KEGG   Homo sapiens (human): 81704
Entry
81704             CDS       T01001                                 
Symbol
DOCK8, HEL-205, HIES2, MRD2, ZIR8
Name
(RefSeq) dedicator of cytokinesis 8
  KO
K21852  dedicator of cytokinesis protein 6/7/8
Organism
hsa  Homo sapiens (human)
Disease
H00773  Autosomal dominant intellectual developmental disorder
H01968  Hyper-IgE syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    81704 (DOCK8)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    81704 (DOCK8)
SSDB
Motif
Pfam: DOCK-C2 DHR-2_Lobe_A DHR-2_Lobe_C DOCK_C-D_N DHR-2_Lobe_B
Other DBs
NCBI-GeneID: 81704
NCBI-ProteinID: NP_982272
OMIM: 611432
HGNC: 19191
Ensembl: ENSG00000107099
UniProt: Q8NF50
Position
9:211257..465255
AA seq 2099 aa
MATLPSAERRAFALKINRYSSAEIRKQFTLPPNLGQYHRQSISTSGFPSLQLPQFYDPVE
PVDFEGLLMTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEGVELDPHVRD
CVQTYIREWLIVNRKNQGSPEICGFKKTGSRKDFHKTLPKQTFESETLECSEPAAQAGPR
HLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFA
LYPSVDEEDAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKIS
ENFHCDLNSDQFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIGD
CAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLERE
VTDVDSVVGRSSVGERRTLAQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLS
DEDLFKFLADYKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEMLPVKPFPENRTRP
HKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPV
IFGKSSGPEFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGA
SVETLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKG
VFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICL
NSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKD
QHGRNCLLASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARV
MSSSNPDLAGTHSAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHF
HEELALQMVVSTGMVRETVFKYAWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDI
TTIVNVVTSEIAALLVKPQKENEQAEKMNISLAFFLYDLLSLMDRGFVFNLIRHYCSQLS
AKLSNLPTLISMRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQD
QKIASMFDLTSEYRQQHFLTGLLFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDP
RCVKPEVKVKIAALYLPLVGIILDALPQLCDFTVADTRRYRTSGSDEEQEGAGAINQNVA
LAIAGNNFNLKTSGIVLSSLPYKQYNMLNADTTRNLMICFLWIMKNADQSLIRKWIADLP
STQLNRILDLLFICVLCFEYKGKQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEMMR
RRAPGNDRFPGLNENLRWKKEQTHWRQANEKLDKTKAELDQEALISGNLATEAHLIILDM
QENIIQASSALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEE
VEQCFDLCHQVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVG
RAPDFNEEHLRRSLRTILAYSEEDTAMQMTPFPTQVEELLCNLNSILYDTVKMREFQEDP
EMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSMLE
DHSYLPVGSVSFQNISSNVLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFS
TGGLYETVNEVYKLVIPILEAHREFRKLTLTHSKLQRAFDSIVNKDHKRMFGTYFRVGFF
GSKFGDLDEQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNK
AYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQYRRNTVLT
TMHAFPYIKTRISVIQKEEFVLTPIEVAIEDMKKKTLQLAVAINQEPPDAKMLQMVLQGS
VGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNKRLITADQR
EYQQELKKNYNKLKENLRPMIERKIPELYKPIFRVESQKRDSFHRSSFRKCETQLSQGS
NT seq 6300 nt   +upstreamnt  +downstreamnt
atggccactctgccgagcgcagagcgccgcgcgttcgcgctcaagatcaacaggtattct
tcagcggaaataaggaaacagtttactctcccaccaaaccttggccagtaccatcgacag
agcataagtacctctggcttcccctctcttcaactacctcagttttatgaccctgtggag
