KEGG   Homo sapiens (human): 80746
Entry
80746             CDS       T01001                                 
Symbol
TSEN2, PCH2B, SEN2, SEN2L
Name
(RefSeq) tRNA splicing endonuclease subunit 2
  KO
K15322  tRNA-splicing endonuclease subunit Sen2 [EC:4.6.1.16]
Organism
hsa  Homo sapiens (human)
Disease
H00897  Pontocerebellar hypoplasia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    80746 (TSEN2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.16  tRNA-intron lyase
     80746 (TSEN2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  tRNA spricing factors
   tRNA splicing endonuclease complex
    80746 (TSEN2)
SSDB
Motif
Pfam: tRNA_int_endo tRNA_int_endo_N
Other DBs
NCBI-GeneID: 80746
NCBI-ProteinID: NP_001138864
OMIM: 608753
HGNC: 28422
Ensembl: ENSG00000154743
UniProt: Q8NCE0
Structure
Position
3:12480231..12539624
AA seq 465 aa
MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQL
YGKGYFGKGILSRSRPSFTISDPKLVAKWKDMKTNMPIITSKRYQHSVEWAAELMRRQGQ
DESTVRRILKDYTKPLEHPPVKRNEEAQVHDKLNSGMVSNMEGTAGGERPSVVNGDSGKS
GGVGDPREPLGCLQEGSGCHPTTESFEKSVREDASPLPHVCCCKQDALILQRGLHHEDGS
QHIGLLHPGDRGPDHEYVLVEEAECAMSEREAAPNEELVQRNRLICRRNPYRIFEYLQLS
LEEAFFLVYALGCLSIYYEKEPLTIVKLWKAFTVVQPTFRTTYMAYHYFRSKGWVPKVGL
KYGTDLLLYRKGPPFYHASYSVIIELVDDHFEGSLRRPLSWKSLAALSRVSVNVSKELML
CYLIKPSTMTDKEMESPECMKRIKVQEVILSRWVSSRERSDQDDL
NT seq 1398 nt   +upstreamnt  +downstreamnt
atggcagaagcagttttccatgccccaaagaggaaaagaagagtgtatgagacttacgag
tctccattgccaatcccttttggtcaggaccatggtcctctgaaagaattcaagatattc
cgtgctgaaatgattaacaacaatgtgattgtgaggaatgcggaggacattgagcagctc
tatgggaaaggttattttggaaaaggtattctttcaagaagccgtccaagcttcacaatt
tcagatcctaaactggttgctaaatggaaagatatgaagacaaacatgcctatcatcaca
tcaaagaggtatcagcatagtgttgagtgggcagcagagctgatgcgtagacaggggcag
gatgagagtacagtgcgcagaatcctcaaggattacacgaaaccgcttgagcatcctcct
gtgaaaaggaatgaagaggctcaagtgcatgacaagcttaactctggaatggtttccaac
atggaaggcacagcagggggagagagaccttctgtggtaaacggggactctggaaagtca
ggtggtgtgggtgatccccgtgagccattaggctgcctgcaggagggctctggctgccac
ccaacaacagagagctttgagaaaagcgtgcgagaggatgcctcacctctgccccatgtc
tgttgctgcaaacaagatgctctcatcctccagcgtggccttcatcatgaagacggcagc
cagcacatcggcctcctgcatcctggggacagagggcctgaccatgagtacgtgctggtc
gaggaagcggagtgtgccatgagcgagagggaggctgccccaaatgaggaattggtgcaa
agaaacaggttaatatgcagaagaaatccatataggatctttgagtatttgcaactcagc
ctagaagaggcctttttcttggtctatgctctgggatgtttaagtatttactatgagaag
gagcctttaacgatagtgaagctctggaaagctttcactgtagttcagcccacgttcaga
accacctacatggcctaccattactttcgaagcaagggctgggtgcccaaagtgggactc
aagtacgggacagatttactgctatatcggaaaggccctccattttaccatgcaagttat
tctgtcattatcgagctagttgatgaccattttgaaggctctctccgcaggcctctcagt
tggaagtccctggctgccttgagcagagtttccgttaatgtctctaaggaacttatgctg
tgctatttgattaaaccctctactatgactgacaaggaaatggagtcaccagaatgtatg
aaaaggattaaagttcaggaggtgattctgagtcgatgggtttcttcacgagagaggagt
gaccaagacgatctttaa

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (35)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (33)   
DNA sequence (113)   
   RefSeq(nuc) (77)   
   GenBank (18)   
   EMBL (18)   
3D Structure (5)   
   PDB (5)   
Protein domain (2)   
   Pfam (2)   
All databases (180)   

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