KEGG   Homo sapiens (human): 8284
Entry
8284              CDS       T01001                                 
Symbol
KDM5D, HY, HYA, JARID1D, SMCY
Name
(RefSeq) lysine demethylase 5D
  KO
K11446  [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    8284 (KDM5D)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    8284 (KDM5D)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.67  [histone H3]-trimethyl-L-lysine4 demethylase
     8284 (KDM5D)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     8284 (KDM5D)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    8284 (KDM5D)
SSDB
Motif
Pfam: PLU-1 JmjC KDM5_C-hel ARID JmjN zf-C5HC2 PHD ASH2L-like_WH
Other DBs
NCBI-GeneID: 8284
NCBI-ProteinID: NP_004644
OMIM: 426000
HGNC: 11115
Ensembl: ENSG00000012817
UniProt: Q9BY66 A0A384MR42
Structure
Position
Y:complement(19703865..19744726)
AA seq 1539 aa
MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV
DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI
EEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHP
FDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYG
PGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTM
QLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK
CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS
SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHI
NADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMK
MLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYN
FAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEM
FIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVC
LSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRS
FEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTEL
RVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGV
EVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAEL
QELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWI
ADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKN
SCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEG
EQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQC
VSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLP
EGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATAC
DPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIR
APLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALE
RRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDH
SPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL
NT seq 4620 nt   +upstreamnt  +downstreamnt
atggaaccggggtgtgacgagttcctgccgccaccggagtgcccggtttttgagcctagc
tgggctgaattccaagacccgcttggctacattgcgaaaataaggcccatagcagagaag
tctggcatctgcaaaatccgcccacccgcggattggcagcctccttttgcagtagaagtt
gacaatttcagatttactcctcgcgtccaaaggctaaatgaactggaggcccaaactaga
gtgaaattgaactatttggatcagattgcaaaattctgggaaattcaaggctcctcttta
aagattcccaatgtggagcggaagatcttggacctctacagccttagtaagattgtgatt
gaggaaggtggctatgaagccatctgcaaggatcgtcggtgggctcgagttgcccagcgt
ctccactacccaccaggcaaaaacattggctccctgctacgatcacattacgaacgcatt
atttacccctatgaaatgtttcagtctggagccaaccatgtgcaatgtaacacacacccg
tttgacaatgaggtaaaagataaggaatacaagccccacagcatcccccttagacagtct
gtgcagccttcaaagttcagcagctacagtcgacgggcaaaaaggctacagcctgatcca
gagcctacagaggaggacattgagaagcatccagagctaaagaagttacagatatatggg
ccaggtcccaaaatgatgggcttgggccttatggctaaggataaggataagactgtgcat
aagaaagtcacatgccccccaactgttacggtgaaggatgagcaaagtggaggtgggaac
gtgtcatcaacattgctcaagcagcacttgagcctagagccctgcactaagacaaccatg
caacttcgaaagaatcacagcagtgcccagtttattgactcatatatttgccaagtatgc
tcccgtggggatgaagatgataagcttcttttctgtgatggctgtgatgacaattaccac
atcttctgcttgttaccaccccttcctgaaatccccagaggcatctggaggtgcccaaaa
tgtatcttggcggagtgtaaacagcctcctgaagcttttggatttgaacaggctacccag
gagtacagtttgcagagttttggtgaaatggctgattccttcaagtccgactacttcaac
atgcctgtacatatggtgcctacagaacttgtagagaaggaattctggaggctggtgagc
agcattgaggaagacgtgacagttgaatatggagctgatattcattccaaagaatttggc
