KEGG   Homo sapiens (human): 8021
Entry
8021              CDS       T01001                                 
Symbol
NUP214, CAIN, CAN, IIAE9
Name
(RefSeq) nucleoporin 214
  KO
K14317  nuclear pore complex protein Nup214
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa05014  Amyotrophic lateral sclerosis
Network
nt06464  Amyotrophic lateral sclerosis
  Element
N01152  Nuclear export of mRNA
N01153  Mutation-caused aberrant GLE1 to nuclear export of mRNA
Disease
H00003  Acute myeloid leukemia
H02536  Infection-induced acute encephalopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03013 Nucleocytoplasmic transport
    8021 (NUP214)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    8021 (NUP214)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    8021 (NUP214)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    Nuclear pore complex
     8021 (NUP214)
SSDB
Motif
Pfam: Nup214_FG ANAPC4_WD40 WD40 dCache_2
Other DBs
NCBI-GeneID: 8021
NCBI-ProteinID: NP_005076
OMIM: 114350
HGNC: 8064
Ensembl: ENSG00000126883
UniProt: P35658
Structure
Position
9:131125586..131234663
AA seq 2090 aa
MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQ
IFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSII
AFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVT
ETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHP
VRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTE
RQHHYYLSYIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDS
LPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSLIKTPERL
SLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPT
VFSFGSSSLKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVA
PSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPV
SSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVP
SMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEEL
KARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVE
EAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHL
EQKKKQRHLLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAV
PSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVR
STAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVR
TPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAP
SPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMG
SSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAV
TSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGG
SKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGEL
LFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVL
GKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFS
FGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSA
LPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSL
VALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASST
TSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAAS
TAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAA
SVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQ
SNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGI
VFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSN
LFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPP
TFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLAS
QNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS
NT seq 6273 nt   +upstreamnt  +downstreamnt
atgggagacgagatggatgccatgattcccgagcgggagatgaaggattttcagtttaga
gcgctaaagaaggtgagaatctttgactcccctgaggaattgcccaaggaacgctcgagt