ccagtggactttgaaggacttctgatgacacacctgaacagcctggatgtgcagcttgcc
caggagctcggggacttcactgatgacgacttggacgtggtgttcacgccaaaggaatgt
aggactttgcagccctctttgccggaggaaggggttgaactggaccctcatgtcagggac
tgtgttcagacctacatccgtgagtggctaatcgtgaaccggaaaaaccaaggaagtcca
gaaatctgtggctttaaaaagactggatctcgaaaagattttcacaagacgcttccgaaa
cagacgtttgagtcggaaaccttggagtgcagtgaacccgctgctcaggcaggcccccgc
cacttaaacgtgctgtgcgacgtgtctgggaaaggccccgtcactgcctgtgactttgac
ctccgcagcctgcagcctgacaagcggctagaaaacctcctgcagcaagtgagtgccgag
gactttgagaagcagaacgaggaggcccggaggaccaataggcaggccgagctctttgcc
ctttacccatcagtggacgaggaggatgctgtggaaatacgtccagtaccagaatgtccc
aaggaacacctgggcaacagaatattggtcaagttgctgaccttgaagttcgagattgaa
attgagcccctgtttgccagcattgccctctacgatgttaaagaaaggaaaaagatctca
gaaaattttcactgtgacctgaactctgaccagttcaaaggatttctgcgagctcacacg
ccttcagtggccgcatcaagtcaggcgagatctgcagtcttctcagtcacctacccgtcc
tcagacatctacctggtagtcaagattgaaaaagtcctgcagcagggagagattggagac
tgtgcagagccctacacggttatcaaagaaagtgatggtggaaagagtaaagaaaagatt
gaaaaactaaaactccaagctgaatccttctgccagcgtttggggaaataccggatgccc
tttgcctgggcacccataagcttatcaagcttcttcaatgtctccacccttgagagggag
gtaactgatgtggactctgtggttgggagaagctcagtgggtgaacggaggacattggcc
caatctagaaggctttctgaaagagccctctccttggaggaaaatggggttggatccaac
ttcaaaacctccactctgagcgttagcagctttttcaagcaggaaggagatcgccttagc
gatgaagacttattcaagtttttagctgactacaaaagatcatcatccttacagagacga
gtcaagtcaattccaggcttgctaagactggagatttctacagctccagagatcatcaat
tgctgtctgactcctgaaatgctgcccgtgaaaccctttcctgaaaaccggacacgcccg
cacaaagagattttggaatttccaacacgagaagtatatgtccctcacactgtgtacaga
aaccttctctatgtctacccacagaggctgaactttgtaaacaaactagcatcagcccgg
aacattacaataaagatccagtttatgtgtggagaagatgctagcaatgcgatgccggtc
atctttggaaaatccagcgggcctgaatttctgcaggaagtgtacacagctgttacatac
cataataagtctcctgacttttatgaagaagtgaaaattaagctccccgctaagctcaca
gtaaatcaccacctcctgttcaccttctaccatatcagctgtcagcagaagcaaggagcc
tccgtggaaactctcctgggatattcatggctgccaattctcttaaatgaacgtcttcaa
actggatcctactgtctcccagttgccttggaaaaattgccacccaactactccatgcat
tctgctgagaaagtcccattacagaatcctcccattaagtgggctgaaggacataaggga
gtatttaatattgaagtgcaagctgtttcttctgtacacacccaggacaaccacctggag
aagttcttcaccctctgccactccctggagagccaggtgaccttccccatccgcgtgctg
gatcagaaaatcagcgagatggcgctggagcatgagctgaagctcagcatcatctgcctg
aactcctcccgcctggagccgctcgtgctcttcctgcacctggtgctggacaagctcttc
cagctgtccgtgcagcccatggtcatcgctggccagacagccaacttctcccagtttgcc
ttcgagtccgtggtggccatcgccaacagtctgcacaacagcaaggacctgagcaaggac
cagcatgggaggaactgcctgctggcttcctacgtgcactacgtcttccgcctgccagag
gtgcaaagggatgtgcccaagtcaggcgctcccactgccctcctagaccctcggagctac
cacacgtatggccgcacatcagctgctgctgtgagttcaaagctgctgcaggcccgggtg
atgagcagcagtaacccagacctcgcggggacacactccgcagcagacgaggaagtgaag
aacatcatgtcttcaaagatcgccgatcgcaactgcagccgaatgtcttactattgctct
ggcagtagtgatgctccaagttcacctgcagccccaaggccagccagcaaaaagcatttc
catgaggagcttgcccttcagatggtggtcagcaccggaatggtgagagaaacagtcttc
aagtatgcctggttcttctttgagcttctggtgaaaagcatggcccagcacgtacataac
atggacaaacgggacagttttcggaggactcgtttttctgaccgtttcatggatgacata
actactattgttaatgtggtcacctcggaaattgcagcccttttagtaaaaccacagaag
gaaaatgaacaggcggaaaagatgaacatcagcctggctttcttcttgtatgaccttctc
tccctcatggatcggggctttgtgtttaacctcatcagacattattgcagccagctgtca
gccaagctcagtaaccttccaacgctcatttccatgaggctagagttcctgagaatcctc
tgtagccatgagcattacctcaatctgaaccttttttttatgaatgctgatactgctcca
