KEGG   Homo sapiens (human): 7204
Entry
7204              CDS       T01001                                 
Symbol
TRIO, ARHGEF23, MEBAS, MRD44, MRD63, tgat
Name
(RefSeq) trio Rho guanine nucleotide exchange factor
  KO
K08810  triple functional domain protein [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7204 (TRIO)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7204 (TRIO)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     7204 (TRIO)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  Trio family [OT]
   7204 (TRIO)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    7204 (TRIO)
SSDB
Motif
Pfam: SH3-RhoG_link RhoGEF Pkinase Spectrin PK_Tyr_Ser-Thr I-set PH Ig_3 SH3_1 ig CRAL_TRIO_2 SH3_2 PH_10 CRAL_TRIO SH3_9 Ig_2 IQ_SEC7_PH V-set PH_13
Other DBs
NCBI-GeneID: 7204
NCBI-ProteinID: NP_009049
OMIM: 601893
HGNC: 12303
Ensembl: ENSG00000038382
UniProt: O75962
Structure
Position
5:14143342..14510204
AA seq 3097 aa
MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM
KAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVC
KRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDI
LAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSG
NADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIR
QIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDL
EDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL
HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV
RRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKI
KLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNN
LTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKT
HQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS
EQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQY
VVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLI
QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW
EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF
QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTL
IRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVG
RTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRG
QTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVS
SNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEG
EEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSK
MALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED
PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKP
VQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA
QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV
SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL
TSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSR
IPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAE
GSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSP
LSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG
KDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQI
LASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRK
KSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGE
TVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCI
AVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKR
AVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDC
VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDA
VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET
CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV
LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV
NT seq 9294 nt   +upstreamnt  +downstreamnt
atgagcggcagcagcggcggagccgccgcccccgccgcgtcctccggccccgccgcggcg
gccagcgcggctggctcgggctgcgggggcggtgccggcgagggggcagaggaggcggcc
aaggacctggccgacatcgcggccttcttccgatccgggtttcgaaaaaacgatgaaatg
aaagctatggatgttttaccaattttgaaggaaaaagttgcatacctttcaggtgggaga
gataaacgtggaggtcccattttaacgtttccggcccgcagcaatcatgacagaatacga
caggaggatctcaggagactcatttcctatctagcctgtattcccagcgaggaggtctgc
aagcgtggcttcacggtgatcgtggacatgcgtgggtccaagtgggactccatcaagccc
cttctgaagatcctgcaggagtccttcccctgctgcatccatgtggccctgatcatcaag
ccagacaacttctggcagaaacagaggactaattttggcagttctaaatttgaatttgag
acaaatatggtctctttagaaggccttaccaaagtagttgatccttctcagctaactcct
gagtttgatggctgcctggaatacaaccacgaagaatggattgaaatcagagttgctttt
gaagactacattagcaatgccacccacatgctgtctcggctggaggaacttcaggacatc
ctagctaagaaggagctgcctcaggatttagagggggctcggaatatgatcgaggaacat
tctcagctgaagaagaaggtgattaaggcccccatcgaggacctggatttggagggacag
aagctgcttcagaggatacagagcagtgaaagctttcccaaaaagaactcaggctcaggc
aatgcggacctgcagaacctcttgcccaaggtgtccaccatgctggaccggctgcactcg
acacggcagcatctgcaccagatgtggcatgtgaggaagctgaagctggaccagtgcttc
cagctgaggctgtttgaacaggatgctgagaagatgtttgactggatcacacacaacaaa
ggcctgtttctaaacagctacacagagattgggaccagccaccctcatgccatggagctt
cagacgcagcacaatcactttgccatgaactgtatgaacgtgtatgtaaatataaaccgc
atcatgtcggtggccaatcgtctggtggagtctggccactatgcctcgcagcagatcagg
cagatcgcgagtcagctggagcaggagtggaaggcgtttgcggcagccctggatgagcgg
agcaccttgctggacatgtcctccattttccaccagaaggccgaaaagtatatgagcaac
gtggattcatggtgtaaagcttgcggtgaggtagaccttccctcagagctgcaggaccta
gaagatgccattcatcaccaccagggaatatatgaacatatcactcttgcttattctgag
gtcagccaagatgggaagtcgctccttgacaagctccagcggcccttgactcccggcagc
tccgattccctgacagcctctgccaactactccaaggccgtgcaccatgtcctggatgtc
atccacgaggtgctgcaccaccagcggcagctggagaacatctggcaacaccgcaaggtc
cggctgcatcagaggctgcagctgtgtgttttccagcaggacgttcagcaggtgctagac
tggatcgagaaccacggagaagcatttctgagcaaacatacaggtgtggggaaatctctt
catcgggccagagcattgcagaaacgtcatgaagattttgaagaagtggcacagaacaca
tacaccaatgcggataaattactggaagcagcagaacagctggctcagactggggaatgt
gaccccgaagagatttatcaggctgcccatcagctggaagaccggattcaagatttcgtt
cggcgtgttgagcagcgaaagatcctactggacatgtcagtgtcctttcacacccatgtg
aaagagctgtggacgtggctggaggagctgcagaaggagctgctggacgacgtgtatgcc
gagtcggtggaggccgtgcaggacctcatcaagcgctttggccagcagcagcagaccacc
ctgcaggtgactgtcaacgtgatcaaggaaggggaggacctcatccagcagctcagggac
tctgccatctccagtaacaagaccccccacaacagctccatcaaccacattgagacggtg
ctgcagcagctggacgaggcgcagtcgcagatggaggagctcttccaggagcgcaagatc
aagctggagctcttcctgcagctgcgcatcttcgagagggacgccatcgacattatctca
gacctcgagtcttggaatgatgagctttctcagcaaatgaatgacttcgacacagaagat
ctcacgattgcagagcagcgcctccagcaccatgcagacaaagccttgaccatgaacaac
ttgacttttgacgtcatccaccaagggcaagatcttctgcagtatgtcaatgaggtccag
gcctctggtgtggagctgctgtgtgatagagatgtagacatggcaactcgggtccaggac
ctgctggagtttcttcatgaaaaacagcaggaattggatttagccgcagagcagcatcgg
aaacacctggagcagtgcgtgcagctgcgccacctgcaggcagaagtgaaacaggtgctg
ggttggatccgcaacggagagtccatgttaaatgccggacttatcacagccagctcgtta
caagaggcagagcagctccagcgagagcacgagcagttccagcatgccattgagaaaaca
catcagagcgcgctgcaggtgcagcagaaggcagaagccatgctacaggccaaccactac
gacatggacatgatccgggactgcgccgagaaggtggcgtctcactggcaacagctcatg
