KEGG   Homo sapiens (human): 835
Entry
835               CDS       T01001                                 
Symbol
CASP2, CASP-2, ICH1, MRT80, NEDD-2, NEDD2, PPP1R57
Name
(RefSeq) caspase 2
  KO
K02186  caspase 2 [EC:3.4.22.55]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04210  Apoptosis
Disease
H00768  Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    835 (CASP2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    835 (CASP2)
   01002 Peptidases and inhibitors [BR:hsa01002]
    835 (CASP2)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.55  caspase-2
     835 (CASP2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     835 (CASP2)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C14: caspase family
   835 (CASP2)
SSDB
Motif
Pfam: Peptidase_C14 CARD CARD_2
Other DBs
NCBI-GeneID: 835
NCBI-ProteinID: NP_116764
OMIM: 600639
HGNC: 1503
Ensembl: ENSG00000106144
UniProt: P42575 A0A0S2Z3H1
Structure
Position
7:143288351..143307696
AA seq 452 aa
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
NT seq 1359 nt   +upstreamnt  +downstreamnt
atggcggcgccgagcgcggggtcttggtccaccttccagcacaaggagctgatggccgct
gacaggggacgcaggatattgggagtgtgtggcatgcatcctcatcatcaggaaactcta
aaaaagaaccgagtggtgctagccaaacagctgttgttgagcgaattgttagaacatctt
ctggagaaggacatcatcaccttggaaatgagggagctcatccaggccaaagtgggcagt
ttcagccagaatgtggaactcctcaacttgctgcctaagaggggtccccaagcttttgat
gccttctgtgaagcactgagggagaccaagcaaggccacctggaggatatgttgctcacc
accctttctgggcttcagcatgtactcccaccgttgagctgtgactacgacttgagtctc
ccttttccggtgtgtgagtcctgtcccctttacaagaagctccgcctgtcgacagatact
gtggaacactccctagacaataaagatggtcctgtctgccttcaggtgaagccttgcact
cctgaattttatcaaacacacttccagctggcatataggttgcagtctcggcctcgtggc
ctagcactggtgttgagcaatgtgcacttcactggagagaaagaactggaatttcgctct
ggaggggatgtggaccacagtactctagtcaccctcttcaagcttttgggctatgacgtc
catgttctatgtgaccagactgcacaggaaatgcaagagaaactgcagaattttgcacag
ttacctgcacaccgagtcacggactcctgcatcgtggcactcctctcgcatggtgtggag
ggcgccatctatggtgtggatgggaaactgctccagctccaagaggtttttcagctcttt
gacaacgccaactgcccaagcctacagaacaaaccaaaaatgttcttcatccaggcctgc
cgtggagatgagactgatcgtggggttgaccaacaagatggaaagaaccacgcaggatcc
cctgggtgcgaggagagtgatgccggtaaagaaaagttgccgaagatgagactgcccacg
cgctcagacatgatatgcggctatgcctgcctcaaagggactgccgccatgcggaacacc
aaacgaggttcctggtacatcgaggctcttgctcaagtgttttctgagcgggcttgtgat
atgcacgtggccgacatgctggttaaggtgaacgcacttatcaaggatcgggaaggttat
gctcctggcacagaattccaccggtgcaaggagatgtctgaatactgcagcactctgtgc
cgccacctctacctgttcccaggacaccctcccacatga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (48)   
   RefSeq(nuc) (4)   
   GenBank (22)   
   EMBL (22)   
3D Structure (15)   
   PDB (15)   
Protein domain (3)   
   Pfam (3)   
All databases (100)   

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