KEGG   Homo sapiens (human): 81858
Entry
81858             CDS       T01001                                 
Symbol
SHARPIN, SIPL1
Name
(RefSeq) SHANK associated RH domain interactor
  KO
K20894  shank-associated RH domain-interacting protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04217  Necroptosis
hsa04621  NOD-like receptor signaling pathway
hsa05131  Shigellosis
Network
nt06516  TNF signaling
  Element
N01545  Regulation of TNF-NFKB signaling pathway, LUBAC-mediated linear ubiquitination
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    81858 (SHARPIN)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    81858 (SHARPIN)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    81858 (SHARPIN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    81858 (SHARPIN)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   LUBAC complex
    81858 (SHARPIN)
SSDB
Motif
Pfam: Sharpin_PH zf-RanBP ubiquitin
Other DBs
NCBI-GeneID: 81858
NCBI-ProteinID: NP_112236
OMIM: 611885
HGNC: 25321
Ensembl: ENSG00000179526
UniProt: Q9H0F6 Q6PJD5
Structure
Position
8:complement(144098637..144103773)
AA seq 387 aa
MAPPAGGAAAAASDLGSAAVLLAVHAAVRPLGAGPDAEAQLRRLQLSADPERPGRFRLEL
LGAGPGAVNLEWPLESVSYTIRGPTQHELQPPPGGPGTLSLHFLNPQEAQRWAVLVRGAT
VEGQNGSKSNSPPALGPEACPVSLPSPPEASTLKGPPPEADLPRSPGNLTEREELAGSLA
RAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHV
ALQVHPHCTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLL
SAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGPQPAASSLPSPLQPSWSCPSCTFI
NAPDRPGCEMCSTQRPCTWDPLAAAST
NT seq 1164 nt   +upstreamnt  +downstreamnt
atggcgccgccagcgggcggggcggcggcggcggcctcggacttgggctccgccgcagtg
ctcttggctgtgcacgccgcggtgaggccgctgggcgccgggccagacgccgaggcacag
ctgcggaggctgcagctgagcgcggaccctgagcggcctgggcgcttccggctggagctg
ctgggcgcgggacctggggcggttaatttggagtggcccctggagtcagtttcctacacc
atccgaggccccacccagcacgagctacagcctccaccaggagggcctggaaccctcagc
ctgcacttcctcaaccctcaggaagctcagcggtgggcagtcctagtccgaggtgccacc
gtggaaggacagaatggcagcaagagcaactcaccaccagccttgggcccagaagcatgc
cctgtctccctgcccagtcccccggaagcctccacactcaagggccctccacctgaggca
gatcttcctaggagccctggaaacttgacggagagagaagagctggcagggagcctggcc
cgggctattgcaggtggagacgagaagggggcagcccaagtggcagccgtcctggcccag
catcgtgtggccctgagtgttcagcttcaggaggcctgcttcccacctggccccatcagg
ctgcaggtcacacttgaagacgctgcctctgccgcatccgccgcgtcctctgcacacgtt
gccctgcaggtccacccccactgcactgttgcagctctccaggagcaggtgttctcagag
ctcggtttcccgccagccgtgcaacgctgggtcatcggacggtgcctgtgtgtgcctgag
cgcagccttgcctcttacggggttcggcaggatggggaccctgctttcctctacttgctg
tcagctcctcgagaagccccagccacaggacctagccctcagcacccccagaagatggac
ggggaacttggacgcttgtttcccccatcattggggctacccccaggcccccagccagct
gcctccagcctgcccagtccactccagcccagctggtcctgtccttcctgcaccttcatc
aatgccccagaccgccctggctgtgagatgtgtagcacccagaggccctgcacttgggac
ccccttgctgcagcttccacctag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   RefGene (23)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (34)   
   RefSeq(nuc) (8)   
   GenBank (13)   
   EMBL (13)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (94)   

Download RDF
DBGET integrated database retrieval system