ctcaagatggaagatcgcctcaagctcgtcaacgcctctgtcgctttctacaaaacctca
gagcaggtctgcagcgtcctcgagagcctggaacaggagtacaagagagaagaagactgg
tgtggcggggcggataagctgggcccaaactctgagacggaccacgtgacgcccatgatc
agcaagcacctggagcagaaggaggcattcctgaaggcttgcacccttgctcggaggaat
gcagacgtcttcctgaaatacctgcacaggaacagcgtgaacatgccaggaatggtgacg
cacatcaaagctcctgaacagcaagtgaaaaatatcttgaatgaactcttccaacgggag
aacagggtattgcattactggaccatgaggaagagacggctggaccagtgtcagcagtac
gtggtctttgagaggagtgccaagcaggctttggaatggatccatgacaatggcgagttc
tacctttccacacacacctccacgggctccagtatacagcacacccaggagctcctgaaa
gagcacgaggagttccagataactgcaaagcaaaccaaagagagagtgaagctattgata
cagctggctgatggcttttgtgaaaaagggcatgcccatgcggcagagataaaaaaatgt
gttactgctgtggataagaggtacagagatttctctctgcggatggagaagtacaggacc
tctttggaaaaagccctggggatttcttcagattccaacaaatcgagtaaaagtctccag
ctagatatcattccagccagtatccctggctcagaggtgaaacttcgagatgctgctcat
gaacttaatgaagagaagcggaaatctgcccgcaggaaagagttcataatggctgagctc
attcaaactgaaaaggcttatgtaagagacctccgggaatgtatggatacgtacctgtgg
gaaatgaccagtggcgtggaagagattccacctggcattgtaaacaaagaactcatcatc
ttcggaaacatgcaagaaatctacgaatttcataataacatattcctaaaggagctggaa
aaatatgaacagttgccagaggatgttggacattgttttgttacttgggcagacaagttt
cagatgtatgtcacatattgcaaaaataagcctgattctactcagctgatattggaacat
gcagggtcctattttgacgagatacagcagcgacatggattagccaattccatttcttcc
taccttattaaaccagttcagcgaataacgaagtatcagctccttttaaaagagctgctg
acgtgctgtgaggaaggaaagggagagattaaagatggcctggaggtgatgctcagcgtg
ccgaagcgagccaatgatgccatgcacctcagcatgctggaagggtttgatgaaaacatt
gagtctcagggagaactcatcctacaggaatccttccaagtgtgggacccaaaaacctta
attcgaaagggtcgagaacggcatctcttcctttttgaaatgtccttagtatttagtaaa
gaagtgaaagattccagtgggagaagcaagtacctttataaaagcaaattgtttacctca
gagttgggtgtcacagaacatgttgaaggagacccttgcaaatttgcactgtgggtgggg
agaacaccaacttcagataataaaattgtccttaaggcttccagcatagagaacaagcag
gactggataaagcatatccgcgaagtcatccaggagcggacgatccacctgaagggagcc
ctgaaggagcccattcacatccctaagaccgctcccgccacaagacagaagggaaggagg
gatggagaggatctggacagccaaggagacggcagcagccagcctgatacgatttccatc
gcctcacggacgtctcagaacacgctggacagcgataagctctctggtggctgtgagctg
acagtggtgatccatgacttcaccgcttgcaacagcaacgagctgaccatccgacggggc
cagaccgtggaagttctggagcggccgcatgacaagcctgactggtgtctggtgcggaca
actgaccgctccccagcggcagaaggcctggtcccctgtggttcactgtgcatcgcccac
tccagaagtagcatggaaatggagggcatcttcaaccacaaagactcgctctccgtctcc
agcaatgacgccagtccacccgcatccgtggcttccctccagccccacatgatcggggcc
cagagctcgccgggccccaagcggccgggcaacaccctgcgcaagtggctcaccagcccc
gtgcggcggctcagcagcggcaaggccgacgggcacgtgaagaagctggcgcacaagcac
aagaagagccgcgaggtccgcaagagcgccgacgccggctcgcagaaggactccgacgac
agtgcggccaccccgcaggacgagacggtcgaggagagaggccggaacgagggcctgagc
agcggtactctctccaaatcctcctcctcggggatgcagagctgtggagaagaggaaggc
gaggagggggccgacgccgtgcccctgccgccacccatggccatccagcagcacagcctc
ctccagccagactcacaggatgacaaggcctcttctcggttattagtccgccccaccagc
tccgaaacaccgagtgcagccgagctcgtcagtgcaattgaggaactcgtgaaaagcaag
atggcactggaggatcgccccagctcactccttgttgaccagggagatagtagcagccct
tccttcaacccttcggataattcccttctctcttcctcctcgcccattgatgagatggaa
gaaaggaaatccagctctttaaagagaagacactacgttttgcaagaactagtggagaca
gagcgtgactatgtgcgggaccttggctatgtggttgagggctacatggcacttatgaaa
gaagatggtgttcctgatgacatgaaaggaaaagacaaaattgtgttcggcaacatccat
cagatttacgactggcacagagacttttttttaggagagttagagaagtgccttgaagat
ccagaaaaactaggatccctttttgttaaacacgagagaaggttgcacatgtacatagct
