KEGG   Homo sapiens (human): 8242
Entry
8242              CDS       T01001                                 
Symbol
KDM5C, DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169
Name
(RefSeq) lysine demethylase 5C
  KO
K11446  [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67]
Organism
hsa  Homo sapiens (human)
Disease
H00658  X-linked syndromic intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    8242 (KDM5C)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    8242 (KDM5C)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.67  [histone H3]-trimethyl-L-lysine4 demethylase
     8242 (KDM5C)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     8242 (KDM5C)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    8242 (KDM5C)
SSDB
Motif
Pfam: PLU-1 JmjC KDM5_C-hel ARID zf-C5HC2 JmjN PHD ASH2L-like_WH
Other DBs
NCBI-GeneID: 8242
NCBI-ProteinID: NP_004178
OMIM: 314690
HGNC: 11114
Ensembl: ENSG00000126012
UniProt: P41229
Structure
Position
X:complement(53176277..53225207)
AA seq 1560 aa
MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV
DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV
EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP
FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG
AGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSH
SPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPE
IPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTEL
VEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMP
VLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSL
AAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRA
YHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDL
NLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALA
CYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVA
LEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGP
HRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGL
LQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASV
APSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQ
ALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHS
WREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDL
RDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGAL
QCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILA
LLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPR
PEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSL
LPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLEL
EKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEE
ETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL
NT seq 4683 nt   +upstreamnt  +downstreamnt
atggagccggggtccgacgatttcctaccgccaccggagtgcccggtgttcgagcctagc
tgggccgagttccgagaccctcttggctacatcgcgaaaatcaggcccatcgcagagaaa
tcgggcatttgcaagatccgcccacccgcggactggcagccaccctttgctgtggaagtg
gacaacttcaggtttaccccccgaatccagaggctgaatgagctagaggcccagacgaga
gtgaaactgaactacttggaccagattgccaaattctgggaaatccagggctcctcctta
aagattcccaatgtagaacggcggatcttggacctctacagtctcagcaaaattgtggtg
gaggaaggtggttatgaagctatctgcaaggaccgtcggtgggctcgggtagcccagcgc
ctcaactatccaccaggcaaaaatattggctccttgctacgctcccactacgaacgcatt
gtttatccctatgaaatgtaccagtctggagccaaccttgtgcagtgtaacacacgtcca
tttgataatgaggagaaggacaaggaatacaaaccccacagcatccccctacgacagtct
gtgcagccttccaagttcaacagctatggccggcgggccaagagactgcagcctgatccg
gaacccacagaggaagacattgagaagaatccagagctgaaaaagctacagatctatggg
gcaggccccaagatgatgggcctgggcctcatggccaaagacaagactctgcggaagaaa
gataaggaggggcctgagtgtccccccacagtagtggtgaaggaggagttaggtggggat
gtgaaggtggagtcaacatcgcctaagaccttcctggagagcaaggaggagctgagtcac
agcccagaaccctgcaccaagatgaccatgaggctacggaggaaccacagcaatgcccag
tttattgagtcatatgtctgccggatgtgttctcgaggggatgaggatgacaagctcctg
ctgtgtgatggctgtgatgacaactaccacatcttctgcctgctgcctcctctgcctgag
atccccaagggtgtctggcggtgcccaaagtgtgtcatggcggagtgtaagcggccccca
gaagcctttggctttgagcaggctacccgggaatacactctgcagagctttggcgagatg
gccgactcctttaaagctgactacttcaacatgcccgtgcatatggtgcccacagaactt
