KEGG   Homo sapiens (human): 79792
Entry
79792             CDS       T01001                                 
Symbol
GSDMD, DF5L, DFNA5L, FKSG10, GSDMDC1
Name
(RefSeq) gasdermin D
  KO
K20917  gasdermin-D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04613  Neutrophil extracellular trap formation
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    79792 (GSDMD)
   04621 NOD-like receptor signaling pathway
    79792 (GSDMD)
   04623 Cytosolic DNA-sensing pathway
    79792 (GSDMD)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    79792 (GSDMD)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    79792 (GSDMD)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   79792 (GSDMD)
SSDB
Motif
Pfam: Gasdermin Gasdermin_C
Other DBs
NCBI-GeneID: 79792
NCBI-ProteinID: NP_001159709
OMIM: 617042
HGNC: 25697
Ensembl: ENSG00000104518
UniProt: P57764
Structure
Position
8:143553387..143563062
AA seq 484 aa
MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLS
IKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNV
YSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREG
SGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTF
QPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKE
LELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSS
GMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERST
MSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLS
QEPH
NT seq 1455 nt   +upstreamnt  +downstreamnt
atggggtcggcctttgagcgggtagtccggagagtggtccaggagctggaccatggtggg
gagttcatccctgtgaccagcctgcagagctccactggcttccagccctactgcctggtg
gttaggaagccctcaagctcatggttctggaaaccccgttataagtgtgtcaacctgtct
atcaaggacatcctggagccggatgccgcggaaccagacgtgcagcgtggcaggagcttc
cacttctacgatgccatggatgggcagatacagggcagcgtggagctggcagccccagga
caggcaaagatcgcaggcggggccgcggtgtctgacagctccagcacctcaatgaatgtg
tactcgctgagtgtggaccctaacacctggcagactctgctccatgagaggcacctgcgg
cagccagaacacaaagtcctgcagcagctgcgcagccgcggggacaacgtgtacgtggtg
actgaggtgctgcagacacagaaggaggtggaagtcacgcgcacccacaagcgggagggc
tcgggccggttttccctgcccggagccacgtgcttgcagggtgagggccagggccatctg
agccagaagaagacggtcaccatcccctcaggcagcaccctcgcattccgggtggcccag
ctggttattgactctgacttggacgtccttctcttcccggataagaagcagaggaccttc
cagccacccgcgacaggccacaagcgttccacgagcgaaggcgcctggccacagctgccc
tctggcctctccatgatgaggtgcctccacaacttcctgacagatggggtccctgcggag
ggggcgttcactgaagacttccagggcctacgggcagaggtggagaccatctccaaggaa
ctggagcttttggacagagagctgtgccagctgctgctggagggcctggagggggtgctg
cgggaccagctggccctgcgagccttggaggaggcgctggagcagggccagagccttggg
ccggtggagcccctggacggtccagcaggtgctgtcctggagtgcctggtgttgtcctcc
ggaatgctggtgccggaactcgctatccctgttgtctacctgctgggggcactgaccatg
ctgagtgaaacgcagcacaagctgctggcggaggcgctggagtcgcagaccctgttgggg
ccgctcgagctggtgggcagcctcttggagcagagtgccccgtggcaggagcgcagcacc
atgtccctgccccccgggctcctggggaacagctggggcgaaggagcaccggcctgggtc
ttgctggacgagtgtggcctagagctgggggaggacactccccacgtgtgctgggagccg
caggcccagggccgcatgtgtgcactctacgcctccctggcactgctatcaggactgagc
caggagccccactag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
3D Structure (7)   
   PDB (7)   
Protein domain (2)   
   Pfam (2)   
All databases (71)   

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