KEGG   Homo sapiens (human): 7345
Entry
7345              CDS       T01001                                 
Symbol
UCHL1, HEL-117, HEL-S-53, NDGOA, PARK5, PGP_9.5, PGP9.5, PGP95, SPG79, SPG79A, UCHL-1, Uch-L1
Name
(RefSeq) ubiquitin C-terminal hydrolase L1
  KO
K05611  ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06463  Parkinson disease
nt06466  Pathways of neurodegeneration
  Element
N01027  UCHL1-mediated hydrolysis
N01028  Mutation-inactivated UCHL1 to UCHL1-mediated hydrolysis
Disease
H00057  Parkinson disease
H00266  Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    7345 (UCHL1)
   05022 Pathways of neurodegeneration - multiple diseases
    7345 (UCHL1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7345 (UCHL1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7345 (UCHL1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     7345 (UCHL1)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C12: ubiquitin C-terminal hydrolase family
   7345 (UCHL1)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UCH
    7345 (UCHL1)
SSDB
Motif
Pfam: Peptidase_C12
Other DBs
NCBI-GeneID: 7345
NCBI-ProteinID: NP_004172
OMIM: 191342
HGNC: 12513
Ensembl: ENSG00000154277
UniProt: P09936 V9HW74
Structure
Position
4:41256928..41268455
AA seq 223 aa
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
NT seq 672 nt   +upstreamnt  +downstreamnt
atgcagctcaagccgatggagatcaaccccgagatgctgaacaaagtgctgtcccggctg
ggggtcgccggccagtggcgcttcgtggacgtgctggggctggaagaggagtctctgggc
tcggtgccagcgcctgcctgcgcgctgctgctgctgtttcccctcacggcccagcatgag
aacttcaggaaaaagcagattgaagagctgaagggacaagaagttagtcctaaagtgtac
ttcatgaagcagaccattgggaattcctgtggcacaatcggacttattcacgcagtggcc
aataatcaagacaaactgggatttgaggatggatcagttctgaaacagtttctttctgaa
acagagaaaatgtcccctgaagacagagcaaaatgctttgaaaagaatgaggccatacag
gcagcccatgatgccgtggcacaggaaggccaatgtcgggtagatgacaaggtgaatttc
cattttattctgtttaacaacgtggatggccacctctatgaacttgatggacgaatgcct
tttccggtgaaccatggcgccagttcagaggacaccctgctgaaggacgctgccaaggtc
tgcagagaattcaccgagcgtgagcaaggagaagtccgcttctctgccgtggctctctgc
aaggcagcctaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (4)   
   KEGG NETWORK (4)   
Disease (6)   
   KEGG DISEASE (2)   
   OMIM (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (22)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
3D Structure (11)   
   PDB (11)   
Protein domain (1)   
   Pfam (1)   
All databases (87)   

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