acatctccttgtccttccatatcttcccagaactcaagctcctgctccagcttccaggac
cagaagatcgccagcatgttcgatctgacttccgagtaccgccagcagcacttcctcacc
gggctcctcttcacagaactggctgctgccctggatgccgaaggggaaggaatcagcaaa
gtacaaaggaaagctgtcagtgcaattcacagcctgctaagttctcacgacctggaccca
cgctgtgtcaaaccagaggtgaaggtcaaaatcgccgccctttacctacctttagttggc
atcattttggatgctttgccacagctctgtgactttacagttgcagatactcgcagatac
cgcaccagtggctcggatgaagaacaagaaggagccggtgccattaaccagaatgtggct
ctggccatagcagggaataatttcaatttgaaaacaagtggaatagtgctgtcttccttg
ccctataagcagtacaacatgctgaacgcggacactactcgcaacctcatgatctgcttc
ctctggatcatgaaaaatgctgatcagagcctcattaggaagtggattgctgacctgcca
tcaacgcagctcaacaggattttagatctacttttcatctgtgtgttatgttttgagtat
aagggaaaacagagttctgacaaagtcagtacccaagtcctgcagaagtcaagggatgtc
aaggcccggctggaagaggctttgctccgtggggaaggggccagaggggagatgatgcgc
cgccgggctccagggaacgaccgatttccaggcctaaatgaaaatttgagatggaagaaa
gagcagacacattggcggcaagctaatgagaagctagataaaacaaaggccgagttagat
caagaagccttgatcagtggcaatctggctacagaagcacatttaatcatcctggatatg
caggaaaacattatccaggcgagctcggctctggactgtaaagacagcctgctgggaggt
gttctgagggtgctggtgaattctctgaactgtgatcagagtaccacctacctgactcac
tgctttgcaacactccgtgctctcatcgccaagtttggagacttactctttgaagaggag
gtggaacagtgtttcgacctatgtcaccaagtcctgcaccactgcagcagcagcatggat
gtcacccggagccaagcctgtgccaccctttacctcctcatgaggttcagttttggagcc
accagtaattttgcaagagtaaagatgcaagtaaccatgtccctggcatctttggtggga
agagcaccagactttaatgaagagcacctgagaagatccttgaggacaattttggcctat
tcagaagaggacacagccatgcagatgactccttttcccacccaggtggaggaacttctc
tgtaatctgaatagcatcttatatgacacagtgaaaatgagggaatttcaggaagatcct
gagatgcttatggatctcatgtacagaattgccaagagttaccaggcatctcctgatctg
cggctgacctggctccagaacatggcagagaaacacaccaagaagaagtgctacacggag
gctgccatgtgcctggtgcacgccgctgcgttagtggctgagtatctgagcatgctggag
gaccacagctacctgcccgtgggcagtgtcagcttccagaatatttcttccaatgtgctg
gaggagtctgtggtctctgaggacaccctgtcacctgacgaggatggggtgtgcgcaggc
cagtacttcaccgagagtggcctggtaggcctcctggagcaggccgcggagctcttcagc
acgggaggcttatatgagacagttaatgaggtctacaagctggtcatccccatcctagaa
gcgcatcgagaattccggaagctgacactcactcacagcaagctgcagagagccttcgac
agcatcgttaacaaggatcataagagaatgtttggaacctacttccgagttggtttcttt
ggatccaaatttggggatttggatgaacaggagtttgtctacaaagagcctgcaattacc
aagcttcctgagatctcacatagactagaggcattttatggtcaatgttttggtgcagaa
tttgtggaagtgattaaagactccactcctgtggacaaaaccaagttggatcctaacaag
gcctacatacagatcacttttgtggagccctactttgatgagtatgagatgaaagacagg
gtcacatactttgagaagaatttcaacctccggaggttcatgtacaccaccccgttcacc
ctggaggggcggcctcggggagagctgcatgagcagtacagaaggaacacagtcctgacc
actatgcacgccttcccctacatcaagaccaggatcagcgtcatccagaaggaggagttt
gttttgacaccgattgaagttgccattgaagacatgaagaagaagaccctgcagttagca
gttgccattaaccaggagccgcctgatgcaaagatgcttcagatggtgctgcaaggctct
gtgggagctactgtaaatcagggaccactggaagtagcccaagtgtttttggctgaaatt
cctgctgatccaaaactctatcgacatcacaacaagttgaggttatgctttaaggaattc
atcatgagatgtggtgaagctgtagagaaaaacaagcgtctcatcacggcagaccagagg
gaatatcagcaggaactcaaaaagaactataacaagctaaaagagaacctcaggccaatg
atcgagcggaaaattccagaactgtacaagccaatattcagagttgagagtcaaaagagg
gactccttccacagatctagtttcaggaaatgtgaaacccagttgtcacagggcagctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (19)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (17)   
DNA sequence (73)   
   RefSeq(nuc) (17)   
   GenBank (28)   
   EMBL (28)   
Protein domain (5)   
   Pfam (5)   
All databases (131)   

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