tattgtcaaaataaaccaaagtctgagcacattgtctcagaatacattgatacctttttt
gaggacttaaagcagcgtcttggccacaggttacagctcacagatctgttgatcaaacca
gtgcagagaatcatgaagtatcagctgttactgaaggacttcctcaagtattccaaaaag
gccagcctggatacatcagaattagagagagctgtggaagtcatgtgcatagtacccagg
cggtgcaacgacatgatgaacgtggggcggctgcaaggattcgacgggaaaatcgttgcc
cagggtaaactgctcttgcaggacacattcttggtcacagaccaagatgcaggacttctg
cctcgctgcagagagaggcgcatcttcctctttgagcagatcgtcatattcagcgaacca
cttgataaaaagaagggcttctccatgccgggattcctgtttaagaacagtatcaaggtg
agttgcctttgcctggaggaaaatgtggaaaatgatccctgtaaatttgctctgacatcg
aggacgggtgacgtggtagagaccttcattttgcattcatctagtccaagtgtccggcaa
acttggatccatgaaatcaaccaaattttagaaaaccagcgcaattttttaaatgccttg
acatcgccaatcgagtaccagaggaaccacagcgggggcggcggcggcggcggcagcggg
ggcagcggcgggggtgggggcagcggcggcggcggggcccccagtggcggcagcggccac
agtggcggccccagcagctgcggcggcgcccccagcacgagcaggagccggccctcccgg
atcccccagcctgtccgacaccacccccccgtgctggtctcctctgcagcctcgagccag
gcagaggcagacaagatgtcaggtacgtccacccccgggccctccctgcctccccctggc
gcggcccccgaggccggccccagcgcgcccagcaggcggccccccggcgcggacgccgag
gggtccgagcgagaagcggagccgatccccaagatgaaggtgctggagagccccaggaaa
ggcgccgcgaacgcctcggggtcgagcccagacgcccccgccaaggacgcgcgcgctagc
ctgggcaccctgccgcttgggaagccccgggccggggccgcttcgccgctgaactcgccg
ctctccagcgcggtcccttctctcggcaaggagcccttcccccccagcagccccctgcag
aaggggggctccttctggagctccatccccgcctcccccgccagccgacccggctccttc
accttcccgggggacagcgactccctccagcggcagacaccccgccacgcggcccctggc
aaggatactgaccgcatgagcacgtgctcctcggccagcgagcagtccgtgcagtccacc
cagagcaacgggagtgaaagcagcagcagtagcaacatctccaccatgttggtgacacac
gattacacggcagtgaaggaggatgagatcaacgtctaccaaggagaggtcgttcaaatt
ctggccagcaaccagcagaacatgtttctggtgttccgagccgccactgaccagtgcccc
gcagctgagggctggattccaggctttgtcctgggccacaccagtgcagtcatcgtggag
aacccggacgggactctcaagaagtcaacatcttggcacacagcactccgtttaaggaaa
aaatctgagaaaaaagataaagacggcaaaagggaaggcaagttagagaacggttatcgg
aagtcacgggaaggactcagcaacaaggtatctgtgaagcttctcaatcccaactacatt
tatgacgttcccccagaattcgtcattccattgagtgaggtcacgtgtgagacaggggag
accgttgttcttagatgtcgagtctgtggccgccccaaagcctcaattacctggaagggc
cctgaacacaacaccttgaacaacgatggtcactacagcatctcctacagtgacctggga
gaggccacgctgaagattgtgggcgtgaccacggaagatgacggcatctacacgtgcatc
gctgtcaatgacatgggttcagcctcatcgtcggccagcctgagggtcctaggtccaggg
atggatgggatcatggtgacctggaaagacaactttgactccttctacagtgaagtggct
gagcttggcaggggcagattctctgtcgttaagaaatgtgatcagaaaggaaccaagcga
gcagtggccactaagtttgtgaacaagaagttgatgaagcgcgaccaggtcacccatgag
cttggcatcctgcagagcctccagcaccccctgcttgtcggcctcctcgacacctttgag
acccccaccagctacatcctggtcttagaaatggctgaccagggtcgcctcctggactgc
gtggtgcgatggggaagcctcactgaagggaagatcagggcgcacctgggggaggttctg
gaagctgtccggtacctgcacaactgcaggatagcacacctggacctaaagcctgagaat
atcctggtggatgagagtttagccaagccaaccatcaaactggctgactttggagatgct
gttcagctcaacacgacctactacatccaccagttactggggaaccctgaattcgcagcc
cctgaaatcatcctcgggaaccctgtctccctgacctcggatacgtggagtgttggagtg
ctcacatacgtacttcttagtggcgtgtcccccttcctggatgacagtgtggaagagacc
tgcctgaacatttgccgcttagactttagcttcccagatgactactttaaaggagtgagc
cagaaggccaaggagttcgtgtgcttcctcctgcaggaggaccccgccaagcgtccctcg
gctgcgctggccctccaggagcagtggctgcaggccggcaacggcagaagcacgggcgtc
ctcgacacgtccagactgacttccttcattgagcggcgcaaacaccagaatgatgttcga
cctatccgtagcattaaaaactttctgcagagcaggcttctgcctagagtttga

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