KEGG   Homo sapiens (human): 8445
Entry
8445              CDS       T01001                                 
Symbol
DYRK2
Name
(RefSeq) dual specificity tyrosine phosphorylation regulated kinase 2
  KO
K18669  dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4 [EC:2.7.12.1]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8445 (DYRK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.1  dual-specificity kinase
     8445 (DYRK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  DYRK family [OT]
   8445 (DYRK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH ABC1 Kdo Choline_kinase Kinase-like RIO1 YrbL-PhoP_reg
Other DBs
NCBI-GeneID: 8445
NCBI-ProteinID: NP_006473
OMIM: 603496
HGNC: 3093
Ensembl: ENSG00000127334
UniProt: Q92630
Structure
Position
12:67648745..67665406
AA seq 601 aa
MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S
NT seq 1806 nt   +upstreamnt  +downstreamnt
atgttaaccaggaaaccttcggccgccgctcccgccgcctacccgaccggccgaggtggg
gacagcgccgttcgtcagcttcaggcttccccggggctcggtgcaggggccacccggagc
ggagtggggactggcccgccctcccccatcgccctgccgcctctccgggccagcaacgct
gccgccgcagcccacacgattggcggcagtaagcacacaatgaatgatcacctgcatgtc
ggcagccacgctcacggacagatccaggttcaacagttgtttgaggataacagtaacaag
cggacagtgctcacgacacaaccaaatgggcttacaacagtgggcaaaacgggcttgcca
gtggtgccagagcggcagctggacagcattcatagacggcaggggagctccacctctcta
aagtccatggaaggcatggggaaggtgaaagccacccccatgacacctgaacaagcaatg
aagcaatacatgcaaaaactcacagccttcgaacaccatgagattttcagctaccctgaa
atatatttcttgggtctaaatgctaagaagcgccagggcatgacaggtgggcccaacaat
ggtggctatgatgatgaccagggatcatatgtgcaggtgccccacgatcacgtggcttac
aggtatgaggtcctcaaggtcattgggaaggggagctttgggcaggtggtcaaggcctac
gatcacaaagtccaccagcacgtggccctaaagatggtgcggaatgagaagcgcttccac
cggcaagcagcggaggagatccgaatcctggaacacctgcggaagcaggacaaggataac
acaatgaatgtcatccatatgctggagaatttcaccttccgcaaccacatctgcatgacg
tttgagctgctgagcatgaacctctatgagctcatcaagaagaataaattccagggcttc
agtctgcctttggttcgcaagtttgcccactcgattctgcagtgcttggatgctttgcac
aaaaacagaataattcactgtgaccttaagcccgagaacattttgttaaagcagcagggt
agaagcggtattaaagtaattgattttggctccagttgttacgagcatcagcgtgtctac
acgtacatccagtcgcgtttttaccgggctccagaagtgatccttggggccaggtatggc
atgcccattgatatgtggagcctgggctgcattttagcagagctcctgacgggttacccc
ctcttgcctggggaagatgaaggggaccagctggcctgtatgattgaactgttgggcatg
ccctcacagaaactgctggatgcatccaaacgagccaaaaattttgtgagctccaagggt
tatccccgttactgcactgtcacgactctctcagatggctctgtggtcctaaacggaggc
cgttcccggagggggaaactgaggggcccaccggagagcagagagtgggggaacgcgctg
aaggggtgtgatgatccccttttccttgacttcttaaaacagtgtttagagtgggatcct
gcagtgcgcatgaccccaggccaggctttgcggcacccctggctgaggaggcggttgcca
aagcctcccaccggggagaaaacgtcagtgaaaaggataactgagagcaccggtgctatc
acatctatatccaagttacctccaccttctagctcagcttccaaactgaggactaatttg
gcgcagatgacagatgccaatgggaatattcagcagaggacagtgttgccaaaacttgtt
agctga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
3D Structure (22)   
   PDB (22)   
Protein domain (9)   
   Pfam (9)   
All databases (86)   

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