KEGG   Homo sapiens (human): 80222
Entry
80222             CDS       T01001                                 
Symbol
TARS2, COXPD21, TARSL1, thrRS
Name
(RefSeq) threonyl-tRNA synthetase 2, mitochondrial
  KO
K01868  threonyl-tRNA synthetase [EC:6.1.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00891  Combined oxidative phosphorylation deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    80222 (TARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    80222 (TARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    80222 (TARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.3  threonine---tRNA ligase
     80222 (TARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (C/G)
   80222 (TARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    80222 (TARS2)
 Prokaryotic type
    80222 (TARS2)
SSDB
Motif
Pfam: tRNA-synt_2b HGTP_anticodon TGS tRNA_SAD
Other DBs
NCBI-GeneID: 80222
NCBI-ProteinID: NP_079426
OMIM: 612805
HGNC: 30740
Ensembl: ENSG00000143374
UniProt: Q9BW92
Position
1:150487419..150507602
AA seq 718 aa
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRT
IKISLPGGQKIDAVAWNTTPYQLARQISSTLADTAVAAQVNGEPYDLERPLETDSDLRFL
TFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLC
QGPHLRHTGQIGGLKLLSNSSSLWRSSGAPETLQRVSGISFPTTELLRVWEAWREEAELR
DHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYAHRGFSEVKTPTLFSTK
LWEQSGHWEHYQEDMFAVQPPGSDRPPSSQSDDSTRHITDTLALKPMNCPAHCLMFAHRP
RSWRELPLRLADFGALHRAEASGGLGGLTRLRCFQQDDAHIFCTTDQLEAEIQSCLDFLR
SVYAVLGFSFRLALSTRPSGFLGDPCLWDQAEQVLKQALKEFGEPWDLNSGDGAFYGPKI
DVHLHDALGRPHQCGTIQLDFQLPLRFDLQYKGQAGALERPVLIHRAVLGSVERLLGVLA
ESCGGKWPLWLSPFQVVVIPVGSEQEEYAKEAQQSLRAAGLVSDLDADSGLTLSRRIRRA
QLAHYNFQFVVGQKEQSKRTVNIRTRDNRRLGEWDLPEAVQRLVELQNTRVPNAEEIF
NT seq 2157 nt   +upstreamnt  +downstreamnt
atggccctgtatcagaggtggcggtgtctccggctccaaggtttacaggcttgcaggcta
cacacggcagttgtgtcgacccctccacgctggttggcagagcggcttggcctttttgag
gagctgtgggctgctcaggtaaagagattagcaagcatggcacagaaggaaccccggact
attaagatatcacttcctggaggccagaaaattgatgctgtggcatggaacacaaccccc
taccaactagcccggcagatcagttcaacactggcagatactgcagtggctgctcaagtg
aatggagaaccttatgatctggagcggcccttggagacagattctgacctcagatttctg
acattcgattccccagaggggaaagcagtgttctggcactccagcacccatgtcctgggg
gcagcagctgaacaattcctaggtgctgttctctgcagaggtccaagtacagaatatggc
ttttaccatgatttcttcctgggaaaggagaggacaatccggggctcagagctgcctgtt
ttggagcggatttgccaggaacttacagctgctgctcgacccttccggaggctagaggct
tcacgggatcagcttcgccagttgttcaaggataacccctttaagcttcacttgattgag
gagaaagtgacaggtccaacagcaacagtatatgggtgtggcacattggttgacctttgc
cagggcccccaccttcggcatactggacagattggaggactgaagctgctatcgaactca
tcatccttatggaggtcttcaggggccccagagacactgcagagagtgtcagggatttcc
ttccccacaacagaattgctgagggtctgggaagcatggagggaggaagcagaattgcgg
gaccaccggcgcattgggaaggaacaggagctcttcttcttccatgaactgagccctggg
agctgcttcttcctgccacgagggacaagggtgtataatgcactagtggcgtttatcagg
gctgagtatgcccatcgtggtttctccgaggtgaaaactcccacactgttttctacgaag
ctctgggaacagtcagggcactgggagcattatcaggaagacatgtttgccgtgcagccc
ccaggctctgacaggcctcccagctcccagagtgacgattctaccaggcatatcacagat
acactcgccctcaagcctatgaactgccctgcacactgcctgatgttcgcccaccggccc
agatcctggcgggaactgcccctgcgactagctgactttggggctctacaccgggccgaa
gcctctggtggtctggggggactgacccgactgcggtgcttccagcaggatgacgctcac
atcttctgtacaacagatcagctggaagcagagatccaaagctgtcttgatttcctccgt
tccgtctatgccgttcttggcttctccttccgcctggcactgtccacccggccatctggc
ttcctgggggacccttgcctttgggaccaggccgaacaggtccttaaacaggccctgaag
gaatttggagaaccctgggacctcaactctggagatggtgccttctatggacctaagatt
gacgtgcacctccacgatgccctgggccggccacatcagtgtgggacaattcagcttgac
ttccaactgcccctgagatttgacctccagtataaggggcaggcgggtgccctggagcgt
ccagtcctcattcaccgagcagtgctcggttctgtggaaagactgttgggagtgctggca
gaaagctgcggggggaaatggccactgtggctgtccccgttccaggtggtggtcatccct
gtggggagtgagcaagaggaatacgccaaagaggcacagcagagcctgcgggctgcagga
ctggtcagtgacctggatgcagactctggactgaccctcagccggagaatccgccgggcc
cagcttgcccactacaattttcagtttgtggttggccagaaagagcaaagtaagagaaca
gtgaacattcggactcgagataatcgtcgccttggggagtgggacttgcctgaggctgtg
cagcgactggtggagctacagaacacgagggtcccaaatgccgaagaaattttctga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (47)   
   RefSeq(nuc) (13)   
   GenBank (17)   
   EMBL (17)   
Protein domain (4)   
   Pfam (4)   
All databases (99)   

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