KEGG   Homo sapiens (human): 83933
Entry
83933             CDS       T01001                                 
Symbol
HDAC10, HD10
Name
(RefSeq) histone deacetylase 10
  KO
K18671  histone deacetylase 10 [EC:3.5.1.98]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04613  Neutrophil extracellular trap formation
hsa05034  Alcoholism
hsa05203  Viral carcinogenesis
Drug target
Abexinostat (DG01402): D10060 D10084
Belinostat: D08870<US>
Bocodepsin (DG03260): D12551 D12552
Entinostat: D09338
Fimepinostat: D11319
Givinostat (DG03284): D12742 D12743
Panobinostat (DG01403): D10019 D10319
Quisinostat (DG01407): D10321 D10322
Remetinostat: D10977
Romidepsin: D06637<JP/US>
Tucidinostat: D10993<JP>
Vorinostat: D06320<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    83933 (HDAC10)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    83933 (HDAC10)
  09165 Substance dependence
   05034 Alcoholism
    83933 (HDAC10)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    83933 (HDAC10)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.98  histone deacetylase
     83933 (HDAC10)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    Class II HDACs
     83933 (HDAC10)
SSDB
Motif
Pfam: Hist_deacetyl
Other DBs
NCBI-GeneID: 83933
NCBI-ProteinID: NP_114408
OMIM: 608544
HGNC: 18128
Ensembl: ENSG00000100429
UniProt: Q969S8
Position
22:complement(50245183..50251265)
AA seq 669 aa
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
NT seq 2010 nt   +upstreamnt  +downstreamnt
atggggaccgcgcttgtgtaccatgaggacatgacggccacccggctgctctgggacgac
cccgagtgcgagatcgagcgtcctgagcgcctgaccgcagccctggatcgcctgcggcag
cgcggcctggaacagaggtgtctgcggttgtcagcccgcgaggcctcggaagaggagctg
ggcctggtgcacagcccagagtatgtatccctggtcagggagacccaggtcctaggcaag
gaggagctgcaggcgctgtccggacagttcgacgccatctacttccacccgagtaccttt
cactgcgcgcggctggccgcaggggctggactgcagctggtggacgctgtgctcactgga
gctgtgcaaaatgggcttgccctggtgaggcctcccgggcaccatggccagagggcggct
gccaacgggttctgtgtgttcaacaacgtggccatagcagctgcacatgccaagcagaaa
cacgggctacacaggatcctcgtcgtggactgggatgtgcaccatggccaggggatccag
tatctctttgaggatgaccccagcgtcctttacttctcctggcaccgctatgagcatggg
cgcttctggcctttcctgcgagagtcagatgcagacgcagtggggcggggacagggcctc
ggcttcactgtcaacctgccctggaaccaggttgggatgggaaacgctgactacgtggct
gccttcctgcacctgctgctcccactggcctttgagtttgaccctgagctggtgctggtc
tcggcaggatttgactcagccatcggggaccctgaggggcaaatgcaggccacgccagag
tgcttcgcccacctcacacagctgctgcaggtgctggccggcggccgggtctgtgccgtg
ctggagggcggctaccacctggagtcactggcggagtcagtgtgcatgacagtacagacg
ctgctgggtgacccggccccacccctgtcagggccaatggcgccatgtcagagtgcccta
gagtccatccagagtgcccgtgctgcccaggccccgcactggaagagcctccagcagcaa
gatgtgaccgctgtgccgatgagccccagcagccactccccagaggggaggcctccacct
ctgctgcctgggggtccagtgtgtaaggcagctgcatctgcaccgagctccctcctggac
cagccgtgcctctgccccgcaccctctgtccgcaccgctgttgccctgacaacgccggat
atcacattggttctgccccctgacgtcatccaacaggaagcgtcagccctgagggaggag
acagaagcctgggccaggccacacgagtccctggcccgggaggaggccctcactgcactt
gggaagctcctgtacctcttagatgggatgctggatgggcaggtgaacagtggtatagca
gccactccagcctctgctgcagcagccaccctggatgtggctgttcggagaggcctgtcc
cacggagcccagaggctgctgtgcgtggccctgggacagctggaccggcctccagacctc
gcccatgacgggaggagtctgtggctgaacatcaggggcaaggaggcggctgccctatcc
atgttccatgtctccacgccactgccagtgatgaccggtggtttcctgagctgcatcttg
ggcttggtgctgcccctggcctatggcttccagcctgacctggtgctggtggcgctgggg
cctggccatggcctgcagggcccccacgctgcactcctggctgcaatgcttcgggggctg
gcagggggccgagtcctggccctcctggaggagaactccacaccccagctagcagggatc
ctggcccgggtgctgaatggagaggcacctcctagcctaggcccttcctctgtggcctcc
ccagaggacgtccaggccctgatgtacctgagagggcagctggagcctcagtggaagatg
ttgcagtgccatcctcacctggtggcttga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (17)   
   KEGG DRUG (17)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (32)   
   RefSeq(nuc) (2)   
   GenBank (15)   
   EMBL (15)   
Protein domain (1)   
   Pfam (1)   
All databases (89)   

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