacagc
gagcaggggaggagagaggggcacgcccagaatcccatggaaccttccgtgccccagctt
tctctcatggatgtaaaatgtgaaacgcccaactgccccttcttcatgtctgtgaacacc
cagcctttatgccatgagtgctcagagaggcggcaaaagaatcaaaacaaactcccaaag
ctgaactccaagccgggccctgaggggctccctggcatggcgctcggggcctctcgggga
gaagcctatgagcccttggcgtggaaccctgaggagtccactggggggcctcattcggcc
ccaccgacagcacccagcccttttctgttcagtgagaccactgccatgaagtgcaggagc
cccggctgccccttcacactgaatgtgcagcacaacggattttgtgaacgttgccacaac
gcccggcaacttcacgccagccacgccccagaccacacaaggcacttggatcccgggaag
tgccaagcctgcctccaggatgttaccaggacatttaatgggatctgcagtacttgcttc
aaaaggactacagcagaggcctcctccagcctcagcaccagcctccctccttcctgtcac
cagcgttccaagtcagatccctcgcggctcgtccggagcccctccccgcattcttgccac
agagctggaaacgacgcccctgctggctgcctgtctcaagctgcacggactcctggggac
aggacggggacgagcaagtgcagaaaagccggctgcgtgtattttgggactccagaaaac
aagggcttttgcacactgtgtttcatcgagtacagagaaaacaaacattttgctgctgcc
tcagggaaagtcagtcccacagcgtccaggttccagaacaccattccgtgcctggggagg
gaatgcggcacccttggaagcaccatgtttgaaggatactgccagaagtgtttcattgaa
gctcagaatcagagatttcatgaggccaaaaggacagaagagcaactgagatcgagccag
cgcagagatgtgcctcgaaccacacaaagcacctcaaggcccaagtgcgcccgggcctcc
tgcaagaacatcctggcctgccgcagcgaggagctctgcatggagtgtcagcatcccaac
cagaggatgggccctggggcccaccggggtgagcctgcccccgaagacccccccaagcag
cgttgccgggcccccgcctgtgatcattttggcaatgccaagtgcaacggctactgcaac
gaatgctttcagttcaagcagatgtatggctaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (5)   
   KEGG NETWORK (5)   
Disease (5)   
   KEGG DISEASE (3)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (77)   
   RefSeq(nuc) (19)   
   GenBank (29)   
   EMBL (29)   
3D Structure (17)   
   PDB (17)   
Protein domain (2)   
   Pfam (2)   
All databases (164)   

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