KEGG   Homo sapiens (human): 7465
Entry
7465              CDS       T01001                                 
Symbol
WEE1, WEE1A, WEE1hu
Name
(RefSeq) WEE1 G2 checkpoint kinase
  KO
K06632  wee1-like protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa05170  Human immunodeficiency virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
  Element
N00459  WEE1-Cell cycle G2/M
N00460  HIV Vpr to WEE1-cell cycle G2M
Drug target
Adavosertib: D11361
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    7465 (WEE1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    7465 (WEE1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7465 (WEE1)
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    7465 (WEE1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     7465 (WEE1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  WEE family
   7465 (WEE1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    7465 (WEE1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr
Other DBs
NCBI-GeneID: 7465
NCBI-ProteinID: NP_003381
OMIM: 193525
HGNC: 12761
Ensembl: ENSG00000166483
UniProt: P30291 Q86V29
Structure
Position
11:9573670..9589985
AA seq 646 aa
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
NT seq 1941 nt   +upstreamnt  +downstreamnt
atgagcttcctgagccgacagcagccgccgccaccccgccgcgccggggcggcctgcacc
ttgcggcagaagctgatcttctcgccctgcagcgactgtgaggaggaggaagaagaggag
gaggaggagggcagcggccacagcaccggggaggactcggcctttcaagagcccgactcg
ccgctgccgcccgcgcggagccccacggagcccgggcccgagcgccgccgctcgcccggg
ccggcccccggcagccccggcgagctggaggaggacctgttgctgcccggcgcctgcccg
ggcgcggacgaggcgggcggtggggcggagggcgactcgtgggaggaggagggcttcggc
tcctcgtcgccggtcaagtcgccggcggccccctacttcctgggtagctctttctcgccg
gtgcgctgcggcggcccaggagatgcgtcgccgcggggttgcggggcgcgccgggcgggc
gaaggccgccgctcgccgcggccggaccacccgggcaccccgccacacaagaccttccgc
aagctgcgactcttcgacaccccgcacacgcccaagagtttgctctccaaagctcgggga
attgattccagctctgttaaactccggggtagttctctcttcatggatacagaaaaatca
ggaaaaagggaatttgatgtgcgacagactcctcaagtgaatattaatccttttactccg
gattctttgttgcttcattcctcaggacagtgtcgtcgtagaaagagaacgtattggaat
gattcctgtggtgaagacatggaagccagtgattatgagcttgaagatgaaacaagacct
gctaagagaattacaattactgaaagcaatatgaagtcccggtatacaacagaatttcat
gagctagagaaaatcggctctggagaatttggttctgtatttaagtgtgtgaagaggctg
gatggatgcatttatgccattaagcgatcaaaaaagccattggcgggctctgttgatgag
cagaacgctttgagagaagtatatgctcatgcagtgcttggacagcattctcatgtagtt
cgatatttctctgcgtgggcagaagatgatcatatgcttatacagaatgaatattgtaat
ggtggaagtttagctgatgctataagtgaaaactacagaatcatgagttactttaaagaa
gcagagttgaaggatctccttttgcaagttggccgaggcttgaggtatattcattcaatg
tctttggttcacatggatataaaacctagtaatattttcatatctcgaacctcaatccca
aatgctgcctctgaagaaggagacgaagatgattgggcatccaacaaagttatgtttaaa
ataggtgatcttgggcatgtaacaaggatctccagtccacaagttgaagagggcgatagt
cgttttcttgcaaatgaagttttacaggagaattatacccatctaccaaaagcagatatt
tttgcgcttgccctcacagtggtatgtgctgctggtgctgaacctcttccgagaaatgga
gatcaatggcatgaaatcagacagggtagattacctcggataccacaagtgctttcccaa
gaatttacagagttgctaaaagttatgattcatccagatccagagagaagaccttcagca
atggcactggtaaagcattcagtattgctgtccgcttctagaaagagtgcagaacaatta
cgaatagaattgaatgccgaaaagttcaaaaattcacttttacaaaaagaactcaagaaa
gcacagatggcaaaagctgcagctgaggaaagagcactcttcactgaccggatggccact
aggtccaccacccagagtaatagaacatctcgacttattggaaagaaaatgaaccgctct
gtcagccttactatatactga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (18)   
   RefSeq(nuc) (4)   
   GenBank (7)   
   EMBL (7)   
3D Structure (22)   
   PDB (22)   
Protein domain (2)   
   Pfam (2)   
All databases (99)   

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