ctgcttgctgtgtccaacaaatatggtctggtcttcgctggtggagccagtggcttgcag
atttttcctactaaaaatcttcttattcaaaataaacccggagatgatcccaacaaaata
gttgataaagtccaaggcttgctagttcctatgaaattcccaatccatcacctggccttg
agctgtgataacctcacactctctgcgtgcatgatgtccagtgaatatggttccattatt
gctttttttgatgttcgcacattctcaaatgaggctaaacagcaaaaacgcccatttgcc
tatcataagcttttgaaagatgcaggaggcatggtgattgatatgaagtggaaccccact
gtcccctccatggtggcagtttgtctggctgatggtagtattgctgtcctgcaagtcacg
gaaacagtgaaagtatgtgcaactcttccttccacggtagcagtaacctctgtgtgctgg
agccccaaaggaaagcagctggcagtgggaaaacagaatggaactgtggtccagtatctt
cctactttgcaggaaaaaaaagtcattccttgtcctccgttttatgagtcagatcatcct
gtcagagttctggatgtgctgtggattggtacctacgtcttcgccatagtgtatgctgct
gcagatgggaccctggaaacgtctccagatgtggtgatggctctactaccgaaaaaagaa
gaaaagcacccagagatatttgtgaactttatggagccctgttatggcagctgcacggag
agacagcatcattactacctcagttacattgaggaatgggatttagtgctggcagcatct
gcggcttcaacagaagttagtatccttgctcgacaaagtgatcagattaattgggaatct
tggctactggaggattctagtcgagctgaattgcctgtgacagacaagagtgatgactcc
ttgcccatgggagttgtcgtagactatacaaaccaagtggaaatcaccatcagtgatgaa
aagactcttcctcctgctccagttctcatgttactttcaacagatggtgtgctttgtcca
ttttatatgattaatcaaaatcctggggttaagtctctcatcaaaacaccagagcgactt
tcattagaaggagagcgacagcccaagtcaccaggaagtactcccactaccccaacctcc
tctcaagccccacagaaactggatgcttctgcagctgcagcccctgcctctctgccacct
tcatcacctgctgctcccattgccactttttctttgcttcctgctggtggagcccccact
gtgttctcctttggttcttcatctttgaagtcatctgctacggtcactggggagccccct
tcatattccagtggctccgacagctccaaagcagccccaggccctggcccatcaaccttc
tcttttgttcccccttctaaagcctccctagcccccacccctgcagcgtctcctgtggct
ccatcagctgcttcattctcctttggatcatctggttttaagcctaccctggaaagcaca
ccagtgccaagtgtgtctgctccaaatatagcaatgaagccctccttcccaccctcaacc
tctgctgtcaaagtcaaccttagtgaaaagtttactgctgcagctacctctactcctgtt
agtagctcccagagcgcacccccgatgtcgccattctcttctgcctccaagccagctgct
tctggaccactcagccaccccacacctctctcagcaccacctagttccgtgccattgaag
tcctcagtcttgccctcaccatcaggacgatctgctcagggcagttcaagcccagtgccc
tcaatggtacagaaatcacccaggataacccctccagcggcaaagccaggctctccccag
gcaaagtcacttcagcctgctgttgcagaaaagcagggacatcagtggaaagattcagat
cctgtaatggctggaattggggaggagattgcacactttcagaaggagttggaagagtta
aaagcccgaacttccaaagcctgtttccaagtgggcacttctgaggagatgaagatgctg
cgaacagaatcagatgacttgcatacctttcttttggagattaaagagaccacagagtcg
cttcatggagatataagtagcctgaaaacaactttacttgagggctttgctggtgttgag
gaagccagagaacaaaatgaaagaaatcgtgactctggttatctgcatttgctttataaa
agaccactggatcccaagagtgaagctcagcttcaggaaattcggcgccttcatcagtat
gtgaaatttgctgtccaagatgtgaatgatgttctagacttggagtgggatcagcatctg
gaacaaaagaaaaaacaaaggcacctgcttgtgccagagcgagagacactgtttaacacc
ctagccaacaatcgggaaatcatcaaccaacagaggaagaggctgaatcacctggtggat
agtcttcagcagctccgcctttacaaacagacttccctgtggagcctgtcctcggctgtt
ccttcccagagcagcattcacagttttgacagtgacctggaaagcctgtgcaatgctttg
ttgaaaaccaccatagaatctcacaccaaatccttgcccaaagtaccagccaaactgtcc
cccatgaaacaggcacaactgagaaacttcttggccaagaggaagaccccaccagtgaga
tccactgctccagccagcctgtctcgatcagcctttctgtctcagagatattatgaagac
ttggatgaagtcagctcaacgtcatctgtctcccagtctctggagagtgaagatgcacgg
acgtcctgtaaagatgacgaggcagtggttcaggcccctcggcacgcccccgtggttcgc
actccttccatccagcccagtctcttgccccatgcagcaccttttgctaaatctcacctg
gttcatggttcttcacctggtgtgatgggaacttcagtggctacatctgctagcaaaatt
attcctcaaggggccgatagcacaatgcttgccacgaaaaccgtgaaacatggtgcacct
agtccttcccaccccatctcagccccgcaggcagctgccgcagcagcactcaggcggcag
atggccagtcaggcaccagctgtaaacactttgactgaatcaacgttgaagaatgtccct
caagtggtaaatgtgcaggaattgaagaataaccctgcaaccccttctacagccatgggt
