KEGG   Homo sapiens (human): 728
Entry
728               CDS       T01001                                 
Symbol
C5AR1, C5A, C5AR, C5R1, CD88
Name
(RefSeq) complement C5a receptor 1
  KO
K04010  C5a anaphylatoxin chemotactic receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04936  Alcoholic liver disease
hsa05150  Staphylococcus aureus infection
hsa05171  Coronavirus disease - COVID-19
Drug target
Avacopan: D11093<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    728 (C5AR1)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    728 (C5AR1)
   04613 Neutrophil extracellular trap formation
    728 (C5AR1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    728 (C5AR1)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    728 (C5AR1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    728 (C5AR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    728 (C5AR1)
   04090 CD molecules [BR:hsa04090]
    728 (C5AR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Anaphylatoxin
    728 (C5AR1)
CD molecules [BR:hsa04090]
 Proteins
  728 (C5AR1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx 7TM_GPCR_Srw
Other DBs
NCBI-GeneID: 728
NCBI-ProteinID: NP_001727
OMIM: 113995
HGNC: 1338
Ensembl: ENSG00000197405
UniProt: P21730
Structure
Position
19:47307477..47322066
AA seq 350 aa
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
NT seq 1053 nt   +upstreamnt  +downstreamnt
atggactccttcaattataccacccctgattatgggcactatgatgacaaggataccctg
gacctcaacacccctgtggataaaacttctaacacgctgcgtgttccagacatcctggcc
ttggtcatctttgcagtcgtcttcctggtgggagtgctgggcaatgccctggtggtctgg
gtgacggcattcgaggccaagcggaccatcaatgccatctggttcctcaacttggcggta
gccgacttcctctcctgcctggcgctgcccatcttgttcacgtccattgtacagcatcac
cactggccctttggcggggccgcctgcagcatcctgccctccctcatcctgctcaacatg
tacgccagcatcctgctcctggccaccatcagcgccgaccgctttctgctggtgtttaaa
cccatctggtgccagaacttccgaggggctggcttggcctggatcgcctgtgccgtggct
tggggtttagccctgctgctgaccataccctccttcctgtaccgggtggtccgggaggag
tactttccaccaaaggtgttgtgtggcgtggactacagccacgacaaacggcgggagcga
gccgtggccatcgtccggctggtcctgggcttcctgtggcctctactcacgctcacgatt
tgttacactttcatcctgctccggacgtggagccgcagggccacgcggtccaccaagaca
ctcaaggtggtggtggcagtggtggccagtttctttatcttctggttgccctaccaggtg
acggggataatgatgtccttcctggagccatcgtcacccaccttcctgctgctgaagaag
ctggactccctgtgtgtctcctttgcctacatcaactgctgcatcaaccccatcatctac
gtggtggccggccagggcttccagggccgactgcggaaatccctccccagcctcctccgg
aacgtgttgactgaagagtccgtggttagggagagcaagtcattcacgcgctccacagtg
gacactatggcccagaagacccaggcagtgtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (19)   
   RefSeq(nuc) (5)   
   GenBank (7)   
   EMBL (7)   
3D Structure (15)   
   PDB (15)   
Protein domain (5)   
   Pfam (5)   
All databases (71)   

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