KEGG   Homo sapiens (human): 785
Entry
785               CDS       T01001                                 
Symbol
CACNB4, CAB4, CACNLB4, EA5, EIG9, EJM, EJM4, EJM6
Name
(RefSeq) calcium voltage-gated channel auxiliary subunit beta 4
  KO
K04865  voltage-dependent calcium channel beta-4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04260  Cardiac muscle contraction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04921  Oxytocin signaling pathway
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
Network
nt06528  Calcium signaling
  Element
N01637  Ca2+ entry, Voltage-gated Ca2+ channel
N01638  Skeletal-type VGCC-RYR signaling
N01639  Cardiac-type VGCC-RYR signaling
Disease
H00749  Episodic ataxias
H00808  Idiopathic generalized epilepsies
H02217  Juvenile myoclonic epilepsy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    785 (CACNB4)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    785 (CACNB4)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    785 (CACNB4)
   04261 Adrenergic signaling in cardiomyocytes
    785 (CACNB4)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    785 (CACNB4)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    785 (CACNB4)
   05414 Dilated cardiomyopathy
    785 (CACNB4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    785 (CACNB4)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   785 (CACNB4)
SSDB
Motif
Pfam: Guanylate_kin VGCC_beta4Aa_N SH3_1
Other DBs
NCBI-GeneID: 785
NCBI-ProteinID: NP_000717
OMIM: 601949
HGNC: 1404
Ensembl: ENSG00000182389
UniProt: O00305
Structure
Position
2:complement(151832771..152099167)
AA seq 520 aa
MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPS
DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISF
DAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNS
SSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQK
ALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIF
ELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQ
LVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGS
TALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQH
SRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL
NT seq 1563 nt   +upstreamnt  +downstreamnt
atgtcctcctcctcctacgccaagaacgggaccgcggacgggccgcactcccccacctcg
caggtggcccgaggcaccacaacccggaggagcaggttgaaaagatccgatggcagcacc
acttcgaccagcttcatcctcagacagggttcagcggattcctacacaagcaggccgtct
gactccgatgtctctttggaagaggaccgggaagcaattcgacaggagagagaacagcaa
gcagctatccagcttgagagagcaaagtccaaacctgtagcatttgccgtgaagacaaat
gtgagctactgcggcgccctggacgaggatgtgcctgttccaagcacagctatctccttt
gatgctaaagactttctacatattaaagagaaatataacaatgattggtggataggaagg
ctggtgaaagagggctgtgaaattggcttcattccaagtccactcagattggagaacata
cggatccagcaagaacaaaaaagaggacgttttcacggagggaaatcaagtggaaattct
tcttcaagtcttggagaaatggtatctgggacattccgagcaactcccacatcaacagca
aaacagaagcaaaaagtgacggagcacattcctccttacgatgttgtaccgtcaatgcgt
ccggtggtgttagtggggccgtcactgaaaggttacgaggtaacagacatgatgcagaaa
gccctctttgatttcctgaagcacaggtttgatgggaggatttcaataacgagagtgaca
gctgacatttctcttgctaagaggtctgtcctaaataatcccagcaagagagcaataatt
gaacgttcgaacacccggtccagcttagcggaagtacaaagtgaaattgaaagaatcttt
gagttggcaagatctttgcaactggttgttcttgatgcagacaccatcaatcacccagca
caacttataaagacttccttagcaccaattattgttcatgtaaaagtctcatctccaaag
gttttacagcggttgattaaatctagaggaaagtcacaaagtaaacacttgaatgttcaa
ctggtggcagctgataaacttgcacaatgccccccagaaatgtttgatgttatattggat
gaaaatcagcttgaggatgcatgtgaacatctaggggagtacctggaggcgtactggcgt
gccacccacacaaccagtagcacacccatgaccccgctgctgggaaggaatttgggctcc
acggcactctcaccatatcccacagcaatttctgggttacagagtcagcgaatgaggcac
agcaaccactccacagagaactctccaattgaaagacgaagtctaatgacctctgatgaa
aattatcacaatgaaagggctcggaagagtaggaaccgcttgtcttccagttctcagcat
agccgagatcattaccctcttgtggaagaagattaccctgactcataccaggacacttac
aaaccccataggaaccgaggatcacctgggggatatagccatgactcccgacataggctt
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (4)   
   KEGG NETWORK (4)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (32)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (30)   
DNA sequence (71)   
   RefSeq(nuc) (31)   
   GenBank (20)   
   EMBL (20)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (134)   

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