agtggctttcctgtcagcaatagcaaacaaaacttatctcctgaggagaaggagtatgcg
accagtggttggaacctgaatgtgatgccagtgctagatcagtctgttctctgtcacatc
aatgcagacatctcaggcatgaaggtgccctggctgtacgtgggcatggttttctcagca
ttttgttggcatattgaggatcactggagttactctattaactatctgcattggggtgag
ccgaagacctggtatggtgtaccctccctggcagcagagcatttggaggaggtgatgaag
atgctgacacctgagctgtttgatagccagcctgatctcctacaccagcttgtcactctc
atgaatcccaacactttgatgtcccatggtgtgccagttgtccgcacaaaccagtgtgca
ggggagtttgtcatcacttttcctcgtgcttaccacagtggttttaaccaaggctacaat
tttgctgaagctgtcaacttttgtactgctgactggctacctgctggacgccagtgcatt
gaacactaccgccggctccggcgctattgtgtcttctcccacgaggagctcatctgcaag
atggctgccttcccagagacgttggatctcaatctagcagtagctgtgcacaaggagatg
ttcattatggttcaggaggagcgacgtctacgaaaggcccttttggagaagggcgtcacg
gaggctgagcgagaggcttttgagctgctcccagatgatgaacgccagtgcatcaagtgc
aagaccacgtgcttcttgtcagccctggcctgctacgactgcccagatggccttgtatgc
ctttcccacatcaatgacctctgcaagtgctctagtagccgacagtacctccggtatcgg
tacaccttggatgagctccccaccatgctgcataaactgaagattcgggctgagtctttt
gacacctgggccaacaaagtgcgagtggccttggaggtggaggatggccgtaaacgcagc
tttgaagagctaagggcactggagtctgaggctcgtgagaggaggtttcctaatagtgag
ctgcttcagcgactgaagaactgcctgagtgaggtggaggcttgtattgctcaagtcctg
gggctggtcagtggtcaggtggccaggatggacactccacagctgaccttgactgaactc
cgggtccttcttgagcagatgggcagcctgccctgtgccatgcatcagattggggatgtc
aaggatgtcctggaacaggtggaggcctatcaagctgaggctcgtgaggctctggccaca
ctgccctctagtccagggctattgcggtccctgttggagagggggcagcagctgggtgta
gaggtgcctgaagcccatcagcttcagcagcaggtggagcaggcgcaatggctagatgaa
gtgaagcaggccctggccccttctgctcacaggggctctctggtcatcatgcaggggctt
ttggttatgggtgccaagatagcctccagcccttctgtggacaaggcccgggctgagctg
caagaactactgaccattgcagagcgctgggaagaaaaggctcatttctgcctggaggcc
aggcagaagcatccaccagccacattggaagccataattcgtgagacagaaaacatccct
gttcacctgcctaacatccaggctctcaaagaagctctgactaaggcacaagcttggatt
gctgatgtggatgagatccaaaatggtgaccactacccctgtctagatgacttggagggc
ctggtggctgtgggccgggacctgcctgtggggctggaagagctgagacagctagagctg
caggtattgacagcacattcctggagagagaaggcctccaagacctttctcaagaagaat
tcttgctacacactgcttgaggtgctttgcccgtgtgcagacgctggctcagacagcacc
aagcgtagccggtggatggagaaggcgctggggttgtaccagtgtgacacagagctgctg
gggctgtctgcacaggacctcagagacccaggctctgtgattgtggccttcaaggaaggg
gaacagaaggagaaggagggtatcctgcagctgcgtcgcaccaactcagccaagcccagt
ccactggcaccatccctcatggcctcttctccgacttctatctgtgtgtgtgggcaggtg
ccagctggggtgggagttctgcagtgtgacctgtgtcaggactggttccatgggcagtgt
gtgtcagtgccccatctcctcacctctccaaagcccagtctcacttcatctccactgcta
gcctggtgggaatgggacacaaaattcctgtgtccactgtgtatgcgctcacgacggcca
cgcctagagacaatcctagccttgctggttgccctgcagaggctgcccgtgcggctgcct
gagggtgaggcccttcagtgtctcacagagagggccattggctggcaagaccgtgccaga
aaggctctggcctctgaagatgtgactgctctgttgcgacagctggctgagcttcgccaa
cagctacaggccaaacccagaccagaggaggcctcagtctacacttcagccactgcctgt
gaccctatcagagaaggcagtggcaacaatatttctaaggtccaagggctgctggagaat
ggagacagtgtgaccagtcctgagaacatggctccaggaaagggctctgacctggagcta
ctgtcctcactgttgccgcagttgactggccctgtgttggagctgcctgaggcaatccgg
gctcccctggaggagctcatgatggaaggggacctgcttgaggtgaccctggatgagaac
cacagcatctggcagctgctgcaggctggacagcctccagacctggacagaattcgcaca
cttctggagctggaaaaatttgaacatcaagggagtcggacaaggagccgggctctggag
aggcgacggcggcggcagaaggtggatcagggtagaaacgttgagaatcttgttcaacag
gagcttcagtcaaaaagggctcggagctcagggattatgtctcaggtgggccgagaagaa
gaacattatcaggagaaagcagaccgtgaaaatatgttcctgacaccttccacagaccac
agccctttcttgaaaggaaaccaaaatagcttacaacacaaggattcaggctcttcagct
gcttgtccttctttaatgcctttgctacaactctcctactctgatgagcaacagttgtga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Disease (2)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (28)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (25)   
DNA sequence (59)   
   RefSeq(nuc) (25)   
   GenBank (17)   
   EMBL (17)   
3D Structure (2)   
   PDB (2)   
Protein domain (8)   
   Pfam (8)   
All databases (131)   

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