tcttcagtgccctactccacagccaaaacacctcacccagtgttgaccccagtggctgct
aaccaagccaagcaggggtctctaataaattcccttaagccatctgggcctacaccagca
tccggtcagttatcatctggtgacaaagcttcagggacagccaagatagaaacagctgtg
acttcaaccccatctgcttctgggcagttcagcaagcctttctcattttctccatcaggg
actggctttaattttgggataatcacaccaacaccgtcttctaatttcactgctgcacaa
ggggcaacaccctccactaaagagtcaagccagccggacgcattctcatctggtggggga
agcaaaccttcttatgaggccattcctgaaagctcacctccctcaggaatcacatccgca
tcaaacaccaccccaggagaacctgccgcatctagcagcagacctgtggcaccttctgga
actgctctttccaccacctctagtaagctggaaaccccaccgtccaagctgggagagctt
ctgtttccaagttctttggctggagagactctgggaagtttttcaggactgcgggttggc
caagcagatgattctacaaaaccaaccaataaggcttcatccacaagcctaactagtacc
cagccaaccaagacgtcaggcgtgccctcagggtttaattttactgcccccccggtgtta
gggaagcacacggagccccctgtgacatcctctgcaaccaccacctcagtagcaccacca
gcagccaccagcacttcctcaactgccgtttttggcagtctgccagtcaccagtgcagga
tcctctggggtcatcagttttggtgggacatctctaagtgctggcaagactagtttttca
tttggaagccaacagaccaatagcacagtgcccccatctgccccaccaccaactacagct
gccactccccttccaacatcattccccacattgtcatttggtagcctcctgagttcagca
actaccccctccctgcctatgtccgctggcagaagcacagaagaggccacttcatcagct
ttgcctgagaagccaggtgacagtgaggtctcagcatcagcagcctcacttctagaggag
caacagtcagcccagcttccccaggctcctccgcaaacttctgactctgttaaaaaagaa
cctgttcttgcccagcctgcagtcagcaactctggcactgcagcatctagtactagtctt
gtagcactttctgcagaggctaccccagccaccacgggggtccctgatgccaggacggag
gcagtaccacctgcttcctccttttctgtgcctgggcagactgctgtcacagcagctgct
atctcaagtgcaggccctgtggccgtcgaaacatcaagtacccccatagcctccagcacc
acgtccattgttgctcccggcccatctgcagaggcagcagcatttggtaccgtcacttct
ggctcatccgtctttgctcagcctcctgctgccagttctagctcagctttcaaccagctc
accaacaacacagccactgccccctctgccacgcccgtgtttgggcaagtggcagccagc
accgcaccaagtctgtttgggcagcagactggtagcacagccagcacagcagctgccaca
ccacaggtcagcagctcagggtttagcagcccagcttttggtaccacagccccaggggtc
tttggacagacaaccttcgggcaggcctcagtctttgggcagtcggcgagcagtgctgca
agtgtcttttccttcagtcagcctgggttcagttccgtgcctgccttcggtcagcctgct
tcctccactcccacatccaccagtggaagtgtctttggtgccgcctcaagtaccagtagc
tccagttccttctcatttggacagtcttctcccaacacaggaggggggctgtttggccaa
agcaacgctcctgcttttgggcagagtcctggctttggacagggaggctctgtctttggt
ggtacctcagctgccaccacaacagcagcaacctctgggttcagcttttgccaagcttca
ggttttgggtctagtaatactggttctgtgtttggtcaagcagccagtactggtggaata
gtctttggccagcaatcatcctcttccagtggtagcgtgtttgggtctggaaacactgga
agagggggaggtttcttcagtggccttggaggaaaacccagtcaggatgcagccaacaaa
aacccattcagctcggccagtgggggctttggatccacagctacctcaaatacctctaac
ctatttggaaacagtggggccaagacatttggtggatttgccagctcgtcgtttggagag
cagaaacccactggcactttcagctctggaggaggaagtgtggcatcccaaggctttggg
ttttcctctccaaacaaaacaggtggcttcggtgctgctccagtgtttggcagccctcct
acttttgggggatcccctgggtttggaggggtgccagcattcggttcagccccagccttt
acaagccctctgggctcgacgggaggcaaagtgttcggagagggcactgcagctgccagc
gcaggaggattcgggtttgggagcagcagcaacaccacatccttcggcacgctcgcgagt
cagaatgcccccactttcggatcactgtcccaacagacttctggttttgggacccagagt
agcggattctctggttttggatcaggcacaggagggttcagctttgggtcaaataactcg
tctgtccagggttttggtggctggcgaagctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (6)   
   KEGG DISEASE (2)   
   OMIM (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (92)   
   KEGG ORTHOLOGY (1)   
   RefGene (85)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (45)   
   RefSeq(nuc) (3)   
   GenBank (21)   
   EMBL (21)   
3D Structure (7)   
   PDB (7)   
Protein domain (4)   
   Pfam (4)   
All databases (167)   

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