KEGG T01001: 80347

Homo sapiens (human): 80347

Entry

80347             CDS       T01001

Symbol

COASY, DPCK, NBIA6, NBP, PCH12, PPAT, UKR1, pOV-2

Name

(RefSeq) Coenzyme A synthase

K02318

phosphopantetheine adenylyltransferase / dephospho-CoA kinase [EC:2.7.7.3 2.7.1.24]

Organism

hsa Homo sapiens (human)

Pathway

hsa00770

Pantothenate and CoA biosynthesis

hsa01100

Metabolic pathways

hsa01240

Biosynthesis of cofactors

Module

hsa_M00120

Coenzyme A biosynthesis, pantothenate => CoA

Disease

H00833

Neurodegeneration with brain iron accumulation

H00897

Pontocerebellar hypoplasia

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    80347 (COASY)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    80347 (COASY)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.24  dephospho-CoA kinase
     80347 (COASY)
   2.7.7  Nucleotidyltransferases
    2.7.7.3  pantetheine-phosphate adenylyltransferase
     80347 (COASY)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    80347 (COASY)

SSDB

Motif

Pfam:

CoaE CTP_transf_like AAA_33 AAA_18 APS_kinase PRK

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Position

17:42562148..42566277

AA seq 564 aa
MAVFRSGLLVLTTPLASLAPRLASILTSAARLVNHTLYVHLQPGMSLEGPAQPQSSPVQA
TFEVLDFITHLYAGADVHRHLDVRILLTNIRTKSTFLPPLPTSVQNLAHPPEVVLTDFQT
LDGSQYNPVKQQLVRYATSCYSCCPRLASVLLYSDYGIGEVPVEPLDVPLPSTIRPASPV
AGSPKQPVRGYYRGAVGGTFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPEL
LQPYTERVEHLSEFLVDIKPSLTFDVIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAINR
FRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYERPELPTCLYV
IGLTGISGSGKSSIAQRLKGLGAFVIDSDHLGHRAYAPGGPAYQPVVEAFGTDILHKDGI
INRKVLGSRVFGNKKQLKILTDIMWPIIAKLAREEMDRAVAEGKRVCVIDAAVLLEAGWQ
NLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMSGQQLVEQSHVVLSTLWEPHI
TQRQVEKAWALLQKRIPKTHQALD

NT seq 1695 nt +upstreamnt +downstreamnt
atggccgtattccggtcgggtctcctggtgctgacgacgccgctggcctccctagcccct
cgcctggcctccatcctgacctcggcggcccggctggtgaatcacacactctatgttcac
ctgcagccgggcatgagcctggagggcccggctcagccccagtccagccccgtgcaggcc
acgtttgaggttcttgatttcatcacgcacctctatgctggcgccgacgtccacaggcac
ttggacgtcagaatcctactgaccaatatccgaaccaagagcacctttctccctcccctg
cccacctcagtccagaatctcgcccacccgccagaagtcgtgttgacagatttccagacc
ctggatggaagccagtacaacccggtcaaacagcagctagtgcgttacgccaccagctgt
tacagctgttgtccgcgactggcctcggtgctgctatactccgattatgggataggagaa
gtgcccgtggagcccctggatgtccccttaccctccacgatcaggccagcttcccccgtg
gccgggtctccaaagcagccggtgcgtggctactaccgtggcgctgtcggtggcacgttt
gaccgcctgcacaacgcccacaaggtgttgctcagtgtcgcgtgcatcctggcccaggag
cagcttgtggtgggagtagcagacaaagatctgttgaagagcaagttgctccctgagctg
ctccaaccttatacagaacgtgtggaacatctgagtgaattcctggtggacatcaagccc
tccttgacttttgatgtcatccccctgctggacccctatgggcccgctggctctgacccc
tccctggagttcctggtggtcagcgaggagacctatcgtggggggatggccatcaaccgc
ttccgccttgagaatgacctggaggaacttgctttgtaccagatccagctgctgaaggac
ctcagacatacagagaatgaagaggacaaagtcagctcctccagcttccgccagcgaatg
ttggggaacctgcttcggcctccatatgaaaggccagagctccccacatgtctctatgta
attgggctgactggcatcagtggctctgggaagagctcaatagctcagcgactgaagggc
ctgggggcgtttgtcattgacagtgaccacctgggtcatcgggcctatgccccaggtggc
cctgcctaccagcctgtggtggaggcctttggaacagatattctccataaagatggcatc
atcaacaggaaggtcctaggcagccgggtgtttgggaataagaagcagctgaagatactc
acggacattatgtggccaattatcgcaaagctggcccgagaggagatggatcgggctgtg
gctgagggaaagcgtgtgtgtgtgattgatgccgctgtgttgcttgaagccggctggcag
aacctggtccatgaggtgtggactgctgtcatcccagagactgaggctgtaagacgcatt
gtggagagggatggcctcagtgaagccgcggctcaaagccggctgcagagccagatgagc
gggcagcagcttgtggaacagagccacgtggtgctcagcaccttgtgggagccgcatatc
acccaacgccaggtggagaaagcctgggccctcttgcagaagcgcattcccaagactcat
caggccctcgactga

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