gtggagaaggagttctggaggctggtaaatagcattgaggaagatgtgactgttgagtat
ggagctgacatccattccaaagaatttggcagcggtttccctgtcagtgacagtaaacgg
cacctaacccccgaagaggaggagtatgctaccagtggttggaacctaaatgtgatgccg
gtgttggaacagtctgtactgtgccacatcaatgcagatatctctggcatgaaggtgccc
tggctctacgtgggcatggtcttctcagccttttgctggcatattgaggatcactggagt
tactccattaactacctccactggggtgagccgaagacctggtatggggtgccctcactt
gcagcagaacatttggaagaagtgatgaagaagctgacacctgaactatttgatagccag
cctgacctcctgcaccaacttgtcaccctcatgaatcccaacaccctcatgtcccatggt
gtgccagttgtccgcacaaaccagtgtgcaggagagtttgtcatcaccttcccccgtgct
taccacagcggcttcaaccaaggctacaactttgccgaggctgtcaacttttgcactgct
gactggttgcctgctgggcgccagtgcattgagcactaccgccggctccggagatactgc
gtcttctcccatgaggagcttatctgcaagatggctgcctgcccagagaagctagacctg
aacctggcggcagctgtgcataaggagatgttcatcatggtgcaagaagagcggcgtcta
cgaaaggccctgctggagaagggtatcacagaggctgagcgagaggctttcgagctgctc
ccagatgatgagcgccagtgtatcaagtgcaagactacgtgtttcctgtcagccctggcc
tgctacgactgcccagacggccttgtctgcctttcccacatcaatgatctctgcaagtgc
tccagtagccggcagtacctgcggtatcggtataccttggatgagcttcctgccatgctg
cataagctgaaggttcgggctgagtcctttgacacctgggccaacaaagtgcgagtggcc
ctggaggtggaggatgggcggaagcgcagccttgaagaactgagggcactagagtctgaa
gcccgtgagcggaggtttcctaatagtgagctgctgcagcaactaaagaactgcctgagt
gaggcagaggcttgcgtgtcccgagctctgggactggtcagcggccaggaagctggcccc
cacagggtggctggtctacagatgaccctgactgagctccgggcctttctggaccagatg
aacaacctgccttgcgccatgcaccagattggggatgtcaagggtgttctggaacaggtg
gaggcctaccaggctgaggctcgtgaggccctggcctcactgccctccagtccagggcta
ctgcagtccctgttggagagggggcggcagctgggggtggaggtgcctgaggcccagcag
ctccagcggcaggtggaacaggcgcgatggctggatgaggtgaaacgcacactggccccc
tcagcccgaaggggcaccttggctgtcatgcgaggactgttggtcgcgggtgccagtgta
gcccctagccctgctgtggataaagcccaggccgagctgcaggaactgctgaccattgct
gaacgctgggaggagaaagcccacctctgcctggaggccaggcagaagcatccaccagcc
acacttgaggccataatccgtgaagcggaaaacatccctgttcacctgcccaacatccag
gctctcaaggaggctcttgctaaggcccgggcctggattgctgatgttgatgagatccaa
aatggtgaccactacccctgcctggatgacttggagggcctagtagctgtgggccgggac
ctacctgtggggctggaggagctgagacagctagagctacaggtactgacagcgcactcc
tggagggagaaggcctccaagaccttcctcaagaaaaattcttgctacacgctgctggag
gttctctgcccatgtgcagatgccggctcagacagcaccaagcgcagccggtggatggag
aaggagctggggttgtacaaatctgacacagagctgctggggctgtctgcgcaggacctc
agggacccaggctctgtgatcgtggccttcaaggagggggaacagaaggagaaggagggt
atcctgcagctgcgtcgcaccaattcggccaagcccagtccactggcatcatcgagcacg
gcctcctctacaacctctatctgtgtgtgtgggcaggtgctggctggggcgggagctctg
cagtgtgacctgtgtcaggactggttccatgggcggtgtgtgtcagtgcctcgcctcctc
agctctccgaggcccaatcccacctcatccccactgctggcctggtgggaatgggacacc
aaattcctgtgtccactgtgtatgcgctcaaggcgcccgcgcctggagaccatcctggca
ctgctggtagccctgcagagactgcctgtgcggctgcccgagggcgaggccctgcagtgc
ctcacagagagggccatcagctggcaaggccgcgccaggcaggctctggcctctgaagat
gtgactgctcttttgggacggctggctgagctccgccaacggctacaggctgaacctaga
cctgaggagcctcctaactaccctgcagcccctgcttctgaccccctcagagagggcagt
ggcaaggatatgcctaaggtccagggcttactggagaatggagacagtgtgaccagtcct
gagaaggtagccccggaggagggctcaggtaagagagatctggagctgctgtcctcgctg
ttgccacagttgactggccctgtgttggaactgcctgaggcaacccgggcccccttggag
gagctcatgatggagggggacctgctcgaggtgaccctggatgagaaccacagcatatgg
cagctgctgcaggctggacagcccccagacctggagaggatccgcacacttctggagctg
gagaaggcagagcgtcacgggagtcgggctcggggccgggccctggagaggcggcggcgg
cggaaggtggatcggggtggggagggcgatgacccagcccgagaggagctagagccaaag
agggtacggagctcagggccagaggctgaggaggtccaggaggaggaagagctggaggag
gagactgggggtgagggcccccctgcacccatccccaccactggcagccccagcacccag
gagaaccagaatggcttggaaccggcggaagggaccacttcaggcccctcggcccctttc
tccactctgactccccggctgcatctgccctgcccacagcagccgcctcagcaacagttg
tga

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Ontology (4)   
   KEGG BRITE (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (31)   
   RefSeq(nuc) (11)   
   GenBank (10)   
   EMBL (10)   
3D Structure (2)   
   PDB (2)   
Protein domain (8)   
   Pfam (8)   
All databases (77)   

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