KEGG   Homo sapiens (human): 79054
Entry
79054             CDS       T01001                                 
Symbol
TRPM8, LTRPC6, LTrpC-6, TRPP8, trp-p8
Name
(RefSeq) transient receptor potential cation channel subfamily M member 8
  KO
K04983  transient receptor potential cation channel subfamily M member 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04750  Inflammatory mediator regulation of TRP channels
Drug target
Menthol (DG01385): D00064<JP> D04849 D04918
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    79054 (TRPM8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    79054 (TRPM8)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   79054 (TRPM8)
SSDB
Motif
Pfam: LSDAT_euk LSDAT_prok Ion_trans
Other DBs
NCBI-GeneID: 79054
NCBI-ProteinID: NP_076985
OMIM: 606678
HGNC: 17961
Ensembl: ENSG00000144481
UniProt: Q7Z2W7 W8DTH1
Structure
Position
2:233917373..234019522
AA seq 1104 aa
MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY
LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE
QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC
DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY
FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH
RFRQLDTKLNDLKGLLKEIANKIK
NT seq 3315 nt   +upstreamnt  +downstreamnt
atgtcctttcgggcagccaggctcagcatgaggaacagaaggaatgacactctggacagc
acccggaccctgtactccagcgcgtctcggagcacagacttgtcttacagtgaaagcgac
ttggtgaattttattcaagcaaattttaagaaacgagaatgtgtcttctttaccaaagat
tccaaggccacggagaatgtgtgcaagtgtggctatgcccagagccagcacatggaaggc
acccagatcaaccaaagtgagaaatggaactacaagaaacacaccaaggaatttcctacc
gacgcctttggggatattcagtttgagacactggggaagaaagggaagtatatacgtctg
tcctgcgacacggacgcggaaatcctttacgagctgctgacccagcactggcacctgaaa
acacccaacctggtcatttctgtgaccgggggcgccaagaacttcgccctgaagccgcgc
atgcgcaagatcttcagccggctcatctacatcgcgcagtccaaaggtgcttggattctc
acgggaggcacccattatggcctgatgaagtacatcggggaggtggtgagagataacacc
atcagcaggagttcagaggagaatattgtggccattggcatagcagcttggggcatggtc
tccaaccgggacaccctcatcaggaattgcgatgctgagggctattttttagcccagtac
cttatggatgacttcacaagagatccactgtatatcctggacaacaaccacacacatttg
ctgctcgtggacaatggctgtcatggacatcccactgtcgaagcaaagctccggaatcag
ctagagaagtatatctctgagcgcactattcaagattccaactatggtggcaagatcccc
attgtgtgttttgcccaaggaggtggaaaagagactttgaaagccatcaatacctccatc
aaaaataaaattccttgtgtggtggtggaaggctcgggccagatcgctgatgtgatcgct
agcctggtggaggtggaggatgccctgacatcttctgccgtcaaggagaagctggtgcgc
tttttaccccgcacggtgtcccggctgcctgaggaggagactgagagttggatcaaatgg
ctcaaagaaattctcgaatgttctcacctattaacagttattaaaatggaagaagctggg
gatgaaattgtgagcaatgccatctcctacgctctatacaaagccttcagcaccagtgag
caagacaaggataactggaatgggcagctgaagcttctgctggagtggaaccagctggac
ttagccaatgatgagattttcaccaatgaccgccgatgggagtctgctgaccttcaagaa
gtcatgtttacggctctcataaaggacagacccaagtttgtccgcctctttctggagaat
ggcttgaacctacggaagtttctcacccatgatgtcctcactgaactcttctccaaccac
ttcagcacgcttgtgtaccggaatctgcagatcgccaagaattcctataatgatgccctc
ctcacgtttgtctggaaactggttgcgaacttccgaagaggcttccggaaggaagacaga
aatggccgggacgagatggacatagaactccacgacgtgtctcctattactcggcacccc
ctgcaagctctcttcatctgggccattcttcagaataagaaggaactctccaaagtcatt
tgggagcagaccaggggctgcactctggcagccctgggagccagcaagcttctgaagact
ctggccaaagtgaagaacgacatcaatgctgctggggagtccgaggagctggctaatgag
tacgagacccgggctgttgagctgttcactgagtgttacagcagcgatgaagacttggca
gaacagctgctggtctattcctgtgaagcttggggtggaagcaactgtctggagctggcg
gtggaggccacagaccagcatttcatcgcccagcctggggtccagaattttctttctaag
caatggtatggagagatttcccgagacaccaagaactggaagattatcctgtgtctgttt
attatacccttggtgggctgtggctttgtatcatttaggaagaaacctgtcgacaagcac
aagaagctgctttggtactatgtggcgttcttcacctcccccttcgtggtcttctcctgg
aatgtggtcttctacatcgccttcctcctgctgtttgcctacgtgctgctcatggatttc
cattcggtgccacacccccccgagctggtcctgtactcgctggtctttgtcctcttctgt
gatgaagtgagacagtggtacgtaaatggggtgaattattttactgacctgtggaatgtg
atggacacgctggggcttttttacttcatagcaggaattgtatttcggctccactcttct
aataaaagctctttgtattctggacgagtcattttctgtctggactacattattttcact
ctaagattgatccacatttttactgtaagcagaaacttaggacccaagattataatgctg
cagaggatgctgatcgatgtgttcttcttcctgttcctctttgcggtgtggatggtggcc
tttggcgtggccaggcaagggatccttaggcagaatgagcagcgctggaggtggatattc
cgttcggtcatctacgagccctacctggccatgttcggccaggtgcccagtgacgtggat
ggtaccacgtatgactttgcccactgcaccttcactgggaatgagtccaagccactgtgt
gtggagctggatgagcacaacctgccccggttccccgagtggatcaccatccccctggtg
tgcatctacatgttatccaccaacatcctgctggtcaacctgctggtcgccatgtttggc
tacacggtgggcaccgtccaggagaacaatgaccaggtctggaagttccagaggtacttc
ctggtgcaggagtactgcagccgcctcaatatccccttccccttcatcgtcttcgcttac
ttctacatggtggtgaagaagtgcttcaagtgttgctgcaaggagaaaaacatggagtct
tctgtctgctgtttcaaaaatgaagacaatgagactctggcatgggagggtgtcatgaag
gaaaactaccttgtcaagatcaacacaaaagccaacgacacctcagaggaaatgaggcat
cgatttagacaactggatacaaagcttaatgatctcaagggtcttctgaaagagattgct
aataaaatcaaataa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (36)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (33)   
DNA sequence (131)   
   RefSeq(nuc) (33)   
   GenBank (49)   
   EMBL (49)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (192)   

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